diff --git a/packages/react-devtools-shared/src/__tests__/store-test.js b/packages/react-devtools-shared/src/__tests__/store-test.js
index 3b60d5ae093e4..88144b4aa1c13 100644
--- a/packages/react-devtools-shared/src/__tests__/store-test.js
+++ b/packages/react-devtools-shared/src/__tests__/store-test.js
@@ -3079,6 +3079,10 @@ describe('Store', () => {
         <Suspense name="head-fallback" rects={[{x:1,y:2,width:10,height:1}]}>
         <Suspense name="main" rects={[{x:1,y:2,width:4,height:1}]}>
     `);
+
+    await actAsync(() => render(null));
+
+    expect(store).toMatchInlineSnapshot(``);
   });
 
   it('should handle an empty root', async () => {
diff --git a/packages/react-devtools-shared/src/backend/fiber/renderer.js b/packages/react-devtools-shared/src/backend/fiber/renderer.js
index aee89e8ca2c54..eb86ffea713fa 100644
--- a/packages/react-devtools-shared/src/backend/fiber/renderer.js
+++ b/packages/react-devtools-shared/src/backend/fiber/renderer.js
@@ -3070,6 +3070,24 @@ export function attach(
     }
   }
 
+  function unmountSuspenseChildrenRecursively(
+    contentInstance: DevToolsInstance,
+    stashedSuspenseParent: null | SuspenseNode,
+    stashedSuspensePrevious: null | SuspenseNode,
+    stashedSuspenseRemaining: null | SuspenseNode,
+  ): void {
+    // First unmount only the Offscreen boundary. I.e. the main content.
+    unmountInstanceRecursively(contentInstance);
+
+    // Next, we'll pop back out of the SuspenseNode that we added above and now we'll
+    // unmount the fallback, unmounting anything in the context of the parent SuspenseNode.
+    // Since the fallback conceptually blocks the parent.
+    reconcilingParentSuspenseNode = stashedSuspenseParent;
+    previouslyReconciledSiblingSuspenseNode = stashedSuspensePrevious;
+    remainingReconcilingChildrenSuspenseNodes = stashedSuspenseRemaining;
+    unmountRemainingChildren();
+  }
+
   function isChildOf(
     parentInstance: DevToolsInstance,
     childInstance: DevToolsInstance,
@@ -4015,6 +4033,7 @@ export function attach(
       debug('unmountInstanceRecursively()', instance, reconcilingParent);
     }
 
+    let shouldPopSuspenseNode = false;
     const stashedParent = reconcilingParent;
     const stashedPrevious = previouslyReconciledSibling;
     const stashedRemaining = remainingReconcilingChildren;
@@ -4035,11 +4054,46 @@ export function attach(
       previouslyReconciledSiblingSuspenseNode = null;
       remainingReconcilingChildrenSuspenseNodes =
         instance.suspenseNode.firstChild;
+
+      shouldPopSuspenseNode = true;
     }
 
     try {
       // Unmount the remaining set.
-      unmountRemainingChildren();
+      if (
+        (instance.kind === FIBER_INSTANCE ||
+          instance.kind === FILTERED_FIBER_INSTANCE) &&
+        instance.data.tag === SuspenseComponent &&
+        OffscreenComponent !== -1
+      ) {
+        const fiber = instance.data;
+        const contentFiberInstance = remainingReconcilingChildren;
+        const hydrated = isFiberHydrated(fiber);
+        if (hydrated) {
+          if (contentFiberInstance === null) {
+            throw new Error(
+              'There should always be an Offscreen Fiber child in a hydrated Suspense boundary.',
+            );
+          }
+
+          unmountSuspenseChildrenRecursively(
+            contentFiberInstance,
+            stashedSuspenseParent,
+            stashedSuspensePrevious,
+            stashedSuspenseRemaining,
+          );
+          // unmountSuspenseChildren already popped
+          shouldPopSuspenseNode = false;
+        } else {
+          if (contentFiberInstance !== null) {
+            throw new Error(
+              'A dehydrated Suspense node should not have a content Fiber.',
+            );
+          }
+        }
+      } else {
+        unmountRemainingChildren();
+      }
       removePreviousSuspendedBy(
         instance,
         previousSuspendedBy,
@@ -4049,7 +4103,7 @@ export function attach(
       reconcilingParent = stashedParent;
       previouslyReconciledSibling = stashedPrevious;
       remainingReconcilingChildren = stashedRemaining;
-      if (instance.suspenseNode !== null) {
+      if (shouldPopSuspenseNode) {
         reconcilingParentSuspenseNode = stashedSuspenseParent;
         previouslyReconciledSiblingSuspenseNode = stashedSuspensePrevious;
         remainingReconcilingChildrenSuspenseNodes = stashedSuspenseRemaining;
diff --git a/scripts/ci/download_devtools_regression_build.js b/scripts/ci/download_devtools_regression_build.js
index bdb2c0441b5c4..ed3c596a0efe0 100755
--- a/scripts/ci/download_devtools_regression_build.js
+++ b/scripts/ci/download_devtools_regression_build.js
@@ -9,7 +9,6 @@ const semver = require('semver');
 const yargs = require('yargs');
 const fs = require('fs');
 
