diff --git a/.gitignore b/.gitignore
new file mode 100644
index 0000000..bd21564
--- /dev/null
+++ b/.gitignore
@@ -0,0 +1,5 @@
+# pixi environments
+.pixi/*
+!.pixi/config.toml
+
+target/
diff --git a/Cargo.lock b/Cargo.lock
index 79386b5..37d10c0 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -327,26 +327,6 @@ version = "0.22.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "72b3254f16251a8381aa12e40e3c4d2f0199f8c6508fbecb9d91f575e0fbb8c6"
 
-[[package]]
-name = "bindgen"
-version = "0.69.5"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "271383c67ccabffb7381723dea0672a673f292304fcb45c01cc648c7a8d58088"
-dependencies = [
- "bitflags",
- "cexpr",
- "clang-sys",
- "itertools 0.12.1",
- "lazy_static",
- "lazycell",
- "proc-macro2",
- "quote",
- "regex",
- "rustc-hash 1.1.0",
- "shlex",
- "syn 2.0.111",
-]
-
 [[package]]
 name = "bio-types"
 version = "1.0.4"
@@ -475,15 +455,6 @@ dependencies = [
  "shlex",
 ]
 
-[[package]]
-name = "cexpr"
-version = "0.6.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "6fac387a98bb7c37292057cffc56d62ecb629900026402633ae9160df93a8766"
-dependencies = [
- "nom 7.1.3",
-]
-
 [[package]]
 name = "cfg-if"
 version = "1.0.4"
@@ -513,17 +484,6 @@ version = "0.3.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "b0fc239e0f6cb375d2402d48afb92f76f5404fd1df208a41930ec81eda078bea"
 
-[[package]]
-name = "clang-sys"
-version = "1.8.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "0b023947811758c97c59bf9d1c188fd619ad4718dcaa767947df1cadb14f39f4"
-dependencies = [
- "glob",
- "libc",
- "libloading",
-]
-
 [[package]]
 name = "clap"
 version = "4.5.53"
@@ -692,20 +652,20 @@ checksum = "ef8ae57c4978a2acd8b869ce6b9ca1dfe817bff704c220209fdef2c0b75a01b9"
 
 [[package]]
 name = "derive-new"
-version = "0.6.0"
+version = "0.5.9"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d150dea618e920167e5973d70ae6ece4385b7164e0d799fe7c122dd0a5d912ad"
+checksum = "3418329ca0ad70234b9735dc4ceed10af4df60eff9c8e7b06cb5e520d92c3535"
 dependencies = [
  "proc-macro2",
  "quote",
- "syn 2.0.111",
+ "syn 1.0.109",
 ]
 
 [[package]]
 name = "derive-new"
-version = "0.7.0"
+version = "0.6.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "2cdc8d50f426189eef89dac62fabfa0abb27d5cc008f25bf4156a0203325becc"
+checksum = "d150dea618e920167e5973d70ae6ece4385b7164e0d799fe7c122dd0a5d912ad"
 dependencies = [
  "proc-macro2",
  "quote",
@@ -913,9 +873,9 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "98e6430fd1aab1f2586f8ad0ef27151bee96d5adcda39b39054fc4ce9c72d08a"
 dependencies = [
  "circular",
- "itertools 0.14.0",
+ "itertools",
  "log",
- "nom 8.0.0",
+ "nom",
  "thiserror 2.0.17",
 ]
 
@@ -1018,7 +978,6 @@ version = "2.2.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "e38d7f1c121cd22aa214cb4dadd4277dc5447391eac518b899b29ba6356fbbb2"
 dependencies = [
- "bindgen",
  "bzip2-sys",
  "cc",
  "curl-sys",
@@ -1316,15 +1275,6 @@ version = "1.70.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "a6cb138bb79a146c1bd460005623e142ef0181e3d0219cb493e02f7d08a35695"
 
-[[package]]
-name = "itertools"
-version = "0.12.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ba291022dbbd398a455acf126c1e341954079855bc60dfdda641363bd6922569"
-dependencies = [
- "either",
-]
-
 [[package]]
 name = "itertools"
 version = "0.14.0"
@@ -1366,12 +1316,6 @@ version = "1.5.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "bbd2bcb4c963f2ddae06a2efc7e9f3591312473c50c6685e1f298068316e66fe"
 
-[[package]]
-name = "lazycell"
-version = "1.3.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "830d08ce1d1d941e6b30645f1a0eb5643013d835ce3779a5fc208261dbe10f55"
-
 [[package]]
 name = "lexical-core"
 version = "1.0.6"
@@ -1452,16 +1396,6 @@ dependencies = [
  "zip",
 ]
 
