diff --git a/packages/event-handler/src/rest/BaseRouter.ts b/packages/event-handler/src/rest/BaseRouter.ts
index b3eb854166..209bdba9e2 100644
--- a/packages/event-handler/src/rest/BaseRouter.ts
+++ b/packages/event-handler/src/rest/BaseRouter.ts
@@ -6,6 +6,8 @@ import {
 import type { Context } from 'aws-lambda';
 import type { ResolveOptions } from '../types/index.js';
 import type {
+  ErrorConstructor,
+  ErrorHandler,
   HttpMethod,
   Path,
   RouteHandler,
@@ -13,13 +15,15 @@ import type {
   RouterOptions,
 } from '../types/rest.js';
 import { HttpVerbs } from './constants.js';
+import { ErrorHandlerRegistry } from './ErrorHandlerRegistry.js';
 import { Route } from './Route.js';
 import { RouteHandlerRegistry } from './RouteHandlerRegistry.js';
 
 abstract class BaseRouter {
   protected context: Record<string, unknown>;
 
-  protected routeRegistry: RouteHandlerRegistry;
+  protected readonly routeRegistry: RouteHandlerRegistry;
+  protected readonly errorHandlerRegistry: ErrorHandlerRegistry;
 
   /**
    * A logger instance to be used for logging debug, warning, and error messages.
@@ -32,7 +36,7 @@ abstract class BaseRouter {
    */
   protected readonly isDev: boolean = false;
 
-  public constructor(options?: RouterOptions) {
+  protected constructor(options?: RouterOptions) {
     this.context = {};
     const alcLogLevel = getStringFromEnv({
       key: 'AWS_LAMBDA_LOG_LEVEL',
@@ -44,9 +48,19 @@ abstract class BaseRouter {
       warn: console.warn,
     };
     this.routeRegistry = new RouteHandlerRegistry({ logger: this.logger });
+    this.errorHandlerRegistry = new ErrorHandlerRegistry({
+      logger: this.logger,
+    });
     this.isDev = isDevMode();
   }
 
+  public errorHandler<T extends Error>(
+    errorType: ErrorConstructor<T> | ErrorConstructor<T>[],
+    handler: ErrorHandler<T>
+  ): void {
+    this.errorHandlerRegistry.register(errorType, handler);
+  }
+
   public abstract resolve(
     event: unknown,
     context: Context,
diff --git a/packages/event-handler/src/rest/ErrorHandlerRegistry.ts b/packages/event-handler/src/rest/ErrorHandlerRegistry.ts
new file mode 100644
index 0000000000..2a68b72d53
--- /dev/null
+++ b/packages/event-handler/src/rest/ErrorHandlerRegistry.ts
@@ -0,0 +1,74 @@
+import type { GenericLogger } from '@aws-lambda-powertools/commons/types';
+import type {
+  ErrorConstructor,
+  ErrorHandler,
+  ErrorHandlerRegistryOptions,
+} from '../types/rest.js';
+
+export class ErrorHandlerRegistry {
+  readonly #handlers: Map<ErrorConstructor, ErrorHandler> = new Map();
+
+  readonly #logger: Pick<GenericLogger, 'debug' | 'warn' | 'error'>;
+
+  public constructor(options: ErrorHandlerRegistryOptions) {
+    this.#logger = options.logger;
+  }
+
+  /**
+   * Registers an error handler for one or more error types.
+   *
+   * The handler will be called when an error of the specified type(s) is thrown.
+   * If multiple error types are provided, the same handler will be registered
+   * for all of them.
+   *
+   * @param errorType - The error constructor(s) to register the handler for
+   * @param handler - The error handler function to call when the error occurs
+   */
+  public register<T extends Error>(
+    errorType: ErrorConstructor<T> | ErrorConstructor<T>[],
+    handler: ErrorHandler<T>
+  ): void {
+    const errorTypes = Array.isArray(errorType) ? errorType : [errorType];
+
+    for (const type of errorTypes) {
+      if (this.#handlers.has(type)) {
+        this.#logger.warn(
+          `Handler for ${type.name} already exists. The previous handler will be replaced.`
+        );
+      }
+      this.#handlers.set(type, handler as ErrorHandler);
+    }
+  }
+
+  /**
+   * Resolves an error handler for the given error instance.
+   *
+   * The resolution process follows this order:
+   * 1. Exact constructor match
+   * 2. instanceof checks for inheritance
+   * 3. Name-based matching (fallback for bundling issues)
+   *
+   * @param error - The error instance to find a handler for
+   * @returns The error handler function or null if no match found
+   */
+  public resolve(error: Error): ErrorHandler | null {
+    const exactHandler = this.#handlers.get(
+      error.constructor as ErrorConstructor
+    );
+    if (exactHandler != null) return exactHandler;
+
+    for (const [errorType, handler] of this.#handlers) {
+      if (error instanceof errorType) {
+        return handler;
+      }
+    }
+
+    for (const [errorType, handler] of this.#handlers) {
+      if (error.name === errorType.name) {
+        return handler;
+      }
+    }
+
+    return null;
+  }
+}
diff --git a/packages/event-handler/src/types/rest.ts b/packages/event-handler/src/types/rest.ts
index 702862dd62..ffe71f3c89 100644
--- a/packages/event-handler/src/types/rest.ts
+++ b/packages/event-handler/src/types/rest.ts
@@ -77,6 +77,15 @@ type RouteRegistryOptions = {
   logger: Pick<GenericLogger, 'debug' | 'warn' | 'error'>;
 };
 
