diff --git a/packages/core/src/shared/awsClientBuilderV3.ts b/packages/core/src/shared/awsClientBuilderV3.ts
index c51cc009e91..9526b7df344 100644
--- a/packages/core/src/shared/awsClientBuilderV3.ts
+++ b/packages/core/src/shared/awsClientBuilderV3.ts
@@ -120,10 +120,12 @@ export class AWSClientBuilderV3 {
 
     private keyAwsService<C extends AwsClient>(serviceOptions: AwsServiceOptions<C>): string {
         // Serializing certain objects in the args allows us to detect when nested objects change (ex. new retry strategy, endpoints)
+        const profileId = this.context.getCredentialProfileName()
         return [
             String(serviceOptions.serviceClient),
             JSON.stringify(serviceOptions.clientOptions),
             serviceOptions.region,
+            profileId,
             serviceOptions.userAgent ? '1' : '0',
             serviceOptions.settings ? JSON.stringify(serviceOptions.settings.get('endpoints', {})) : '',
         ].join(':')
diff --git a/packages/toolkit/.changes/next-release/Bug Fix-6318dec2-72a8-4464-ab84-e51913624f8c.json b/packages/toolkit/.changes/next-release/Bug Fix-6318dec2-72a8-4464-ab84-e51913624f8c.json
new file mode 100644
index 00000000000..d1afd281fb5
--- /dev/null
+++ b/packages/toolkit/.changes/next-release/Bug Fix-6318dec2-72a8-4464-ab84-e51913624f8c.json	
@@ -0,0 +1,4 @@
+{
+	"type": "Bug Fix",
+	"description": "S3 node in explorer is not refreshed on profile change"
+}