diff --git a/.coveragerc b/.coveragerc
index 30d2e5a5c..012c579b3 100644
--- a/.coveragerc
+++ b/.coveragerc
@@ -2,4 +2,4 @@
 branch = 1
 
 [report]
-omit = .tox*,*tests*,*migrations*
+omit = *tests*,*migrations*
diff --git a/.github/workflows/tests.yml b/.github/workflows/tests.yml
index 7cbef817c..9a9857e38 100644
--- a/.github/workflows/tests.yml
+++ b/.github/workflows/tests.yml
@@ -10,12 +10,6 @@ on:
 jobs:
     tests:
         runs-on: ubuntu-24.04
-        strategy:
-            fail-fast: false
-            matrix:
-                # tox-gh-actions will only run the tox environments which match the currently
-                # running python-version. See [gh-actions] in tox.ini for the mapping.
-                python-version: ["3.12"]
 
         services:
             postgres:
@@ -35,10 +29,11 @@ jobs:
             - name: Set up Python
               uses: actions/setup-python@v5
               with:
-                  python-version: "${{ matrix.python-version }}"
+                  python-version: 3.12
             - name: Install dependencies
               run: |
-                  python -m pip install --upgrade pip setuptools coveralls "tox<5" "tox-gh-actions<4"
+                  python -m pip install --upgrade pip setuptools coveralls
+                  python -m pip install -r requirements/tests.txt
             - name: Set up databases
               run: |
                   PGPASSWORD="postgres" createuser -U postgres -d djangoproject --superuser -h localhost
@@ -59,9 +54,9 @@ jobs:
                   echo '"trac_db_host": "localhost", ' >> conf/secrets.json
                   echo '"trac_db_password": "secret", ' >> conf/secrets.json
                   echo '"secret_key": "a"}' >> conf/secrets.json
-            - name: Run tox
+            - name: Run tests
               run: |
-                  python -m tox
+                  make ci
             - name: Coveralls
               env:
                   GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }}
diff --git a/.gitignore b/.gitignore
index 005ef51df..bb11a2c95 100644
--- a/.gitignore
+++ b/.gitignore
@@ -12,7 +12,6 @@ locale/*/LC_MESSAGES/django.mo
 .coverage
 .direnv
 .envrc
-.tox
 djangoproject/cache
 djangoproject/static/css/*.map
 djangoproject/static/css/*.css
diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index 600c12bb8..ce966f6b4 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -61,10 +61,6 @@ repos:
       hooks:
           - id: djhtml
             files: .*/templates/.*\.html$
-    - repo: https://github.com/tox-dev/pyproject-fmt
-      rev: "v2.6.0"
-      hooks:
-          - id: pyproject-fmt
     - repo: https://github.com/mrtazz/checkmake.git
       rev: 0.2.2
       hooks:
diff --git a/README.rst b/README.rst
index ba77c4278..f547d6e55 100644
--- a/README.rst
+++ b/README.rst
@@ -130,16 +130,13 @@ Our test results can be found here:
 
 * https://github.com/django/djangoproject.com/actions
 
-For local development don't hesitate to install
-`tox <https://tox.readthedocs.io/>`_ to run the website's test suite.
-
 Then in the root directory (next to the ``manage.py`` file) run::
 
-    tox
+    make test
 
 Behind the scenes, this will run the usual ``python -m manage test`` management
 command with a preset list of apps that we want to test. We
-collect test coverage data as part of that tox run, to show the result
+collect test coverage data as part of that test run, to show the result
 simply run::
 
     python -m coverage report
@@ -364,7 +361,6 @@ Running Locally with Docker
 
 4. Run the tests::
 
-    docker compose run --rm web tox
     docker compose run --rm web python -m manage test
 
 Pre-commit checks
diff --git a/requirements/tests.txt b/requirements/tests.txt
index 94cc982e1..476616f30 100644
--- a/requirements/tests.txt
+++ b/requirements/tests.txt
@@ -2,4 +2,3 @@
 coverage==7.10.2
 requests-mock==1.12.1
 tblib>=3.0.0
-tox<5.0.0
diff --git a/setup.cfg b/setup.cfg
index a384033f7..a27517872 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -1,5 +1,5 @@
 [flake8]
-exclude = djangodocs,.tox,*/migrations/*,.direnv,.venv
+exclude = djangodocs,*/migrations/*,.direnv,.venv
 ignore = F405,W504,W503
 # black enforces an 88 char line length but in some edge cases it's unable to
 # do so, and in that case it creates an unresolvable E501 error. The solution
@@ -11,7 +11,7 @@ per-file-ignores =
 [isort]
 line_length = 88
 profile = black
-skip = .tox,djangodocs,.direnv,.venv
+skip = djangodocs,.direnv,.venv
 known_first_party = accounts,aggregator,blog,contact,dashboard,djangoproject,docs,foundation,fundraising,legacy,members,releases,svntogit,tracdb
 combine_as_imports = true
 include_trailing_comma = true
diff --git a/tox.ini b/tox.ini
deleted file mode 100644
index 62ae04e58..000000000
--- a/tox.ini
+++ /dev/null
@@ -1,15 +0,0 @@
-[tox]
-envlist =py{312}-{tests}
-skipsdist = true
-
-[gh-actions]
-python =
-    3.12: py312
-
-[testenv]
-allowlist_externals = make
-passenv = DJANGO_SETTINGS_MODULE
-deps =
-    tests: -r{toxinidir}/requirements/tests.txt
-commands =
-    tests: make ci