+type ErrorHandlerRegistryOptions = {
+  /**
+   * A logger instance to be used for logging debug, warning, and error messages.
+   *
+   * When no logger is provided, we'll only log warnings and errors using the global `console` object.
+   */
+  logger: Pick<GenericLogger, 'debug' | 'warn' | 'error'>;
+};
+
 type ValidationResult = {
   isValid: boolean;
   issues: string[];
@@ -87,6 +96,7 @@ export type {
   DynamicRoute,
   ErrorResponse,
   ErrorConstructor,
+  ErrorHandlerRegistryOptions,
   ErrorHandler,
   HttpStatusCode,
   HttpMethod,
diff --git a/packages/event-handler/tests/unit/rest/BaseRouter.test.ts b/packages/event-handler/tests/unit/rest/BaseRouter.test.ts
index 582139a8b5..ed63c0249b 100644
--- a/packages/event-handler/tests/unit/rest/BaseRouter.test.ts
+++ b/packages/event-handler/tests/unit/rest/BaseRouter.test.ts
@@ -2,7 +2,8 @@ import context from '@aws-lambda-powertools/testing-utils/context';
 import type { Context } from 'aws-lambda';
 import { beforeEach, describe, expect, it, vi } from 'vitest';
 import { BaseRouter } from '../../../src/rest/BaseRouter.js';
-import { HttpVerbs } from '../../../src/rest/constants.js';
+import { HttpErrorCodes, HttpVerbs } from '../../../src/rest/constants.js';
+import { BadRequestError } from '../../../src/rest/errors.js';
 import type {
   HttpMethod,
   Path,
@@ -213,4 +214,28 @@ describe('Class: BaseRouter', () => {
       expect(actual).toEqual(expected);
     });
   });
+
+  it('handles errors through registered error handlers', async () => {
+    // Prepare
+    class TestRouterWithErrorAccess extends TestResolver {
+      get testErrorHandlerRegistry() {
+        return this.errorHandlerRegistry;
+      }
+    }
+
+    const app = new TestRouterWithErrorAccess();
+    const errorHandler = (error: BadRequestError) => ({
+      statusCode: HttpErrorCodes.BAD_REQUEST,
+      error: error.name,
+      message: `Handled: ${error.message}`,
+    });
+
+    app.errorHandler(BadRequestError, errorHandler);
+
+    // Act & Assess
+    const registeredHandler = app.testErrorHandlerRegistry.resolve(
+      new BadRequestError('test')
+    );
+    expect(registeredHandler).toBe(errorHandler);
+  });
 });
diff --git a/packages/event-handler/tests/unit/rest/ErrorHandlerRegistry.test.ts b/packages/event-handler/tests/unit/rest/ErrorHandlerRegistry.test.ts
new file mode 100644
index 0000000000..ba233886d3
--- /dev/null
+++ b/packages/event-handler/tests/unit/rest/ErrorHandlerRegistry.test.ts
@@ -0,0 +1,166 @@
+import { describe, expect, it } from 'vitest';
+import { HttpErrorCodes } from '../../../src/rest/constants.js';
+import { ErrorHandlerRegistry } from '../../../src/rest/ErrorHandlerRegistry.js';
+import type { HttpStatusCode } from '../../../src/types/rest.js';
+
+const createErrorHandler =
+  (statusCode: HttpStatusCode, message?: string) => (error: Error) => ({
+    statusCode,
+    error: error.name,
+    message: message ?? error.message,
+  });
+
+class CustomError extends Error {
+  constructor(message: string) {
+    super(message);
+    this.name = 'CustomError';
+  }
+}
+
+class AnotherError extends Error {
+  constructor(message: string) {
+    super(message);
+    this.name = 'AnotherError';
+  }
+}
+
+class InheritedError extends CustomError {
+  constructor(message: string) {
+    super(message);
+    this.name = 'InheritedError';
+  }
+}
+
+describe('Class: ErrorHandlerRegistry', () => {
+  it('logs a warning when registering a duplicate error handler', () => {
+    // Prepare
+    const registry = new ErrorHandlerRegistry({ logger: console });
+    const handler1 = createErrorHandler(HttpErrorCodes.BAD_REQUEST, 'first');
+    const handler2 = createErrorHandler(HttpErrorCodes.NOT_FOUND, 'second');
+
+    // Act
+    registry.register(CustomError, handler1);
+    registry.register(CustomError, handler2);
+
+    // Assess
+    expect(console.warn).toHaveBeenCalledWith(
+      'Handler for CustomError already exists. The previous handler will be replaced.'
