diff --git a/lib/dry/cli/command.rb b/lib/dry/cli/command.rb
index 3e6a601..68a7da1 100644
--- a/lib/dry/cli/command.rb
+++ b/lib/dry/cli/command.rb
@@ -312,6 +312,54 @@ def self.option(name, options = {})
         @options << Option.new(name, options)
       end
 
+      # Mutually exclusive options (aka options that cannot be used together)
+      #
+      # @param options [Array] options that cannot be used together
+      #
+      # @since 1.3.0
+      #
+      # @example Basic usage
+      #   require "dry/cli"
+      #
+      #   class Greetings < Dry::CLI::Command
+      #     mutually_exclusive_options [
+      #       [:english, {desc: "Chooses English", type: :flag}],
+      #       [:spanish, {desc: "Chooses Spanish", type: :flag}],
+      #       [:portuguese, {desc: "Chooses Portuguese", type: :flag}]
+      #     ]
+      #
+      #     def call(options)
+      #       if options.key?(:english)
+      #         puts "Good morning"
+      #       elsif options.key?(:spanish)
+      #         puts "Buenos días"
+      #       elsif options.key?(:portuguese)
+      #         puts "Bom dia"
+      #       end
+      #     end
+      #   end
+      #
+      #   # $ foo greetings --english
+      #   # Good morning
+      #
+      #   # $ foo greetings --english --spanish
+      #   # ERROR: "foo greetings" was called with arguments "--english --spanish"
+      def self.mutually_exclusive_options(opts)
+        names = opts.map { _1[0] }
+
+        opts.each do |o|
+          current_name, current_opts = o
+          current_opts ||= {}
+
+          current_opts.merge!(
+            {
+              conflicts_with: names.reject { _1 == current_name }
+            }
+          )
+          option(current_name, current_opts)
+        end
+      end
+
       # @since 0.1.0
       # @api private
       def self.params
diff --git a/lib/dry/cli/errors.rb b/lib/dry/cli/errors.rb
index e9ca380..7f22577 100644
--- a/lib/dry/cli/errors.rb
+++ b/lib/dry/cli/errors.rb
@@ -9,6 +9,10 @@ class CLI
     class Error < StandardError
     end
 
+    # @since 1.3.0
+    class InvalidOptionCombination < Error
+    end
+
     # @since 0.2.1
     class UnknownCommandError < Error
       # @since 0.2.1
diff --git a/lib/dry/cli/option.rb b/lib/dry/cli/option.rb
index 710de98..1720b32 100644
--- a/lib/dry/cli/option.rb
+++ b/lib/dry/cli/option.rb
@@ -82,6 +82,12 @@ def description_name
         options[:label] || name.upcase
       end
 
+      # @since 1.3.0
+      # @api private
+      def conflicts_with
+        options[:conflicts_with] || []
+      end
+
       # @since 0.1.0
       # @api private
       def argument?
@@ -121,6 +127,15 @@ def alias_names
           .map { |name| name.size == 1 ? "-#{name}" : "--#{name}" }
           .map { |name| boolean? || flag? ? name : "#{name} VALUE" }
       end
+
+      # @since 1.3.0
+      # @api private
+      def conflicts_with?(opt)
+        candidates = conflicts_with
+        return false if candidates.empty?
+
+        candidates.include?(opt)
+      end
     end
 
     # Command line argument
diff --git a/lib/dry/cli/parser.rb b/lib/dry/cli/parser.rb
index aac127f..f065f8c 100644
--- a/lib/dry/cli/parser.rb
+++ b/lib/dry/cli/parser.rb
@@ -20,6 +20,9 @@ def self.call(command, arguments, prog_name)
         OptionParser.new do |opts|
           command.options.each do |option|
             opts.on(*option.parser_options) do |value|
+              conflict_found = parsed_options.keys.find { option.conflicts_with?(_1) }
+              raise InvalidOptionCombination if conflict_found
+
               parsed_options[option.name.to_sym] = value
             end
           end
@@ -31,7 +34,7 @@ def self.call(command, arguments, prog_name)
 
         parsed_options = command.default_params.merge(parsed_options)
         parse_required_params(command, arguments, prog_name, parsed_options)
-      rescue ::OptionParser::ParseError
+      rescue ::OptionParser::ParseError, InvalidOptionCombination
         Result.failure("ERROR: \"#{prog_name}\" was called with arguments \"#{original_arguments.join(" ")}\"") # rubocop:disable Layout/LineLength
       end
 
diff --git a/spec/support/fixtures/foo b/spec/support/fixtures/foo
index bf37e0f..ffacfbf 100755
--- a/spec/support/fixtures/foo
+++ b/spec/support/fixtures/foo
@@ -361,7 +361,10 @@ module Foo
       class Greeting < Dry::CLI::Command
         argument :response, default: "Hello World"
 
