diff --git a/sdks/python/gen_protos.py b/sdks/python/gen_protos.py
index a2cd1bd4cef3..d07f046fd229 100644
--- a/sdks/python/gen_protos.py
+++ b/sdks/python/gen_protos.py
@@ -21,6 +21,7 @@
 import argparse
 import contextlib
 import glob
+import importlib.resources
 import inspect
 import logging
 import os
@@ -31,8 +32,6 @@
 from collections import defaultdict
 from importlib import import_module
 
-import pkg_resources
-
 LOG = logging.getLogger()
 LOG.setLevel(logging.INFO)
 
@@ -474,7 +473,7 @@ def generate_proto_files(force=False):
 
   protoc_gen_mypy = _find_protoc_gen_mypy()
   from grpc_tools import protoc
-  builtin_protos = pkg_resources.resource_filename('grpc_tools', '_proto')
+  builtin_protos = importlib.resources.files('grpc_tools') / '_proto'
   args = (
       [sys.executable] +  # expecting to be called from command line
       ['--proto_path=%s' % builtin_protos] +
diff --git a/sdks/python/setup.py b/sdks/python/setup.py
index d6c4088c1be4..a98eaab33361 100644
--- a/sdks/python/setup.py
+++ b/sdks/python/setup.py
@@ -31,9 +31,7 @@
 
 # pylint: disable=ungrouped-imports
 import setuptools
-from pkg_resources import normalize_path
-from pkg_resources import parse_version
-from pkg_resources import to_filename
+from packaging.version import parse
 from setuptools import Command
 
 # pylint: disable=wrong-import-order
@@ -43,6 +41,14 @@
 from distutils.errors import DistutilsError  # isort:skip
 
 
+def to_filename(name: str) -> str:
+  return name.replace('-', '_')
+
+
+def normalize_path(filename):
+  return os.path.normcase(os.path.realpath(os.path.normpath(filename)))
+
+
 class mypy(Command):
   user_options = []
 
@@ -101,7 +107,7 @@ def get_version():
 RECOMMENDED_MIN_PIP_VERSION = '19.3.0'
 try:
   _PIP_VERSION = distribution('pip').version
-  if parse_version(_PIP_VERSION) < parse_version(RECOMMENDED_MIN_PIP_VERSION):
+  if parse(_PIP_VERSION) < parse(RECOMMENDED_MIN_PIP_VERSION):
     warnings.warn(
         "You are using version {0} of pip. " \
         "However, the recommended min version is {1}.".format(
@@ -116,7 +122,7 @@ def get_version():
 REQUIRED_CYTHON_VERSION = '3.0.0'
 try:
   _CYTHON_VERSION = distribution('cython').version
-  if parse_version(_CYTHON_VERSION) < parse_version(REQUIRED_CYTHON_VERSION):
+  if parse(_CYTHON_VERSION) < parse(REQUIRED_CYTHON_VERSION):
     warnings.warn(
         "You are using version {0} of cython. " \
         "However, version {1} is recommended.".format(
@@ -355,7 +361,7 @@ def get_portability_package_data():
           'fasteners>=0.3,<1.0',
           # TODO(https://github.com/grpc/grpc/issues/37710): Unpin grpc
           'grpcio>=1.33.1,<2,!=1.48.0,!=1.59.*,!=1.60.*,!=1.61.*,!=1.62.0,!=1.62.1,<1.66.0; python_version <= "3.12"',  # pylint: disable=line-too-long
-          'grpcio>=1.67.0; python_version >= "3.13"', 
+          'grpcio>=1.67.0; python_version >= "3.13"',
           'hdfs>=2.1.0,<3.0.0',
           'httplib2>=0.8,<0.23.0',
           'jsonschema>=4.0.0,<5.0.0',