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Vignette: Typos and grammar fixes.
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vignettes/pmp_vignette_signal_batch_correction_mass_spectrometry.Rmd

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---
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title: "Signal and batch correction for mass spectrometry"
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title: "Signal drift and batch effect correction for mass spectrometry"
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author:
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name: "Andris Jankevics"
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affiliation: Phenome Centre Birmingham, University of Birmingham
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bibliography: pmp.bib
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vignette: >
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%\VignetteIndexEntry{Signal and batch correction for mass spectrometry}
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%\VignetteIndexEntry{Signal drift and batch effect correction for mass spectrometry}
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%\VignetteEngine{knitr::rmarkdown}
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%\VignetteEncoding{UTF-8}
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---
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correction within/across a multi-batch direct infusion mass spectrometry (DIMS)
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and liquid chromatography mass spectrometry (LCMS) datasets.
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Please read "Signal and batch correction, data assessment and
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correction" vignette to learn how to assess your dataset and details on
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Please read "Signal drift and batch effect correction and mass spectral quality
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assessment" vignette to learn how to assess your dataset and details on
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algorithm itself.
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# Installation
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# Dataset
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In this tutorial we will be using an direct infusion mass spectrometry (DIMS)
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In this tutorial we will be using a direct infusion mass spectrometry (DIMS)
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dataset consisting of 172 samples measured across 8 batches and is included in
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`pmp` package as `SummarizedExperiemnt` class object `MTBLS79`.
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More detailed description of the dataset is available from @kirwan2014,
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The scores plots of principal components analysis (PCA) before
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and after correction can be used to asses effects of data correction.
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In this example, `PQN` method is used to normalise data,
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`KNN` for missing value imputation and `glog` for data scaling. All functions
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are availiable as a part of `r Biocpkg("pmp")` package.
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In this example, probabilistic quotient normalisation (`PQN`) method is used to
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normalise data, k-nearest neighbours (`KNN`) for missing value imputation and
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`glog` for data scaling. All functions are availiable as a part of
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`r Biocpkg("pmp")` package.
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A more detailed overview on data pre-processing is detailed in @guida2016.
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See @guida2016 for a more detailed review on common pre-processing steps and
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methods.
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```{r, fig.width=6, fig.height=8}
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