diff --git a/llvm/CMakeLists.txt b/llvm/CMakeLists.txt
index 672400ba2066..488148d843e2 100644
--- a/llvm/CMakeLists.txt
+++ b/llvm/CMakeLists.txt
@@ -1169,13 +1169,16 @@ if(NOT DEFINED ARM_TOOLCHAIN_ID)
 endif()
 # End downstream change: #124
 
-# Configure the three LLVM configuration header files.
+# Configure the LLVM configuration header files.
 configure_file(
   ${LLVM_MAIN_INCLUDE_DIR}/llvm/Config/config.h.cmake
   ${LLVM_INCLUDE_DIR}/llvm/Config/config.h)
 configure_file(
   ${LLVM_MAIN_INCLUDE_DIR}/llvm/Config/llvm-config.h.cmake
   ${LLVM_INCLUDE_DIR}/llvm/Config/llvm-config.h)
+configure_file(
+  ${LLVM_MAIN_INCLUDE_DIR}/llvm/Config/Targets.h.cmake
+  ${LLVM_INCLUDE_DIR}/llvm/Config/Targets.h)
 configure_file(
   ${LLVM_MAIN_INCLUDE_DIR}/llvm/Config/abi-breaking.h.cmake
   ${LLVM_INCLUDE_DIR}/llvm/Config/abi-breaking.h)
diff --git a/llvm/include/llvm/Config/Targets.h.cmake b/llvm/include/llvm/Config/Targets.h.cmake
new file mode 100644
index 000000000000..5bab635edc54
--- /dev/null
+++ b/llvm/include/llvm/Config/Targets.h.cmake
@@ -0,0 +1,90 @@
+/*===------- llvm/Config/Targets.h - LLVM target checks -----------*- C -*-===*/
+/*                                                                            */
+/* Part of the LLVM Project, under the Apache License v2.0 with LLVM          */
+/* Exceptions.                                                                */
+/* See https://llvm.org/LICENSE.txt for license information.                  */
+/* SPDX-License-Identifier: Apache-2.0 WITH LLVM-exception                    */
+/*                                                                            */
+/*===----------------------------------------------------------------------===*/
+
+/* This file enables clients to know whether specific targets are enabled. */
+
+#ifndef LLVM_CONFIG_TARGETS_H
+#define LLVM_CONFIG_TARGETS_H
+
+/* Define if the AArch64 target is built in */
+#cmakedefine01 LLVM_HAS_AARCH64_TARGET
+
+/* Define if the AMDGPU target is built in */
+#cmakedefine01 LLVM_HAS_AMDGPU_TARGET
+
+/* Define if the ARC target is built in */
+#cmakedefine01 LLVM_HAS_ARC_TARGET
+
+/* Define if the ARM target is built in */
+#cmakedefine01 LLVM_HAS_ARM_TARGET
+
+/* Define if the AVR target is built in */
+#cmakedefine01 LLVM_HAS_AVR_TARGET
+
+/* Define if the BPF target is built in */
+#cmakedefine01 LLVM_HAS_BPF_TARGET
+
+/* Define if the CSKY target is built in */
+#cmakedefine01 LLVM_HAS_CSKY_TARGET
+
+/* Define if the DirectX target is built in */
+#cmakedefine01 LLVM_HAS_DIRECTX_TARGET
+
+/* Define if the Hexagon target is built in */
+#cmakedefine01 LLVM_HAS_HEXAGON_TARGET
+
+/* Define if the Lanai target is built in */
+#cmakedefine01 LLVM_HAS_LANAI_TARGET
+
+/* Define if the LoongArch target is built in */
+#cmakedefine01 LLVM_HAS_LOONGARCH_TARGET
+
+/* Define if the M68k target is built in */
+#cmakedefine01 LLVM_HAS_M68K_TARGET
+
+/* Define if the Mips target is built in */
+#cmakedefine01 LLVM_HAS_MIPS_TARGET
+
+/* Define if the MSP430 target is built in */
+#cmakedefine01 LLVM_HAS_MSP430_TARGET
+
+/* Define if the NVPTX target is built in */
+#cmakedefine01 LLVM_HAS_NVPTX_TARGET
+
+/* Define if the PowerPC target is built in */
+#cmakedefine01 LLVM_HAS_POWERPC_TARGET
+
+/* Define if the RISCV target is built in */
+#cmakedefine01 LLVM_HAS_RISCV_TARGET
+
+/* Define if the Sparc target is built in */
+#cmakedefine01 LLVM_HAS_SPARC_TARGET
+
+/* Define if the SPIRV target is built in */
+#cmakedefine01 LLVM_HAS_SPIRV_TARGET
+
+/* Define if the SystemZ target is built in */
+#cmakedefine01 LLVM_HAS_SYSTEMZ_TARGET
+
+/* Define if the VE target is built in */
+#cmakedefine01 LLVM_HAS_VE_TARGET
+
+/* Define if the WebAssembly target is built in */
+#cmakedefine01 LLVM_HAS_WEBASSEMBLY_TARGET
+
+/* Define if the X86 target is built in */
+#cmakedefine01 LLVM_HAS_X86_TARGET
+
+/* Define if the XCore target is built in */
+#cmakedefine01 LLVM_HAS_XCORE_TARGET
+
+/* Define if the Xtensa target is built in */
+#cmakedefine01 LLVM_HAS_XTENSA_TARGET
+
+#endif
diff --git a/llvm/include/llvm/Config/llvm-config.h.cmake b/llvm/include/llvm/Config/llvm-config.h.cmake
index 4230eb850fa4..97f996338bc0 100644
--- a/llvm/include/llvm/Config/llvm-config.h.cmake
+++ b/llvm/include/llvm/Config/llvm-config.h.cmake
@@ -54,81 +54,6 @@
 /* LLVM name for the native target MCA init function, if available */
 #cmakedefine LLVM_NATIVE_TARGETMCA LLVMInitialize${LLVM_NATIVE_ARCH}TargetMCA
 