-        option :person
+        mutually_exclusive_options [
+          [:person],
+          [:alien, {desc: "Choose an alien", type: :string}]
+        ]
 
         def call(response:, **options)
           puts "response: #{response}, person: #{options[:person]}"
diff --git a/spec/support/fixtures/shared_commands.rb b/spec/support/fixtures/shared_commands.rb
index f694cd9..81e0a1f 100644
--- a/spec/support/fixtures/shared_commands.rb
+++ b/spec/support/fixtures/shared_commands.rb
@@ -342,7 +342,10 @@ def call(*)
   class Greeting < Dry::CLI::Command
     argument :response, default: "Hello World"
 
-    option :person
+    mutually_exclusive_options [
+      [:person],
+      [:alien, {desc: "Choose an alien", type: :string}]
+    ]
 
     def call(response:, **options)
       puts "response: #{response}, person: #{options[:person]}"
diff --git a/spec/support/shared_examples/commands.rb b/spec/support/shared_examples/commands.rb
index 4522201..98c1d16 100644
--- a/spec/support/shared_examples/commands.rb
+++ b/spec/support/shared_examples/commands.rb
@@ -26,6 +26,11 @@
     expect(output).to eq("generate secret - app: web\n")
   end
 
+  it "fails when using options that conflict" do
+    error = capture_error { cli.call(arguments: %w[greeting hello --person=Gustavo --alien=Orion]) }
+    expect(error).to eq("ERROR: \"rspec greeting\" was called with arguments \"hello --person=Gustavo --alien=Orion\"\n")
+  end
+
   context "works with params" do
     it "without params" do
       output = capture_output { cli.call(arguments: ["server"]) }
diff --git a/spec/unit/dry/cli/command_spec.rb b/spec/unit/dry/cli/command_spec.rb
new file mode 100644
index 0000000..99122a3
--- /dev/null
+++ b/spec/unit/dry/cli/command_spec.rb
@@ -0,0 +1,25 @@
+# frozen_string_literal: true
+
+RSpec.describe "Command" do
+  describe "#self.mutually_exclusive_options" do
+    class MutuallyExclusiveOpts < Dry::CLI::Command
+      mutually_exclusive_options [
+        [:steps, {desc: "Number of versions to rollback"}],
+        [:version, {desc: "The target version of the rollback (see `foo db version`)"}]
+      ]
+
+      def call(**); end
+    end
+
+    it "defines mutually exclusive options" do
+      c = MutuallyExclusiveOpts.new
+
+      opts = c.options
+      expect(opts.size).to eq(2)
+      expect(opts[0].name).to eq(:steps)
+      expect(opts[0].conflicts_with).to eq([:version])
+      expect(opts[1].name).to eq(:version)
+      expect(opts[1].conflicts_with).to eq([:steps])
+    end
+  end
+end
diff --git a/spec/unit/dry/cli/option_spec.rb b/spec/unit/dry/cli/option_spec.rb
new file mode 100644
index 0000000..f8e4c73
--- /dev/null
+++ b/spec/unit/dry/cli/option_spec.rb
@@ -0,0 +1,21 @@
+# frozen_string_literal: true
+
+RSpec.describe "Option" do
+  describe "#conflicts_with?" do
+    it "returns if the option/argument conflicts with the option/argument passed as the argument" do
+      opt = Dry::CLI::Option.new(:opt, {conflicts_with: %i[arg]})
+      arg = Dry::CLI::Argument.new(:arg, {conflicts_with: %i[a b]})
+      without_conflicts = Dry::CLI::Argument.new(:arg2)
+
+      expect(opt.conflicts_with?(:arg)).to eq(true)
+      expect(opt.conflicts_with?(:a)).to eq(false)
+      expect(arg.conflicts_with?(:a)).to eq(true)
+      expect(arg.conflicts_with?(:b)).to eq(true)
+      expect(arg.conflicts_with?(:opt)).to eq(false)
+      expect(without_conflicts.conflicts_with?(:opt)).to eq(false)
+      expect(without_conflicts.conflicts_with?(:arg)).to eq(false)
+      expect(without_conflicts.conflicts_with?(:a)).to eq(false)
+      expect(without_conflicts.conflicts_with?(:b)).to eq(false)
+    end
+  end
+end