diff --git a/src/Compatibility/Microsoft.DotNet.ApiSymbolExtensions/AssemblySymbolLoader.cs b/src/Compatibility/Microsoft.DotNet.ApiSymbolExtensions/AssemblySymbolLoader.cs
index 1d6921dd1f92..f90efb19f4ad 100644
--- a/src/Compatibility/Microsoft.DotNet.ApiSymbolExtensions/AssemblySymbolLoader.cs
+++ b/src/Compatibility/Microsoft.DotNet.ApiSymbolExtensions/AssemblySymbolLoader.cs
@@ -16,6 +16,22 @@ namespace Microsoft.DotNet.ApiSymbolExtensions
     /// </summary>
     public class AssemblySymbolLoader : IAssemblySymbolLoader
     {
+        // This is a list of dangling .NET Framework internal assemblies that should never get loaded.
+        private static readonly HashSet<string> s_assembliesToIgnore = [
+            "System.ServiceModel.Internals",
+            "Microsoft.Internal.Tasks.Dataflow",
+            "MSDATASRC",
+            "ADODB",
+            "Microsoft.StdFormat",
+            "stdole",
+            "PresentationUI",
+            "Microsoft.VisualBasic.Activities.Compiler",
+            "SMDiagnostics",
+            "System.Xaml.Hosting",
+            "Microsoft.Transactions.Bridge",
+            "Microsoft.Workflow.Compiler"
+        ];
+
         private readonly ILog _log;
         // Dictionary that holds the paths to help loading dependencies. Keys will be assembly name and
         // value are the containing folder.
@@ -339,13 +355,18 @@ private void ResolveReferences(PEReader peReader, ImmutableHashSet<string>? refe
             foreach (AssemblyReferenceHandle handle in reader.AssemblyReferences)
             {
                 AssemblyReference reference = reader.GetAssemblyReference(handle);
-                string name = $"{reader.GetString(reference.Name)}.dll";
+                string nameWithoutExtension = reader.GetString(reference.Name);
+
+                // Skip assemblies that should never get loaded because they are purely internal
+                if (s_assembliesToIgnore.Contains(nameWithoutExtension))
+                    continue;
+
+                string name = nameWithoutExtension + ".dll";
 
                 // Skip reference assemblies that are loaded later.
                 if (referenceAssemblyNamesToIgnore != null && referenceAssemblyNamesToIgnore.Contains(name))
                     continue;
 
-
                 // If the assembly reference is already loaded, don't do anything.
                 if (_loadedAssemblies.ContainsKey(name))
                     continue;