-[[package]]
-name = "libloading"
-version = "0.8.9"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d7c4b02199fee7c5d21a5ae7d8cfa79a6ef5bb2fc834d6e9058e89c825efdc55"
-dependencies = [
- "cfg-if",
- "windows-link",
-]
-
 [[package]]
 name = "libm"
 version = "0.2.15"
@@ -1567,12 +1501,6 @@ dependencies = [
  "autocfg",
 ]
 
-[[package]]
-name = "minimal-lexical"
-version = "0.2.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "68354c5c6bd36d73ff3feceb05efa59b6acb7626617f4962be322a825e61f79a"
-
 [[package]]
 name = "miniz_oxide"
 version = "0.8.9"
@@ -1620,16 +1548,6 @@ dependencies = [
  "rustc_version",
 ]
 
-[[package]]
-name = "nom"
-version = "7.1.3"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d273983c5a657a70a3e8f2a01329822f3b8c8172b73826411a55751e404a0a4a"
-dependencies = [
- "memchr",
- "minimal-lexical",
-]
-
 [[package]]
 name = "nom"
 version = "8.0.0"
@@ -1926,7 +1844,7 @@ dependencies = [
  "pin-project-lite",
  "quinn-proto",
  "quinn-udp",
- "rustc-hash 2.1.1",
+ "rustc-hash",
  "rustls",
  "socket2",
  "thiserror 2.0.17",
@@ -1946,7 +1864,7 @@ dependencies = [
  "lru-slab",
  "rand 0.9.2",
  "ring",
- "rustc-hash 2.1.1",
+ "rustc-hash",
  "rustls",
  "rustls-pki-types",
  "slab",
@@ -2218,23 +2136,22 @@ dependencies = [
 
 [[package]]
 name = "rust-htslib"
-version = "0.51.0"
+version = "0.44.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "354416dd2300ff9e7aff8ddc747c875d6c5086f83c2cb2599f3692421c2b77fd"
+checksum = "7c7eb0f29fce64a4e22578905efef3d72389058016023279a58b282eb5c0c467"
 dependencies = [
  "bio-types",
  "byteorder",
  "custom_derive",
- "derive-new 0.7.0",
+ "derive-new 0.5.9",
  "hts-sys",
  "ieee754",
  "lazy_static",
  "libc",
- "libz-sys",
  "linear-map",
  "newtype_derive",
  "regex",
- "thiserror 2.0.17",
+ "thiserror 1.0.69",
  "url",
 ]
 
@@ -2254,12 +2171,6 @@ dependencies = [
  "serde_json",
 ]
 
-[[package]]
-name = "rustc-hash"
-version = "1.1.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "08d43f7aa6b08d49f382cde6a7982047c3426db949b1424bc4b7ec9ae12c6ce2"
-
 [[package]]
 name = "rustc-hash"
 version = "2.1.1"
@@ -2623,7 +2534,7 @@ dependencies = [
 
 [[package]]
 name = "thebigbam_calc"
-version = "0.1.0"
+version = "1.0.0"
 dependencies = [
  "anyhow",
  "atty",
diff --git a/Cargo.toml b/Cargo.toml
index 7410345..52cb6e1 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -20,7 +20,7 @@ python = ["pyo3"]
 
 [dependencies]
 # BAM/SAM reading
-rust-htslib = "0.51"
+rust-htslib = { version = "0.44", features = ["static"] }
 
 # Parallelism
 rayon = "1.10"
diff --git a/README.md b/README.md
index 9dc8c7e..aaa5c4f 100644
--- a/README.md
+++ b/README.md
@@ -16,10 +16,48 @@ Built with **Rust** for fast BAM processing and **Python/Bokeh** for interactive
 
 # Quick Start
 
-You need Rust and Python installed. Install Rust following instructions at: https://rust-lang.org/tools/install/
+You need conda installed. If you don't have it yet, you can install Miniconda following instructions at: https://docs.conda.io/en/latest/miniconda.html
 
 Then in command-line:
 
