Perhaps base it off a .witness field in the inputs... with which case:
vsize of a transaction equals to 3 times of the size with original serialization, plus the size with new serialization, divide the result by 4 and round up to the next integer. For example, if a transaction is 200 bytes with new serialization, and becomes 99 bytes with marker, flag, and witness removed, the vsize is (99 * 3 + 200) / 4 = 125 with round up.