diff --git a/goldens/material/chips/index.api.md b/goldens/material/chips/index.api.md
index 9ced63b6784d..0cc3258191bf 100644
--- a/goldens/material/chips/index.api.md
+++ b/goldens/material/chips/index.api.md
@@ -19,6 +19,7 @@ import * as i0 from '@angular/core';
 import * as i2 from '@angular/cdk/bidi';
 import { InjectionToken } from '@angular/core';
 import { Injector } from '@angular/core';
+import { ModifierKey } from '@angular/cdk/keycodes';
 import { NgControl } from '@angular/forms';
 import { NgForm } from '@angular/forms';
 import { NgZone } from '@angular/core';
@@ -304,7 +305,7 @@ export class MatChipInput implements MatChipTextControl, OnChanges, OnDestroy {
     _onInput(): void;
     placeholder: string;
     readonly: boolean;
-    separatorKeyCodes: readonly number[] | ReadonlySet<number>;
+    separatorKeyCodes: readonly (number | SeparatorKey)[] | ReadonlySet<number | SeparatorKey>;
     // (undocumented)
     setDescribedByIds(ids: string[]): void;
     // (undocumented)
@@ -472,7 +473,7 @@ export class MatChipRow extends MatChip implements AfterViewInit {
 export interface MatChipsDefaultOptions {
     hideSingleSelectionIndicator?: boolean;
     inputDisabledInteractive?: boolean;
-    separatorKeyCodes: readonly number[] | ReadonlySet<number>;
+    separatorKeyCodes: readonly (number | SeparatorKey)[] | ReadonlySet<number | SeparatorKey>;
 }
 
 // @public
@@ -564,6 +565,14 @@ export class MatChipTrailingIcon extends MatChipContent {
     static ɵfac: i0.ɵɵFactoryDeclaration<MatChipTrailingIcon, never>;
 }
 
+// @public
+export interface SeparatorKey {
+    // (undocumented)
+    keyCode: number;
+    // (undocumented)
+    modifiers: readonly ModifierKey[];
+}
+
 // (No @packageDocumentation comment for this package)
 
 ```
diff --git a/src/material/chips/chip-input.spec.ts b/src/material/chips/chip-input.spec.ts
index 7bc043c2e321..a4d8abe30568 100644
--- a/src/material/chips/chip-input.spec.ts
+++ b/src/material/chips/chip-input.spec.ts
@@ -303,6 +303,40 @@ describe('MatChipInput', () => {
 
       expect(testChipInput.add).not.toHaveBeenCalled();
     });
+
+    it('should ignore modifier keys when `SeparatorKey.modifiers` is empty', () => {
+      spyOn(testChipInput, 'add');
+
+      chipInputDirective.separatorKeyCodes = [{keyCode: COMMA, modifiers: []}];
+      fixture.detectChanges();
+
+      // With a modifier.
+      dispatchKeyboardEvent(inputNativeElement, 'keydown', COMMA, undefined, {shift: true});
+      expect(testChipInput.add).not.toHaveBeenCalled();
+
+      // Without a modifier.
+      dispatchKeyboardEvent(inputNativeElement, 'keydown', COMMA);
+      expect(testChipInput.add).toHaveBeenCalledTimes(1);
+    });
+
+    it('should only allow modifiers from the `SeparatorKey.modifiers` array', () => {
+      spyOn(testChipInput, 'add');
+
+      chipInputDirective.separatorKeyCodes = [{keyCode: COMMA, modifiers: ['ctrlKey']}];
+      fixture.detectChanges();
+
+      // Without a modifier.
+      dispatchKeyboardEvent(inputNativeElement, 'keydown', COMMA);
+      expect(testChipInput.add).not.toHaveBeenCalled();
+
+      // With a different modifier.
+      dispatchKeyboardEvent(inputNativeElement, 'keydown', COMMA, undefined, {shift: true});
+      expect(testChipInput.add).not.toHaveBeenCalled();
+
+      // With the correct modifier.
