diff --git a/CHANGELOG.md b/CHANGELOG.md
index 6933087e3..c66a2ca7e 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -5,6 +5,9 @@ The format is based on [Keep a Changelog](https://keepachangelog.com/en/1.0.0/),
 and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0.html).
 
 ## [Unreleased]
+### Added
+ * Added support for a subset of qualified method syntax introduced in Clojure 1.12 (#1109)
+
 ### Fixed
  * Fix a bug where tags in data readers were resolved as Vars within syntax quotes, rather than using standard data readers rules (#1129)
  * Fix a bug where `keyword` and `symbol` functions did not treat string arguments as potentially namespaced (#1131)
diff --git a/docs/differencesfromclojure.rst b/docs/differencesfromclojure.rst
index e6696814b..b5a18a99d 100644
--- a/docs/differencesfromclojure.rst
+++ b/docs/differencesfromclojure.rst
@@ -182,6 +182,8 @@ Host interoperability features generally match those of Clojure.
 
 * :lpy:fn:`new` is a macro for Clojure compatibility, as the ``new`` keyword is not required for constructing new objects in Python.
 * `Python builtins <https://docs.python.org/3/library/functions.html>`_ are available under the special namespace ``python`` (as ``python/abs``, for instance) without requiring an import.
+* The qualified constructor form ``Classname/new`` introduced in Clojure 1.12 is not supported, because ``new`` is a valid Python method identifier unlike in Java.
+* Qualified methods may be referenced with or without a leading ``.`` character regardless of whether they are static, class, or instance methods.
 
 .. seealso::
 
diff --git a/docs/pyinterop.rst b/docs/pyinterop.rst
index faa01a512..280e53996 100644
--- a/docs/pyinterop.rst
+++ b/docs/pyinterop.rst
@@ -116,6 +116,20 @@ As a convenience, Basilisp offers a more compact syntax for method names known a
 
     (.strftime now "%Y-%m-%d")  ;;=> "2020-03-31"
 
+Basilisp also supports the "qualified method" syntax introduced in Clojure 1.12, albeit with fewer restrictions than the Clojure implementation.
+In particular, there is no distinction between instance and static (or class) methods in syntax -- instance methods need not be prefixed with a leading ``.`` nor is it an error to prefix a static or class method with a leading ``.``.
+Static and class methods typically do not take an instance of their class as the first argument, so the distinction should already be clear by usage.
+
+.. code-block:: clojure
+
+   ;; Python str instance method str.split()
+   (python.str/split "a b c")   ;;=> #py ["a" "b" "c"]
+   (python.str/.split "a b c")  ;;=> #py ["a" "b" "c"]
+
+   ;; Python int classmethod int.from_bytes()
+   (python.int/from_bytes #b"\x00\x10")   ;;=> 16
+   (python.int/.from_bytes #b"\x00\x10")  ;;=> 16
+
 In Python, objects often expose properties which can be read directly from the instance.
 To read properties from the instance, you can use the ``(.- object property)`` syntax.
 
diff --git a/src/basilisp/lang/compiler/analyzer.py b/src/basilisp/lang/compiler/analyzer.py
index 33413b8d2..1ff3a86fa 100644
--- a/src/basilisp/lang/compiler/analyzer.py
+++ b/src/basilisp/lang/compiler/analyzer.py
@@ -3468,13 +3468,15 @@ def _list_node(form: ISeq, ctx: AnalyzerContext) -> Node:
             return handle_special_form(form, ctx)
         elif s.name.startswith(".-"):
             return _host_prop_ast(form, ctx)
-        elif s.name.startswith(".") and s.name != _DOUBLE_DOT_MACRO_NAME:
+        elif (
+            s.name.startswith(".") and s.ns is None and s.name != _DOUBLE_DOT_MACRO_NAME
+        ):
             return _host_call_ast(form, ctx)
 
     return _invoke_ast(form, ctx)
 
