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TomasKulhanekTomasKulhanek
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shortened long model name to ATC_level3 48 chars and ATC_name 32 chars
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‎Pharmacolibrary/Drugs/A_AlimentaryTractAndMetabolism/A01A_StomatologicalPreparations/A01AA02_SodiumMonofluorophosphat/SodiumMonofluorophosphat.mo‎

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within Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A01A_StomatologicalPreparations.A01AA02_SodiumMonofluorophosphat;
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model SodiumMonofluorophosphat
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extends Pharmacolibrary.Drugs.ATC.A.A01AA02;
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annotation (Documentation(
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info = "<html><body><table><tr><td>name:</td><td>SodiumMonofluorophosphate</td></tr><tr><td>ATC code:</td><td>A01AA02</td></tr><td>route:</td><td>oral</td></tr><tr><td>n-compartments</td><td>1</td></tr></table><p>Sodium monofluorophosphate is an inorganic salt commonly used in dental health as an active ingredient in toothpaste for the prevention of dental caries (tooth decay) due to its ability to provide fluoride ions that help remineralize tooth enamel. It is topically applied, generally considered safe, and is approved in many jurisdictions for use in oral hygiene products, though not primarily used systemically as a therapeutic drug.</p><h4>Pharmacokinetics</h4><p>Estimated oral pharmacokinetic parameters for a healthy adult population are provided due to lack of published PK data for sodium monofluorophosphate as a systemic drug; based on general fluoride absorption and elimination behavior.</p><h4>References</h4><ol></ol></body></html>",
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revisions = "<html><body><ul><li>06/2025 initial generated model</li></ul></body></html>",
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experiment (StartTime = 0, StopTime = 86400, Tolerance = 1e-9, Interval = 1)
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));
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end SodiumMonofluorophosphat;

‎Pharmacolibrary/Drugs/A_AlimentaryTractAndMetabolism/A01A_StomatologicalPreparations/A01AA02_SodiumMonofluorophosphat/package.mo‎

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within Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A01A_StomatologicalPreparations;
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package A01AA02_SodiumMonofluorophosphat
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extends Icons.PackageDrugs;
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end A01AA02_SodiumMonofluorophosphat;

‎Pharmacolibrary/Drugs/A_AlimentaryTractAndMetabolism/A01A_StomatologicalPreparations/A01AA02_SodiumMonofluorophosphat/package.order‎

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SodiumMonofluorophosphat

‎Pharmacolibrary/Drugs/A_AlimentaryTractAndMetabolism/A01A_StomatologicalPreparations/A01AA51_SodiumFluorideCombinatio/SodiumFluorideCombinatio.mo‎

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within Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A01A_StomatologicalPreparations.A01AA51_SodiumFluorideCombinatio;
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model SodiumFluorideCombinatio
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extends Pharmacolibrary.Drugs.ATC.A.A01AA51;
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annotation (Documentation(
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info = "<html><body><table><tr><td>name:</td><td>SodiumFluorideCombinations</td></tr><tr><td>ATC code:</td><td>A01AA51</td></tr><td>route:</td><td>oral</td></tr><tr><td>n-compartments</td><td>1</td></tr></table><p>Sodium fluoride, in combination with other agents, is typically used topically or systemically for the prevention of dental caries through the promotion of remineralization of tooth enamel. Its systemic use is less common nowadays, and its main indication is dental hygiene and prevention of cavities. It is generally regarded as safe when used as indicated, but systemic application is not routinely recommended for general populations in most countries today.</p><h4>Pharmacokinetics</h4><p>Estimated typical pharmacokinetics in healthy adults, based on available data for sodium fluoride; no direct studies found for combinations under ATC code A01AA51.</p><h4>References</h4><ol><li><p>Lin, YS, et al., &amp; Milgrom, P (2018). Pharmacokinetics of Iodine and Fluoride following Application of an Anticaries Varnish in Adults. <i>JDR clinical and translational research</i> 3(3) 238–245. DOI:<a href=\"https://doi.org/10.1177/2380084418771930\">10.1177/2380084418771930</a> PUBMED:<a href=\"https://pubmed.ncbi.nlm.nih.gov/30938600/\">https://pubmed.ncbi.nlm.nih.gov/30938600</a></p></li><li><p>Ivanoff, CS, et al., &amp; Garcia-Godoy, F (2013). Enhanced penetration of fluoride particles into bovine enamel by combining dielectrophoresis with AC electroosmosis. <i>Electrophoresis</i> 34(20-21) 2945–2955. DOI:<a href=\"https://doi.org/10.1002/elps.201300206\">10.1002/elps.201300206</a> PUBMED:<a href=\"https://pubmed.ncbi.nlm.nih.gov/23897721/\">https://pubmed.ncbi.nlm.nih.gov/23897721</a></p></li></ol></body></html>",
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revisions = "<html><body><ul><li>06/2025 initial generated model</li></ul></body></html>",
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experiment (StartTime = 0, StopTime = 86400, Tolerance = 1e-9, Interval = 1)
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));
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end SodiumFluorideCombinatio;

