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Added State of the field section to manuscript
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JOSS/paper.bib

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@misc{mintlesion
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author = {{Mint Medical GmbH}},
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title = {Implementing RANO 2.0 for Neuro-Oncology Clinical Trials in mint Lesion},
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year = {2025},
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month = {Nov},
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howpublished = {\url{https://mint-medical.com/news/implementing-rano-20-for-neuro-oncology-clinical-trials-in-mint-lesion}},
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note = {Accessed: 2026-01-11},
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}
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@misc{graylight_rano,
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author = {{Graylight Imaging Sp. z o.o.}},
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title = {Automated RANO solution for clinical trial},
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year = {2026},
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howpublished = {\url{https://cdn.graylight-imaging.com/project/automated-rano-solution-for-clinical-trial/}},
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note = {Accessed: 2026-01-11},
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}
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@article{fedorov20123d,
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title={3D Slicer as an image computing platform for the Quantitative Imaging Network},
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author={Fedorov, Andriy and Beichel, Reinhard and Kalpathy-Cramer, Jayashree and Finet, Julien and Fillion-Robin, Jean-Christophe and Pujol, Sonia and Bauer, Christian and Jennings, Dominique and Fennessy, Fiona and Sonka, Milan and others},

JOSS/paper.md

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While the current pipeline is designed for enhancing glioblastoma, it can easily be adapted to other types of brain tumours by training new segmentation models, for example, for
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non-enhancing low-grade glioma or meningioma.
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# State of the field
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Commercial imaging platforms such as mint Lesion [@mintlesion] support configurable RANO 2.0 criteria for clinical-trial reads,
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including automated tumor burden tracking. Additionally, an AI-based algorithm developed by
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Graylight Imaging [@graylight_rano] demonstrates automated tumour segmentation, bidimensional and volumetric assessment aligned
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with RANO principles. These efforts reflect a trend toward integrating advanced automated image analysis into standardized
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response assessment to support clinical research and trial endpoint evaluation. In this context, RANO2.0-assist represents
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a non-commercial tool with the aim to facilitate further development in research and commercial applications.
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To the best of our knowledge, RANO2.0-assist is currently the only fully automatic tool for classification based on
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RANO 2.0 criteria that allows for interactive correction of tumour measurements.
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# Overview of RANO2.0-assist
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The key components of the RANO2.0-assist pipeline are shown in \autoref{fig:pipeline}.
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