diff --git a/packages/react-client/src/ReactFlightClient.js b/packages/react-client/src/ReactFlightClient.js
index 61a67bce9d803..b966645623bbb 100644
--- a/packages/react-client/src/ReactFlightClient.js
+++ b/packages/react-client/src/ReactFlightClient.js
@@ -1010,10 +1010,15 @@ export function reportGlobalError(
   if (__DEV__) {
     const debugChannel = response._debugChannel;
     if (debugChannel !== undefined) {
-      // If we don't have any more ways of reading data, we don't have to send any
-      // more neither. So we close the writable side.
+      // If we don't have any more ways of reading data, we don't have to send
+      // any more neither. So we close the writable side.
       closeDebugChannel(debugChannel);
       response._debugChannel = undefined;
+      // Make sure the debug channel is not closed a second time when the
+      // Response gets GC:ed.
+      if (debugChannelRegistry !== null) {
+        debugChannelRegistry.unregister(response);
+      }
     }
   }
 }
@@ -2434,7 +2439,7 @@ function ResponseInstance(
         // When a Response gets GC:ed because nobody is referring to any of the
         // objects that lazily load from the Response anymore, then we can close
         // the debug channel.
-        debugChannelRegistry.register(this, debugChannel);
+        debugChannelRegistry.register(this, debugChannel, this);
       }
     }
   }