diff --git a/.changeset/tidy-baboons-rest.md b/.changeset/tidy-baboons-rest.md
new file mode 100644
index 000000000000..ffc19964f3a6
--- /dev/null
+++ b/.changeset/tidy-baboons-rest.md
@@ -0,0 +1,5 @@
+---
+"wrangler": minor
+---
+
+Rename Hyperdrive local connection string environment variable from `WRANGLER_HYPERDRIVE_LOCAL_CONNECTION_STRING_<BINDING_NAME>` to `CLOUDFLARE_HYPERDRIVE_LOCAL_CONNECTION_STRING_<BINDING_NAME>`. The old variable name is still supported but will now show a deprecation warning.
diff --git a/packages/wrangler/e2e/dev.test.ts b/packages/wrangler/e2e/dev.test.ts
index ccb96c795a91..40f192e74ad5 100644
--- a/packages/wrangler/e2e/dev.test.ts
+++ b/packages/wrangler/e2e/dev.test.ts
@@ -684,7 +684,7 @@ describe("hyperdrive dev tests", () => {
 		const worker = helper.runLongLived("wrangler dev", {
 			env: {
 				...process.env,
-				WRANGLER_HYPERDRIVE_LOCAL_CONNECTION_STRING_HYPERDRIVE: `postgresql://user:pass@127.0.0.1:${port}/some_db`,
+				CLOUDFLARE_HYPERDRIVE_LOCAL_CONNECTION_STRING_HYPERDRIVE: `postgresql://user:pass@127.0.0.1:${port}/some_db`,
 			},
 		});
 
diff --git a/packages/wrangler/src/dev.ts b/packages/wrangler/src/dev.ts
index 3268f08744f4..5e58d9544fde 100644
--- a/packages/wrangler/src/dev.ts
+++ b/packages/wrangler/src/dev.ts
@@ -911,10 +911,17 @@ export function getBindings(
 
 	// Hyperdrive bindings
 	const hyperdriveBindings = configParam.hyperdrive.map((hyperdrive) => {
-		const connectionStringFromEnv =
-			process.env[
-				`WRANGLER_HYPERDRIVE_LOCAL_CONNECTION_STRING_${hyperdrive.binding}`
-			];
+		const prefix = `CLOUDFLARE_HYPERDRIVE_LOCAL_CONNECTION_STRING_`;
+		const deprecatedPrefix = `WRANGLER_HYPERDRIVE_LOCAL_CONNECTION_STRING_`;
+
+		let varName = `${prefix}${hyperdrive.binding}`;
+		let connectionStringFromEnv = process.env[varName];
+
+		if (!connectionStringFromEnv) {
+			varName = `${deprecatedPrefix}${hyperdrive.binding}`;
+			connectionStringFromEnv = process.env[varName];
+		}
+
 		// only require a local connection string in the wrangler file or the env if not using dev --remote
 		if (
 			local &&
@@ -922,7 +929,7 @@ export function getBindings(
 			hyperdrive.localConnectionString === undefined
 		) {
 			throw new UserError(
-				`When developing locally, you should use a local Postgres connection string to emulate Hyperdrive functionality. Please setup Postgres locally and set the value of the 'WRANGLER_HYPERDRIVE_LOCAL_CONNECTION_STRING_${hyperdrive.binding}' variable or "${hyperdrive.binding}"'s "localConnectionString" to the Postgres connection string.`,
+				`When developing locally, you should use a local Postgres connection string to emulate Hyperdrive functionality. Please setup Postgres locally and set the value of the '${prefix}${hyperdrive.binding}' variable or "${hyperdrive.binding}"'s "localConnectionString" to the Postgres connection string.`,
 				{ telemetryMessage: "no local hyperdrive connection string" }
 			);
 		}
@@ -930,8 +937,13 @@ export function getBindings(
 		// If there is a non-empty connection string specified in the environment,
 		// use that as our local connection string configuration.
 		if (connectionStringFromEnv) {
+			if (varName.startsWith(deprecatedPrefix)) {
+				logger.once.warn(
+					`Using "${deprecatedPrefix}<BINDING_NAME>" environment variable. This is deprecated. Please use "${prefix}<BINDING_NAME>" instead.`
+				);
+			}
 			logger.log(
-				`Found a non-empty WRANGLER_HYPERDRIVE_LOCAL_CONNECTION_STRING variable for binding. Hyperdrive will connect to this database during local development.`
+				`Found a non-empty ${varName} variable for binding. Hyperdrive will connect to this database during local development.`
 			);
 			hyperdrive.localConnectionString = connectionStringFromEnv;
 		}
diff --git a/packages/wrangler/src/environment-variables/factory.ts b/packages/wrangler/src/environment-variables/factory.ts
index 45bdba0079b2..b298b88fb580 100644
--- a/packages/wrangler/src/environment-variables/factory.ts
+++ b/packages/wrangler/src/environment-variables/factory.ts
@@ -25,7 +25,7 @@ type VariableNames =
 	// ## Development & Local Testing
 
 	/** Local database connection strings for Hyperdrive development. The * should be replaced with the Hyperdrive binding name in the Worker. */
-	| `WRANGLER_HYPERDRIVE_LOCAL_CONNECTION_STRING_${string}`
+	| `CLOUDFLARE_HYPERDRIVE_LOCAL_CONNECTION_STRING_${string}`
 	/** Suppress Hyperdrive-related warnings during development. */
 	| "NO_HYPERDRIVE_WARNING"
 	/** Path to HTTPS private key file for running the local development server in HTTPS mode. Without this Wrangler will generate keys automatically. */