 
-def _resolve_nested_symbol(ctx: AnalyzerContext, form: sym.Symbol) -> HostField:
+def __resolve_nested_symbol(ctx: AnalyzerContext, form: sym.Symbol) -> HostField:
     """Resolve an attribute by recursively accessing the parent object
     as if it were its own namespaced symbol."""
     assert form.ns is not None
@@ -3580,6 +3582,23 @@ def __resolve_namespaced_symbol(  # pylint: disable=too-many-branches  # noqa: M
     ctx: AnalyzerContext, form: sym.Symbol
 ) -> Union[Const, HostField, MaybeClass, MaybeHostForm, VarRef]:
     """Resolve a namespaced symbol into a Python name or Basilisp Var."""
+    # Support Clojure 1.12 qualified method names
+    #
+    # Does not discriminate between static/class and instance methods (the latter of
+    # which must include a leading `.` in Clojure). In Basilisp it was always possible
+    # to access object methods (static or otherwise) using the `Classname/field` form
+    # because Python objects are essentially just fancy dicts. It is possible to call
+    # Python methods by referencing the method directly on the class with the instance
+    # as an argument:
+    #
+    #     "a b c".split() == str.split("a b c")  # => ["a", "b", "c"]
+    #
+    # Basilisp supported this from the beginning:
+    #
+    #     (python.str/split "a b c")  ;;=> #py ["a" "b" "c"]
+    if form.name.startswith(".") and form.name != _DOUBLE_DOT_MACRO_NAME:
+        form = sym.symbol(form.name[1:], ns=form.ns, meta=form.meta)
+
     assert form.ns is not None
 
     current_ns = ctx.current_ns
@@ -3632,7 +3651,7 @@ def __resolve_namespaced_symbol(  # pylint: disable=too-many-branches  # noqa: M
 
     if "." in form.ns:
         try:
-            return _resolve_nested_symbol(ctx, form)
+            return __resolve_nested_symbol(ctx, form)
         except CompilerException:
             raise ctx.AnalyzerException(
                 f"unable to resolve symbol '{form}' in this context", form=form
diff --git a/src/basilisp/lang/reader.py b/src/basilisp/lang/reader.py
index 0cd457a8a..6a675d4d8 100644
--- a/src/basilisp/lang/reader.py
+++ b/src/basilisp/lang/reader.py
@@ -1054,8 +1054,6 @@ def _read_sym(ctx: ReaderContext, is_reader_macro_sym: bool = False) -> MaybeSym
                 "All '.' separated segments of a namespace "
                 "must contain at least one character."
             )
-    if name.startswith(".") and ns is not None:
-        raise ctx.syntax_error("Symbols starting with '.' may not have a namespace")
     if ns is None:
         if name == "nil":
             return None
@@ -1065,6 +1063,8 @@ def _read_sym(ctx: ReaderContext, is_reader_macro_sym: bool = False) -> MaybeSym
             return False
         elif name == "&":
             return _AMPERSAND
+        elif name.startswith("."):
+            return sym.symbol(name)
     if ctx.is_syntax_quoted and not name.endswith("#") and not is_reader_macro_sym:
         return ctx.resolve(sym.symbol(name, ns))
     return sym.symbol(name, ns=ns)
diff --git a/tests/basilisp/compiler_test.py b/tests/basilisp/compiler_test.py
index 3806acc46..751cf8fc3 100644
--- a/tests/basilisp/compiler_test.py
+++ b/tests/basilisp/compiler_test.py
@@ -3652,6 +3652,24 @@ def test_interop_call(self, lcompile: CompileFn):
         assert "example" == lcompile('(. "www.example.com" (strip "cmowz."))')
         assert "example" == lcompile('(. "www.example.com" strip "cmowz.")')
 
+    @pytest.mark.parametrize(
+        "code,v",
+        [
+            ('(python.str/split "a b c")', ["a", "b", "c"]),
+            ('(python.str/.split "a b c")', ["a", "b", "c"]),
+            (
+                '(python.int/from_bytes #b"\\x00\\x10" #?@(:lpy310- [** :byteorder "big"]))',
+                16,
+            ),
+            (
+                '(python.int/.from_bytes #b"\\x00\\x10" #?@(:lpy310- [** :byteorder "big"]))',
+                16,
+            ),
+        ],
+    )
+    def test_interop_qualified_method(self, lcompile: CompileFn, code: str, v):
+        assert v == lcompile(code)
+
     def test_interop_prop_field_is_symbol(self, lcompile: CompileFn):
         with pytest.raises(compiler.CompilerException):
             lcompile("(.- 'some.ns/sym :ns)")
@@ -6124,6 +6142,18 @@ def test_nested_bare_sym_will_not_resolve(self, lcompile: CompileFn):
         with pytest.raises(compiler.CompilerException):
             lcompile("basilisp.lang.map.MapEntry.of")
 