-/* Define if the AArch64 target is built in */
-#cmakedefine01 LLVM_HAS_AARCH64_TARGET
-
-/* Define if the AMDGPU target is built in */
-#cmakedefine01 LLVM_HAS_AMDGPU_TARGET
-
-/* Define if the ARC target is built in */
-#cmakedefine01 LLVM_HAS_ARC_TARGET
-
-/* Define if the ARM target is built in */
-#cmakedefine01 LLVM_HAS_ARM_TARGET
-
-/* Define if the AVR target is built in */
-#cmakedefine01 LLVM_HAS_AVR_TARGET
-
-/* Define if the BPF target is built in */
-#cmakedefine01 LLVM_HAS_BPF_TARGET
-
-/* Define if the CSKY target is built in */
-#cmakedefine01 LLVM_HAS_CSKY_TARGET
-
-/* Define if the DirectX target is built in */
-#cmakedefine01 LLVM_HAS_DIRECTX_TARGET
-
-/* Define if the Hexagon target is built in */
-#cmakedefine01 LLVM_HAS_HEXAGON_TARGET
-
-/* Define if the Lanai target is built in */
-#cmakedefine01 LLVM_HAS_LANAI_TARGET
-
-/* Define if the LoongArch target is built in */
-#cmakedefine01 LLVM_HAS_LOONGARCH_TARGET
-
-/* Define if the M68k target is built in */
-#cmakedefine01 LLVM_HAS_M68K_TARGET
-
-/* Define if the Mips target is built in */
-#cmakedefine01 LLVM_HAS_MIPS_TARGET
-
-/* Define if the MSP430 target is built in */
-#cmakedefine01 LLVM_HAS_MSP430_TARGET
-
-/* Define if the NVPTX target is built in */
-#cmakedefine01 LLVM_HAS_NVPTX_TARGET
-
-/* Define if the PowerPC target is built in */
-#cmakedefine01 LLVM_HAS_POWERPC_TARGET
-
-/* Define if the RISCV target is built in */
-#cmakedefine01 LLVM_HAS_RISCV_TARGET
-
-/* Define if the Sparc target is built in */
-#cmakedefine01 LLVM_HAS_SPARC_TARGET
-
-/* Define if the SPIRV target is built in */
-#cmakedefine01 LLVM_HAS_SPIRV_TARGET
-
-/* Define if the SystemZ target is built in */
-#cmakedefine01 LLVM_HAS_SYSTEMZ_TARGET
-
-/* Define if the VE target is built in */
-#cmakedefine01 LLVM_HAS_VE_TARGET
-
-/* Define if the WebAssembly target is built in */
-#cmakedefine01 LLVM_HAS_WEBASSEMBLY_TARGET
-
-/* Define if the X86 target is built in */
-#cmakedefine01 LLVM_HAS_X86_TARGET
-
-/* Define if the XCore target is built in */
-#cmakedefine01 LLVM_HAS_XCORE_TARGET
-
-/* Define if the Xtensa target is built in */
-#cmakedefine01 LLVM_HAS_XTENSA_TARGET
-
 /* Define if this is Unixish platform */
 #cmakedefine LLVM_ON_UNIX ${LLVM_ON_UNIX}
 