-const INSTALL_PACKAGES = ['react-dom', 'react', 'react-test-renderer'];
 const REGRESSION_FOLDER = 'build-regression';
 
 const ROOT_PATH = join(__dirname, '..', '..');
@@ -23,6 +22,12 @@ const version = process.argv[2];
 const shouldReplaceBuild = !!argv.replaceBuild;
 
 async function downloadRegressionBuild() {
+  const reactVersion = semver.coerce(version).version;
+  const installPackages = ['react-dom', 'react', 'react-test-renderer'];
+  if (semver.gte(reactVersion, '16.3.0')) {
+    installPackages.push('react-is');
+  }
+
   console.log(chalk.bold.white(`Downloading React v${version}\n`));
 
   // Make build directory for temporary modules we're going to download
@@ -35,7 +40,7 @@ async function downloadRegressionBuild() {
   await exec(`mkdir ${regressionBuildPath}`);
 
   // Install all necessary React packages that have the same version
-  const downloadPackagesStr = INSTALL_PACKAGES.reduce(
+  const downloadPackagesStr = installPackages.reduce(
     (str, name) => `${str} ${name}@${version}`,
     ''
   );
@@ -51,7 +56,7 @@ async function downloadRegressionBuild() {
 
   // Remove all the packages that we downloaded in the original build folder
   // so we can move the modules from the regression build over
-  const removePackagesStr = INSTALL_PACKAGES.reduce(
+  const removePackagesStr = installPackages.reduce(
     (str, name) => `${str} ${join(buildPath, name)}`,
     ''
   );
@@ -63,12 +68,12 @@ async function downloadRegressionBuild() {
         .join(' ')}\n`
     )
   );
-  await exec(`rm -r ${removePackagesStr}`);
+  await exec(`rm -rf ${removePackagesStr}`);
 
   // Move all packages that we downloaded to the original build folder
   // We need to separately move the scheduler package because it might
   // be called schedule
-  const movePackageString = INSTALL_PACKAGES.reduce(
+  const movePackageString = installPackages.reduce(
     (str, name) => `${str} ${join(regressionBuildPath, 'node_modules', name)}`,
     ''
   );
@@ -80,9 +85,9 @@ async function downloadRegressionBuild() {
         .join(' ')} to ${chalk.underline.blue(buildPath)}\n`
     )
   );
+  fs.mkdirSync(buildPath, {recursive: true});
   await exec(`mv ${movePackageString} ${buildPath}`);
 
-  const reactVersion = semver.coerce(version).version;
   // For React versions earlier than 18.0.0, we explicitly scheduler v0.20.1, which
   // is the first version that has unstable_mock, which DevTools tests need, but also
   // has Scheduler.unstable_trace, which, although we don't use in DevTools tests
@@ -100,7 +105,7 @@ async function downloadRegressionBuild() {
     );
   } else {
     console.log(chalk.white(`Downloading scheduler\n`));
-    await exec(`rm -r ${join(buildPath, 'scheduler')}`);
+    await exec(`rm -rf ${join(buildPath, 'scheduler')}`);
     await exec(
       `mv ${join(
         regressionBuildPath,
@@ -134,8 +139,6 @@ async function main() {
       return;
     }
     await downloadRegressionBuild();
-  } catch (e) {
-    console.log(chalk.red(e));
   } finally {
     // We shouldn't remove the regression-build folder unless we're using
     // it to replace the build folder