diff --git a/src/internal/focus-visible/__tests__/iframes.test.tsx b/src/internal/focus-visible/__tests__/iframes.test.tsx
new file mode 100644
index 0000000..038b945
--- /dev/null
+++ b/src/internal/focus-visible/__tests__/iframes.test.tsx
@@ -0,0 +1,136 @@
+// Copyright Amazon.com, Inc. or its affiliates. All Rights Reserved.
+// SPDX-License-Identifier: Apache-2.0
+
+import React, { useState, useRef } from 'react';
+import ReactDOM from 'react-dom';
+import { render, fireEvent } from '@testing-library/react';
+import { useFocusVisible } from '..';
+
+function Fixture() {
+  const ref = useRef<HTMLButtonElement | null>(null);
+  useFocusVisible(ref);
+  return <button ref={ref}>Test</button>;
+}
+
+function FramePortal({ children }: { children: React.ReactNode }) {
+  const [iframeElement, setIframeElement] = useState<HTMLIFrameElement | null>(null);
+
+  return (
+    <iframe ref={setIframeElement}>
+      {iframeElement?.contentDocument && ReactDOM.createPortal(children, iframeElement.contentDocument.body)}
+    </iframe>
+  );
+}
+
+test('should disable focus by default', () => {
+  render(
+    <FramePortal>
+      <Fixture />
+    </FramePortal>
+  );
+  const frame = window.frames[0]!;
+  expect(frame.document.body).not.toHaveAttribute('data-awsui-focus-visible');
+});
+
+test('should enable focus when keyboard interaction happened in the main document', () => {
+  render(
+    <>
+      {/* Component in the main document to make sure listeners are added here too */}
+      <Fixture />
+      <FramePortal>
+        <Fixture />
+      </FramePortal>
+    </>
+  );
+  const frame = window.frames[0]!;
+  fireEvent.keyDown(document.body);
+  expect(document.body).toHaveAttribute('data-awsui-focus-visible', 'true');
+  expect(frame.document.body).toHaveAttribute('data-awsui-focus-visible', 'true');
+});
+
+test('should enable focus when keyboard interaction happened in the frame document', () => {
+  render(
+    <>
+      {/* Component in the main document to make sure listeners are added here too */}
+      <Fixture />
+      <FramePortal>
+        <Fixture />
+      </FramePortal>
+    </>
+  );
+  const frame = window.frames[0]!;
+  fireEvent.keyDown(frame.document.body);
+  expect(document.body).toHaveAttribute('data-awsui-focus-visible', 'true');
+  expect(frame.document.body).toHaveAttribute('data-awsui-focus-visible', 'true');
+});
+
+test('should disable focus when mouse is used in the main document after keyboard', () => {
+  render(
+    <>
+      {/* Component in the main document to make sure listeners are added here too */}
+      <Fixture />
+      <FramePortal>
+        <Fixture />
+      </FramePortal>
+    </>
+  );
+  const frame = window.frames[0]!;
+  fireEvent.keyDown(document.body);
+  fireEvent.mouseDown(document.body);
+  expect(document.body).not.toHaveAttribute('data-awsui-focus-visible');
+  expect(frame.document.body).not.toHaveAttribute('data-awsui-focus-visible');
+});
+
+test('should disable focus when mouse is used in the frame document after keyboard', () => {
+  render(
+    <FramePortal>
+      <Fixture />
+    </FramePortal>
+  );
+  const frame = window.frames[0]!;
+  fireEvent.keyDown(frame.document.body);
+  fireEvent.mouseDown(frame.document.body);
+  expect(frame.document.body).not.toHaveAttribute('data-awsui-focus-visible');
+});
+
+test('should remove listeners only from frame when the frame is unmounted', () => {
+  const outerAddEventListenerSpy = jest.spyOn(document, 'addEventListener');
+  const { rerender } = render(
+    <>
+      <Fixture />
+      <FramePortal>
+        <span />
+      </FramePortal>
+    </>
+  );
+
+  const frame = window.frames[0]!;
+  const innerAddEventListenerSpy = jest.spyOn(frame.document, 'addEventListener');
+  rerender(
+    <>
+      <Fixture />
+      <FramePortal>
+        <Fixture />
+      </FramePortal>
+    </>
+  );
+
+  expect(outerAddEventListenerSpy).toHaveBeenCalledTimes(2);
+  const outerSignal = (outerAddEventListenerSpy.mock.calls[0][2] as AddEventListenerOptions).signal!;
+  expect(outerSignal.aborted).toBe(false);
+
+  expect(innerAddEventListenerSpy).toHaveBeenCalledTimes(2);
+  const innerSignal = (innerAddEventListenerSpy.mock.calls[0][2] as AddEventListenerOptions).signal!;
+  expect(innerSignal.aborted).toBe(false);
+
+  rerender(
+    <>
+      <Fixture />
+      <FramePortal>
+        <span />
+      </FramePortal>
+    </>
+  );
+  expect(innerSignal.aborted).toBe(true);
+  expect(outerSignal.aborted).toBe(false);
+});
diff --git a/src/internal/focus-visible/__tests__/index.test.tsx b/src/internal/focus-visible/__tests__/index.test.tsx
index ab18b90..2e3364f 100644
--- a/src/internal/focus-visible/__tests__/index.test.tsx
+++ b/src/internal/focus-visible/__tests__/index.test.tsx
@@ -59,20 +59,26 @@ test('should work with multiple components', () => {
 });
 