diff --git a/llvm/utils/gn/secondary/llvm/include/llvm/Config/BUILD.gn b/llvm/utils/gn/secondary/llvm/include/llvm/Config/BUILD.gn
index 4a7cbe4af9e9..36ec4a2c6fae 100644
--- a/llvm/utils/gn/secondary/llvm/include/llvm/Config/BUILD.gn
+++ b/llvm/utils/gn/secondary/llvm/include/llvm/Config/BUILD.gn
@@ -74,7 +74,10 @@ write_cmake_config("abi-breaking") {
 }
 
 write_cmake_config("config") {
-  public_deps = [ ":llvm-config" ]
+  public_deps = [
+    ":Targets",
+    ":llvm-config",
+  ]
 
   input = "config.h.cmake"
   output = "$target_gen_dir/config.h"
@@ -384,6 +387,12 @@ write_cmake_config("llvm-config") {
   } else {
     values += [ "LLVM_FORCE_ENABLE_STATS=" ]
   }
+}
+
+write_cmake_config("Targets") {
+  input = "Targets.h.cmake"
+  output = "$target_gen_dir/Targets.h"
+  values = []
 
   if (llvm_build_AArch64) {
     values += [ "LLVM_HAS_AARCH64_TARGET=1" ]
diff --git a/mlir/lib/Target/LLVM/NVVM/Target.cpp b/mlir/lib/Target/LLVM/NVVM/Target.cpp
index f8420385cbec..914a34969661 100644
--- a/mlir/lib/Target/LLVM/NVVM/Target.cpp
+++ b/mlir/lib/Target/LLVM/NVVM/Target.cpp
@@ -27,7 +27,7 @@
 #include "mlir/Target/LLVMIR/Export.h"
 
 #include "llvm/ADT/ScopeExit.h"
-#include "llvm/Config/llvm-config.h"
+#include "llvm/Config/Targets.h"
 #include "llvm/Support/FileSystem.h"
 #include "llvm/Support/FileUtilities.h"
 #include "llvm/Support/FormatVariadic.h"
diff --git a/mlir/unittests/Target/LLVM/SerializeNVVMTarget.cpp b/mlir/unittests/Target/LLVM/SerializeNVVMTarget.cpp
index cae713a1ce1d..af0af89c7d07 100644
--- a/mlir/unittests/Target/LLVM/SerializeNVVMTarget.cpp
+++ b/mlir/unittests/Target/LLVM/SerializeNVVMTarget.cpp
@@ -19,7 +19,7 @@
 #include "mlir/Target/LLVMIR/Dialect/NVVM/NVVMToLLVMIRTranslation.h"
 
 #include "llvm/Bitcode/BitcodeWriter.h"
-#include "llvm/Config/llvm-config.h" // for LLVM_HAS_NVPTX_TARGET
+#include "llvm/Config/Targets.h" // for LLVM_HAS_NVPTX_TARGET
 #include "llvm/IRReader/IRReader.h"
 #include "llvm/Support/MemoryBufferRef.h"
 #include "llvm/Support/Process.h"