+    @pytest.mark.parametrize(
+        "code,v",
+        [
+            ("python.str/split", str.split),
+            ("python.str/.split", str.split),
+            ("python.int/from_bytes", int.from_bytes),
+            ("python.int/.from_bytes", int.from_bytes),
+        ],
+    )
+    def test_qualified_method_resolves(self, lcompile: CompileFn, code: str, v):
+        assert v == lcompile(code)
+
     @pytest.mark.parametrize(
         "code",
         [
diff --git a/tests/basilisp/reader_test.py b/tests/basilisp/reader_test.py
index 26f867931..8c53232ef 100644
--- a/tests/basilisp/reader_test.py
+++ b/tests/basilisp/reader_test.py
@@ -600,7 +600,7 @@ class TestKeyword:
             ("a:b", ":a:b"),
         ],
     )
-    def test_legal_bare_symbol(self, v: str, raw: str):
+    def test_legal_bare_keyword(self, v: str, raw: str):
         assert kw.keyword(v) == read_str_first(raw)
 
     @pytest.mark.parametrize(
@@ -613,13 +613,13 @@ def test_legal_bare_symbol(self, v: str, raw: str):
             ("a:b", "a:b", ":a:b/a:b"),
         ],
     )
-    def test_legal_ns_symbol(self, k: str, ns: str, raw: str):
+    def test_legal_ns_keyword(self, k: str, ns: str, raw: str):
         assert kw.keyword(k, ns=ns) == read_str_first(raw)
 
     @pytest.mark.parametrize(
         "v", ["://", ":ns//kw", ":some/ns/sym", ":ns/sym/", ":/kw"]
     )
-    def test_illegal_symbol(self, v: str):
+    def test_illegal_keyword(self, v: str):
         with pytest.raises(reader.SyntaxError):
             read_str_first(v)
 
@@ -679,6 +679,7 @@ def test_legal_bare_symbol(self, s: str):
             ("sym", "ns", "ns/sym"),
             ("sym", "qualified.ns", "qualified.ns/sym"),
             ("sym", "really.qualified.ns", "really.qualified.ns/sym"),
+            (".interop", "ns.second", "ns.second/.interop"),
             ("sy:m", "ns", "ns/sy:m"),
             ("sy:m", "n:s", "n:s/sy:m"),
         ],
@@ -696,7 +697,6 @@ def test_legal_ns_symbol(self, s: str, ns: str, raw: str):
             "/sym",
             ".second.ns/name",
             "ns..third/name",
-            "ns.second/.interop",
             # This will raise because the default pushback depth of the
             # reader.StreamReader instance used by the reader is 5, so
             # we are unable to pushback more - characters consumed by
@@ -1161,15 +1161,43 @@ def test_reader_var_macro_works_with_unquote(self):
             ),
         ) == read_str_first("`(#'~'a-symbol)"), "Reader var macro works with unquote"
 
-    def test_do_not_resolve_unnamespaced_ampersand(self):
-        assert llist.l(sym.symbol("quote"), sym.symbol("&")) == read_str_first(
-            "`&"
-        ), "do not resolve the not namespaced ampersand"
+    @pytest.mark.parametrize(
+        "code,v",
+        [
+            ("`&", llist.l(sym.symbol("quote"), sym.symbol("&"))),
+            ("`nil", None),
+            ("`true", True),
+            ("`false", False),
+            ("`.interop", llist.l(sym.symbol("quote"), sym.symbol(".interop"))),
+        ],
+    )
+    def test_do_not_resolve_unnamespaced_special_symbols(self, code: str, v):
+        assert v == read_str_first(code)
 
-    def test_resolve_namespaced_ampersand(self):
-        assert llist.l(
-            sym.symbol("quote"), sym.symbol("&", ns="test-ns")
-        ) == read_str_first("`test-ns/&"), "resolve fq namespaced ampersand"
+    @pytest.mark.parametrize(
+        "code,v",
+        [
+            ("`test-ns/&", llist.l(sym.symbol("quote"), sym.symbol("&", ns="test-ns"))),
+            (
+                "`test-ns/nil",
+                llist.l(sym.symbol("quote"), sym.symbol("nil", ns="test-ns")),
+            ),
+            (
+                "`test-ns/true",
+                llist.l(sym.symbol("quote"), sym.symbol("true", ns="test-ns")),
+            ),
+            (
+                "`test-ns/false",
+                llist.l(sym.symbol("quote"), sym.symbol("false", ns="test-ns")),
+            ),
+            (
+                "`test-ns/.interop",
+                llist.l(sym.symbol("quote"), sym.symbol(".interop", ns="test-ns")),
+            ),
+        ],
+    )
+    def test_resolve_namespaced_special_symbols(self, code: str, v):
+        assert v == read_str_first(code)
 
     @pytest.mark.parametrize(
         "code,v",