 test('should add listeners only once', () => {
-  jest.spyOn(document, 'addEventListener');
-  jest.spyOn(document, 'removeEventListener');
+  const addEventListenerSpy = jest.spyOn(document, 'addEventListener');
   const { rerender } = render(
     <>
       <Fixture />
       <Fixture />
     </>
   );
-  expect(document.addEventListener).toHaveBeenCalledTimes(2);
-  expect(document.removeEventListener).toHaveBeenCalledTimes(0);
+
+  expect(addEventListenerSpy).toHaveBeenCalledTimes(2);
+  const signal = (addEventListenerSpy.mock.calls[0][2] as AddEventListenerOptions).signal!;
+  expect(signal.aborted).toBe(false);
+
+  addEventListenerSpy.mockClear();
   rerender(<Fixture />);
-  expect(document.removeEventListener).toHaveBeenCalledTimes(0);
+  expect(addEventListenerSpy).toHaveBeenCalledTimes(0);
+  expect(signal.aborted).toBe(false);
+
   rerender(<span />);
-  expect(document.removeEventListener).toHaveBeenCalledTimes(2);
+  expect(addEventListenerSpy).toHaveBeenCalledTimes(0);
+  expect(signal.aborted).toBe(true);
 });
 
 test('should initialize late components with updated state', () => {
diff --git a/src/internal/focus-visible/index.ts b/src/internal/focus-visible/index.ts
index 073b2aa..173d393 100644
--- a/src/internal/focus-visible/index.ts
+++ b/src/internal/focus-visible/index.ts
@@ -1,19 +1,25 @@
 // Copyright Amazon.com, Inc. or its affiliates. All Rights Reserved.
 // SPDX-License-Identifier: Apache-2.0
 
-import { useEffect } from 'react';
+import React, { useEffect } from 'react';
 import { isModifierKey } from '../keycode';
 
+const frames = new Map<Document, { componentsCount: number; abortController: AbortController }>();
+
 function setIsKeyboard(active: boolean) {
   if (active) {
-    document.body.setAttribute('data-awsui-focus-visible', 'true');
+    for (const currentDocument of frames.keys()) {
+      currentDocument.body.setAttribute('data-awsui-focus-visible', 'true');
+    }
   } else {
-    document.body.removeAttribute('data-awsui-focus-visible');
+    for (const currentDocument of frames.keys()) {
+      currentDocument.body.removeAttribute('data-awsui-focus-visible');
+    }
   }
 }
 
 function handleMousedown() {
-  return setIsKeyboard(false);
+  setIsKeyboard(false);
 }
 
 function handleKeydown(event: KeyboardEvent) {
@@ -22,29 +28,32 @@ function handleKeydown(event: KeyboardEvent) {
   }
 }
 
-let componentsCount = 0;
-
-function addListeners() {
-  document.addEventListener('mousedown', handleMousedown);
-  document.addEventListener('keydown', handleKeydown);
+function addListeners(currentDocument: Document): AbortController {
+  const abortController = new AbortController();
+  currentDocument.addEventListener('mousedown', handleMousedown, { signal: abortController.signal });
+  currentDocument.addEventListener('keydown', handleKeydown, { signal: abortController.signal });
+  return abortController;
 }
 
-function removeListeners() {
-  document.removeEventListener('mousedown', handleMousedown);
-  document.removeEventListener('keydown', handleKeydown);
-}
-
-export function useFocusVisible() {
+export function useFocusVisible(componentRef?: React.RefObject<HTMLElement | null>) {
   useEffect(() => {
-    if (componentsCount === 0) {
-      addListeners();
+    const currentDocument = componentRef?.current?.ownerDocument ?? document;
+
+    let frame = frames.get(currentDocument);
+    if (frame) {
+      frame.componentsCount++;
+    } else {
+      const abortController = addListeners(currentDocument);
+      frame = { componentsCount: 1, abortController };
+      frames.set(currentDocument, frame);
     }
-    componentsCount++;
+
     return () => {
-      componentsCount--;
-      if (componentsCount === 0) {
-        removeListeners();
+      frame.componentsCount--;
+      if (frame.componentsCount === 0) {
+        frame.abortController.abort();
+        frames.delete(currentDocument);
       }
     };
-  }, []);
+  }, [componentRef]);
 }