+      dispatchKeyboardEvent(inputNativeElement, 'keydown', COMMA, undefined, {control: true});
+      expect(testChipInput.add).toHaveBeenCalledTimes(1);
+    });
   });
 });
 
diff --git a/src/material/chips/chip-input.ts b/src/material/chips/chip-input.ts
index db6134d4d9fc..b7305e7fb88f 100644
--- a/src/material/chips/chip-input.ts
+++ b/src/material/chips/chip-input.ts
@@ -6,7 +6,7 @@
  * found in the LICENSE file at https://angular.dev/license
  */
 
-import {BACKSPACE, hasModifierKey} from '@angular/cdk/keycodes';
+import {BACKSPACE, hasModifierKey, ModifierKey} from '@angular/cdk/keycodes';
 import {
   Directive,
   ElementRef,
@@ -20,7 +20,7 @@ import {
 } from '@angular/core';
 import {_IdGenerator} from '@angular/cdk/a11y';
 import {MatFormField, MAT_FORM_FIELD} from '../form-field';
-import {MatChipsDefaultOptions, MAT_CHIPS_DEFAULT_OPTIONS} from './tokens';
+import {MatChipsDefaultOptions, MAT_CHIPS_DEFAULT_OPTIONS, SeparatorKey} from './tokens';
 import {MatChipGrid} from './chip-grid';
 import {MatChipTextControl} from './chip-text-control';
 
@@ -97,7 +97,7 @@ export class MatChipInput implements MatChipTextControl, OnChanges, OnDestroy {
    * Defaults to `[ENTER]`.
    */
   @Input('matChipInputSeparatorKeyCodes')
-  separatorKeyCodes: readonly number[] | ReadonlySet<number>;
+  separatorKeyCodes: readonly (number | SeparatorKey)[] | ReadonlySet<number | SeparatorKey>;
 
   /** Emitted when a chip is to be added. */
   @Output('matChipInputTokenEnd')
@@ -242,8 +242,33 @@ export class MatChipInput implements MatChipTextControl, OnChanges, OnDestroy {
   }
 
   /** Checks whether a keycode is one of the configured separators. */
-  private _isSeparatorKey(event: KeyboardEvent) {
-    return !hasModifierKey(event) && new Set(this.separatorKeyCodes).has(event.keyCode);
+  private _isSeparatorKey(event: KeyboardEvent): boolean {
+    if (!this.separatorKeyCodes) {
+      return false;
+    }
+
+    for (const key of this.separatorKeyCodes) {
+      let keyCode: number;
+      let modifiers: readonly ModifierKey[] | null;
+
+      if (typeof key === 'number') {
+        keyCode = key;
+        modifiers = null;
+      } else {
+        keyCode = key.keyCode;
+        modifiers = key.modifiers;
+      }
+
+      const modifiersMatch = !modifiers?.length
+        ? !hasModifierKey(event)
+        : hasModifierKey(event, ...modifiers);
+
+      if (keyCode === event.keyCode && modifiersMatch) {
+        return true;
+      }
+    }
+
+    return false;
   }
 
   /** Gets the value to set on the `readonly` attribute. */
diff --git a/src/material/chips/tokens.ts b/src/material/chips/tokens.ts
index a95ed2c0b132..431a1a7ed17f 100644
--- a/src/material/chips/tokens.ts
+++ b/src/material/chips/tokens.ts
@@ -6,13 +6,19 @@
  * found in the LICENSE file at https://angular.dev/license
  */
 
-import {ENTER} from '@angular/cdk/keycodes';
+import {ENTER, ModifierKey} from '@angular/cdk/keycodes';
 import {InjectionToken} from '@angular/core';
 
+/** Key that can be used as a separator between chips. */
+export interface SeparatorKey {
+  keyCode: number;
+  modifiers: readonly ModifierKey[];
+}
+
 /** Default options, for the chips module, that can be overridden. */
 export interface MatChipsDefaultOptions {
   /** The list of key codes that will trigger a chipEnd event. */
-  separatorKeyCodes: readonly number[] | ReadonlySet<number>;
+  separatorKeyCodes: readonly (number | SeparatorKey)[] | ReadonlySet<number | SeparatorKey>;
 
   /** Whether icon indicators should be hidden for single-selection. */
   hideSingleSelectionIndicator?: boolean;