‎Pharmacolibrary/Drugs/A_AlimentaryTractAndMetabolism/A01A_StomatologicalPreparations/A01AA51_SodiumFluorideCombinatio/package.mo‎

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within Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A01A_StomatologicalPreparations;
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package A01AA51_SodiumFluorideCombinatio
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extends Icons.PackageDrugs;
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end A01AA51_SodiumFluorideCombinatio;

‎Pharmacolibrary/Drugs/A_AlimentaryTractAndMetabolism/A01A_StomatologicalPreparations/A01AA51_SodiumFluorideCombinatio/package.order‎

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SodiumFluorideCombinatio

‎Pharmacolibrary/Drugs/A_AlimentaryTractAndMetabolism/A01A_StomatologicalPreparations/A01AB53_ChlorhexidineAndCetylpyr/ChlorhexidineAndCetylpyr.mo‎

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within Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A01A_StomatologicalPreparations.A01AB53_ChlorhexidineAndCetylpyr;
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model ChlorhexidineAndCetylpyr
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extends Pharmacolibrary.Drugs.ATC.A.A01AB53;
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annotation (Documentation(
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info = "<html><body><table><tr><td>name:</td><td>ChlorhexidineAndCetylpyridinium</td></tr><tr><td>ATC code:</td><td>A01AB53</td></tr><td>route:</td><td>oral</td></tr><tr><td>n-compartments</td><td>1</td></tr></table><p>A fixed combination of chlorhexidine, a bisbiguanide antiseptic, and cetylpyridinium chloride, a quaternary ammonium compound. Used as an oral rinse or lozenge for its antibacterial and antiseptic effects to control dental plaque, reduce gingivitis, and maintain oral hygiene. Widely used in oral hygiene products and approved for dental use.</p><h4>Pharmacokinetics</h4><p>Pharmacokinetic parameters for the combination of chlorhexidine and cetylpyridinium are not directly reported in indexed literature. The following values are estimated, based on available data for similar antiseptics used as oral rinses in adults.</p><h4>References</h4><ol></ol></body></html>",
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revisions = "<html><body><ul><li>06/2025 initial generated model</li></ul></body></html>",
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experiment (StartTime = 0, StopTime = 86400, Tolerance = 1e-9, Interval = 1)
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));
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end ChlorhexidineAndCetylpyr;

‎Pharmacolibrary/Drugs/A_AlimentaryTractAndMetabolism/A01A_StomatologicalPreparations/A01AB53_ChlorhexidineAndCetylpyr/package.mo‎

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within Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A01A_StomatologicalPreparations;
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package A01AB53_ChlorhexidineAndCetylpyr
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extends Icons.PackageDrugs;
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end A01AB53_ChlorhexidineAndCetylpyr;

‎Pharmacolibrary/Drugs/A_AlimentaryTractAndMetabolism/A01A_StomatologicalPreparations/A01AB53_ChlorhexidineAndCetylpyr/package.order‎

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ChlorhexidineAndCetylpyr

‎Pharmacolibrary/Drugs/A_AlimentaryTractAndMetabolism/A02A_Antacids/A02AA10_CimetidineAndAntacidsCom/CimetidineAndAntacidsCom.mo‎

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within Pharmacolibrary.Drugs.A_AlimentaryTractAndMetabolism.A02A_Antacids.A02AA10_CimetidineAndAntacidsCom;
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model CimetidineAndAntacidsCom
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extends Pharmacolibrary.Drugs.ATC.A.A02AA10;
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annotation (Documentation(
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info = "<html><body><table><tr><td>name:</td><td>CimetidineAndAntacidsCombinations</td></tr><tr><td>ATC code:</td><td>A02AA10</td></tr><td>route:</td><td>oral</td></tr><tr><td>n-compartments</td><td>1</td></tr></table><p>This combination combines cimetidine, a histamine H2-receptor antagonist that inhibits gastric acid secretion, with antacids that neutralize existing stomach acidity. It was used for short-term treatment of duodenal ulcers and relief of heartburn due to acid indigestion. This particular combination is largely discontinued and is not widely approved or marketed today.</p><h4>Pharmacokinetics</h4><p>Pharmacokinetic estimates reported for a typical healthy adult population. No specific study found for the exact combination formulation; the PK values provided are based on cimetidine monotherapy, as antacids generally do not modify cimetidine kinetics substantially.</p><h4>References</h4><ol></ol></body></html>",
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revisions = "<html><body><ul><li>06/2025 initial generated model</li></ul></body></html>",
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experiment (StartTime = 0, StopTime = 86400, Tolerance = 1e-9, Interval = 1)
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));
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end CimetidineAndAntacidsCom;

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