+    );
+
+    const result = registry.resolve(new CustomError('test'));
+    expect(result).toBe(handler2);
+  });
+
+  it('registers handlers for multiple error types', () => {
+    // Prepare
+    const registry = new ErrorHandlerRegistry({ logger: console });
+    const handler = createErrorHandler(HttpErrorCodes.BAD_REQUEST);
+
+    // Act
+    registry.register([CustomError, AnotherError], handler);
+
+    // Assess
+    expect(registry.resolve(new CustomError('test'))).toBe(handler);
+    expect(registry.resolve(new AnotherError('test'))).toBe(handler);
+  });
+
+  it('resolves handlers using exact constructor match', () => {
+    // Prepare
+    const registry = new ErrorHandlerRegistry({ logger: console });
+    const customHandler = createErrorHandler(HttpErrorCodes.BAD_REQUEST);
+    const anotherHandler = createErrorHandler(
+      HttpErrorCodes.INTERNAL_SERVER_ERROR
+    );
+
+    // Act
+    registry.register(CustomError, customHandler);
+    registry.register(AnotherError, anotherHandler);
+
+    // Assess
+    expect(registry.resolve(new CustomError('test'))).toBe(customHandler);
+    expect(registry.resolve(new AnotherError('test'))).toBe(anotherHandler);
+  });
+
+  it('resolves handlers using instanceof for inheritance', () => {
+    // Prepare
+    const registry = new ErrorHandlerRegistry({ logger: console });
+    const baseHandler = createErrorHandler(HttpErrorCodes.BAD_REQUEST);
+
+    // Act
+    registry.register(CustomError, baseHandler);
+
+    // Assess
+    const inheritedError = new InheritedError('test');
+    expect(registry.resolve(inheritedError)).toBe(baseHandler);
+  });
+
+  it('resolves handlers using name-based matching', () => {
+    // Prepare
+    const registry = new ErrorHandlerRegistry({ logger: console });
+    const handler = createErrorHandler(HttpErrorCodes.BAD_REQUEST);
+
+    // Act
+    registry.register(CustomError, handler);
+
+    const errorWithSameName = new Error('test');
+    errorWithSameName.name = 'CustomError';
+
+    // Assess
+    expect(registry.resolve(errorWithSameName)).toBe(handler);
+  });
+
+  it('returns null when no handler is found', () => {
+    // Prepare
+    const registry = new ErrorHandlerRegistry({ logger: console });
+    const handler = createErrorHandler(HttpErrorCodes.BAD_REQUEST);
+
+    // Act
+    registry.register(CustomError, handler);
+
+    // Assess
+    expect(registry.resolve(new AnotherError('test'))).toBeNull();
+    expect(registry.resolve(new Error('test'))).toBeNull();
+  });
+
+  it('prioritizes exact constructor match over instanceof', () => {
+    // Prepare
+    const registry = new ErrorHandlerRegistry({ logger: console });
+    const baseHandler = createErrorHandler(HttpErrorCodes.BAD_REQUEST);
+    const specificHandler = createErrorHandler(
+      HttpErrorCodes.INTERNAL_SERVER_ERROR
+    );
+
+    // Act
+    registry.register(CustomError, baseHandler);
+    registry.register(InheritedError, specificHandler);
+
+    // Assess
+    expect(registry.resolve(new InheritedError('test'))).toBe(specificHandler);
+  });
+
+  it('prioritizes instanceof match over name-based matching', () => {
+    // Prepare
+    const registry = new ErrorHandlerRegistry({ logger: console });
+    const baseHandler = createErrorHandler(HttpErrorCodes.BAD_REQUEST);
+    const nameHandler = createErrorHandler(
+      HttpErrorCodes.INTERNAL_SERVER_ERROR
+    );
+
+    // Create a class with different name but register with name matching
+    class DifferentNameError extends Error {
+      constructor(message: string) {
+        super(message);
+        this.name = 'CustomError'; // Same name as CustomError
+      }
+    }
+
+    // Act
+    registry.register(CustomError, baseHandler);
+    registry.register(DifferentNameError, nameHandler);
+
+    const error = new DifferentNameError('test');
+
+    // Assess
+    expect(registry.resolve(error)).toBe(nameHandler);
+  });
+});