diff --git a/integration/query_response_compression_test.go b/integration/query_response_compression_test.go
index 58f54635190..8de7dafd1d6 100644
--- a/integration/query_response_compression_test.go
+++ b/integration/query_response_compression_test.go
@@ -6,10 +6,15 @@ package integration
 import (
 	"compress/gzip"
 	"fmt"
+	"strings"
+
 	"net/http"
+	"net/url"
+
 	"testing"
 	"time"
 
+	"github.com/prometheus/prometheus/prompb"
 	"github.com/stretchr/testify/require"
 
 	"github.com/cortexproject/cortex/integration/e2e"
@@ -17,7 +22,7 @@ import (
 	"github.com/cortexproject/cortex/integration/e2ecortex"
 )
 
-func TestQueryResponseCompression(t *testing.T) {
+func TestQuerierResponseCompression(t *testing.T) {
 	s, err := e2e.NewScenario(networkName)
 	require.NoError(t, err)
 	defer s.Close()
@@ -43,10 +48,16 @@ func TestQueryResponseCompression(t *testing.T) {
 	c, err := e2ecortex.NewClient(distributor.HTTPEndpoint(), "", "", "", "user-1")
 	require.NoError(t, err)
 
-	series, _ := generateSeries("series_1", now)
-	res, err := c.Push(series)
-	require.NoError(t, err)
-	require.Equal(t, 200, res.StatusCode)
+	for i := 0; i < 200; i++ {
+		series, _ := generateSeries(
+			fmt.Sprintf("series_%d", i),
+			now,
+			prompb.Label{Name: fmt.Sprintf("label_%d", i), Value: strings.Repeat("val_", 10)},
+		)
+		res, err := c.Push(series)
+		require.NoError(t, err)
+		require.Equal(t, 200, res.StatusCode)
+	}
 
 	querier := e2ecortex.NewQuerier("querier", e2ecortex.RingStoreConsul, consul.NetworkHTTPEndpoint(), flags, "")
 	require.NoError(t, s.StartAndWaitReady(querier))
@@ -54,7 +65,110 @@ func TestQueryResponseCompression(t *testing.T) {
 	// Wait until the querier has updated the ring.
 	require.NoError(t, querier.WaitSumMetrics(e2e.Equals(512), "cortex_ring_tokens_total"))
 
-	endpoint := fmt.Sprintf("http://%s/api/prom/api/v1/query?query=series_1", querier.HTTPEndpoint())
+	query := `{__name__=~"series_.*"}`
+	u := &url.URL{
+		Scheme: "http",
+		Path:   fmt.Sprintf("%s/api/prom/api/v1/query", querier.HTTPEndpoint()),
+	}
+	q := u.Query()
+	q.Set("query", query)
+	q.Set("time", e2ecortex.FormatTime(now))
+	u.RawQuery = q.Encode()
+	endpoint := u.String()
+
+	t.Run("Compressed", func(t *testing.T) {
+		req, err := http.NewRequest("GET", endpoint, nil)
+		require.NoError(t, err)
+		req.Header.Set("X-Scope-OrgID", "user-1")
+		req.Header.Set("Accept-Encoding", "gzip")
+
+		resp, err := http.DefaultClient.Do(req)
+		require.NoError(t, err)
+
+		defer resp.Body.Close()
+
+		require.Equal(t, http.StatusOK, resp.StatusCode)
+		require.Equal(t, "gzip", resp.Header.Get("Content-Encoding"))
+
+		gzipReader, err := gzip.NewReader(resp.Body)
+		require.NoError(t, err)
+		defer gzipReader.Close()
+	})
+
+	t.Run("Uncompressed", func(t *testing.T) {
+		req, err := http.NewRequest("GET", endpoint, nil)
+		require.NoError(t, err)
+		req.Header.Set("X-Scope-OrgID", "user-1")
+
+		resp, err := http.DefaultClient.Do(req)
+		require.NoError(t, err)
+		defer resp.Body.Close()
+
+		require.Equal(t, http.StatusOK, resp.StatusCode)
+		require.Empty(t, resp.Header.Get("Content-Encoding"))
+	})
+}
+
+func TestQueryFrontendResponseCompression(t *testing.T) {
+	s, err := e2e.NewScenario(networkName)
+	require.NoError(t, err)
+	defer s.Close()
+
+	// Start dependencies.
+	consul := e2edb.NewConsul()
+	minio := e2edb.NewMinio(9000, bucketName)
+	require.NoError(t, s.StartAndWaitReady(consul, minio))
+
+	flags := mergeFlags(BlocksStorageFlags(), map[string]string{
+		"-api.response-compression-enabled": "true",
+	})
+
+	// Start the query-frontend.
+	queryFrontend := e2ecortex.NewQueryFrontend("query-frontend", flags, "")
+	require.NoError(t, s.Start(queryFrontend))
+
+	distributor := e2ecortex.NewDistributor("distributor", e2ecortex.RingStoreConsul, consul.NetworkHTTPEndpoint(), flags, "")
+	ingester := e2ecortex.NewIngester("ingester", e2ecortex.RingStoreConsul, consul.NetworkHTTPEndpoint(), flags, "")
+	require.NoError(t, s.StartAndWaitReady(distributor, ingester))
+
+	// Wait until both the distributor updated the ring.
+	require.NoError(t, distributor.WaitSumMetrics(e2e.Equals(512), "cortex_ring_tokens_total"))
+
+	querier := e2ecortex.NewQuerier("querierWithFrontend", e2ecortex.RingStoreConsul, consul.NetworkHTTPEndpoint(), mergeFlags(flags, map[string]string{
+		"-querier.frontend-address": queryFrontend.NetworkGRPCEndpoint(),
+	}), "")
+
+	require.NoError(t, s.StartAndWaitReady(querier))
+	require.NoError(t, s.WaitReady(queryFrontend))
+
+	now := time.Now()
+
+	c, err := e2ecortex.NewClient(distributor.HTTPEndpoint(), queryFrontend.HTTPEndpoint(), "", "", "user-1")
+	require.NoError(t, err)
+
+	for i := 0; i < 200; i++ {
+		series, _ := generateSeries(
+			fmt.Sprintf("series_%d", i),
+			now,
+			prompb.Label{Name: fmt.Sprintf("label_%d", i), Value: strings.Repeat("val_", 10)},
+		)
+		res, err := c.Push(series)
+		require.NoError(t, err)
+		require.Equal(t, 200, res.StatusCode)
+	}
+
+	require.NoError(t, querier.WaitSumMetrics(e2e.Equals(512), "cortex_ring_tokens_total"))
+
+	query := `{__name__=~"series_.*"}`
+	u := &url.URL{
+		Scheme: "http",
+		Path:   fmt.Sprintf("%s/api/prom/api/v1/query", queryFrontend.HTTPEndpoint()),
+	}
+	q := u.Query()
+	q.Set("query", query)
+	q.Set("time", e2ecortex.FormatTime(now))
+	u.RawQuery = q.Encode()
+	endpoint := u.String()
 
 	t.Run("Compressed", func(t *testing.T) {
 		req, err := http.NewRequest("GET", endpoint, nil)