As per #5:
Probably the largest unsolved problem in the ecosystem is asynchronous module loading / splitting files into multiple small files. factor-bundle allows extracting shared code between bundles. The bundles then rely on being loaded in the right order. partition-bundle is similar, but allows bundles to be loaded with a loadJS() function.
Input on the topic would be greatly appreciated!
cc/ @kristoferjoseph @brianleroux