+```bash
+conda env create -f thebigbam_env.yaml
+conda activate thebigbam
+pip install git+https://github.com/bhagavadgitadu22/theBIGbam
+```
+
+Be aware that it may take quite some time to compile the Rust code during installation.
+
+To reduce the installation size, you can at the end remove the rust cache:
+
+```bash
+cargo clean
+```
+
+### Errors
+
+To avoid potential compilation errors:
+
+- On Linux: Install development headers: `sudo apt-get install libbz2-dev liblzma-dev zlib1g-dev clang libclang-dev`
+- On macOS: `brew install xz bzip2 zlib`
+- On HPC clusters: you may need to load the LLVM module first: `module load llvm`
+
+If you cannot use any of these methods and still get errors related to `libclang` during installation such as :
+
+```bash
+thread 'main' (3889591) panicked at /home/gmichoud/.cargo/registry/src/index.crates.io-1949cf8c6b5b557f/bindgen-0.69.5/lib.rs:622:31:
+        Unable to find libclang: "couldn't find any valid shared libraries matching: ['libclang.so', 'libclang-*.so', 'libclang.so.*', 'libclang-*.so.*'], set the `LIBCLANG_PATH` environment variable to a path where one of these files can be found (invalid: [])"
+        
+```
+
+Please set the `LIBCLANG_PATH` environment variable to the path where your `libclang` library is located. For example:
+
+```bash
+export LIBCLANG_PATH=$(python -c "import os; print(os.environ['CONDA_PREFIX'] + '/lib')")
+```
+
+Then try installing again.
+
 ```bash
 pip install git+https://github.com/bhagavadgitadu22/theBIGbam
 ```
@@ -46,6 +84,12 @@ thebigbam calculate \
 thebigbam serve --db tests/HK97/test.db --port 5006
 ```
 
+If you're using wsl, you may need to install the package `wslu` to allow opening the browser from the wsl terminal:
+
+```bash
+sudo apt install wslu
+```
+
 Open browser to http://localhost:5006
 
 See [the installation guide](docs/INSTALL.md) for more detailed instructions.
@@ -249,4 +293,4 @@ Export any metric as a contig x sample TSV matrix:
 thebigbam export -d my_database.db --metric Coverage_mean -o coverage.tsv
 ```
 
-Run `thebigbam export -h` to see the full list of available metrics.
\ No newline at end of file
+Run `thebigbam export -h` to see the full list of available metrics.
diff --git a/docs/INSTALL.md b/docs/INSTALL.md
index ab1812b..5d94a21 100644
--- a/docs/INSTALL.md
+++ b/docs/INSTALL.md
@@ -81,7 +81,7 @@ This installs in "editable" mode - changes to Python code take effect immediatel
 **Using conda/mamba (easiest):**
 
 ```bash
-mamba env create -f thebigbam_env.yaml
+conda env create -f thebigbam_env.yaml
 conda activate thebigbam
 pip install .  # Re-install in conda environment
 ```
diff --git a/pyproject.toml b/pyproject.toml
index 73ef0f2..96796ac 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -9,7 +9,7 @@ description = "Compression and interactive exploration of large-scale sequencing
 readme = "README.md"
 authors = [{ name = "Martin Boutroux", email = "martinboutroux@outlook.fr" }]
 license = { text = "MIT" }
-requires-python = ">=3.9"
+requires-python = ">=3.9,<3.13"
 classifiers = [
     "Development Status :: 5 - Production/Stable",
     "Intended Audience :: Science/Research",
@@ -18,12 +18,6 @@ classifiers = [
     "Programming Language :: Python :: 3",
     "Programming Language :: Rust",
 ]
-
-[project.urls]
-Homepage = "https://github.com/bhagavadgitadu22/theBIGbam"
-Repository = "https://github.com/bhagavadgitadu22/theBIGbam"
-Issues = "https://github.com/bhagavadgitadu22/theBIGbam/issues"
-
 dependencies = [
     "bokeh>=3.0",
     "panel>=1.0",
@@ -33,6 +27,13 @@ dependencies = [
     "duckdb>=1.0",
 ]
 
+[project.urls]
+Homepage = "https://github.com/bhagavadgitadu22/theBIGbam"
+Repository = "https://github.com/bhagavadgitadu22/theBIGbam"
+Issues = "https://github.com/bhagavadgitadu22/theBIGbam/issues"
+
+
+
 [project.optional-dependencies]
 dev = [
     "pytest>=7.0",
diff --git a/thebigbam/plotting/start_bokeh_server.py b/thebigbam/plotting/start_bokeh_server.py
index 59484c0..0bab064 100644
--- a/thebigbam/plotting/start_bokeh_server.py
+++ b/thebigbam/plotting/start_bokeh_server.py
@@ -984,7 +984,7 @@ def make_data_download_callback():
     toggle_stylesheet = InlineStyleSheet(css=toggle_css_text)
 
     # Load logo as base64 to avoid static file serving issues
-    logo_path = os.path.join(static_path, "logo.png")
+    logo_path = os.path.join(static_path, "LOGO.png")
     with open(logo_path, "rb") as f:
         logo_b64 = base64.b64encode(f.read()).decode("utf-8")
 
diff --git a/thebigbam_env.yaml b/thebigbam_env.yaml
index c2fb405..1d82a22 100644
--- a/thebigbam_env.yaml
+++ b/thebigbam_env.yaml
@@ -6,3 +6,8 @@ dependencies:
   - samtools=1.23
   - bwa-mem2=2.3
   - minimap2=2.30
+  - rust>=1.72
+  - libclang
+  - python=3.12
+  - blast
+