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If you use the official Anthropic C# SDK you can use server-side skills with IChatClient and MEAI like this:

var options = new ChatOptions
{
    ModelId = "claude-sonnet-4-5-20250929",
    MaxOutputTokens = 4096,
    Tools =
    [
        new BetaSkillParams { Type = BetaSkillParamsType.Anthropic, SkillID = "pptx", Version = "latest" }.AsAITool(),
        new BetaSkillParams { Type = BetaSkillParamsType.Anthropic, SkillID = "xlsx", Version = "latest" }.AsAITool(),
    ]
};

var response = await chatClient.GetResponseAsync(messages, options);

For client-side skills that follow the agentskill specification, I don't think it is possible to have one single pattern as there are several paradig…

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@andrew-vdb
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