diff --git a/CMakeLists.txt b/CMakeLists.txt
index ab9e1cee..fb412366 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -6,6 +6,7 @@ project(duckdb_py LANGUAGES CXX)
 set(CMAKE_CXX_STANDARD 11)
 set(CMAKE_CXX_STANDARD_REQUIRED ON)
 set(CMAKE_CXX_EXTENSIONS OFF)
+set(CMAKE_MSVC_RUNTIME_LIBRARY "MultiThreaded$<$<CONFIG:Debug>:Debug>")
 
 # Set the library name
 set(DUCKDB_PYTHON_LIB_NAME "_duckdb")
diff --git a/cmake/duckdb_loader.cmake b/cmake/duckdb_loader.cmake
index 2fc738fb..c9c77bb3 100644
--- a/cmake/duckdb_loader.cmake
+++ b/cmake/duckdb_loader.cmake
@@ -198,8 +198,6 @@ function(_duckdb_create_interface_target target_name)
         /wd26451
         /wd26495 # suppress Code Analysis
         /D_CRT_SECURE_NO_WARNINGS # suppress warnings about unsafe functions
-        /D_DISABLE_CONSTEXPR_MUTEX_CONSTRUCTOR # see
-                                               # https://github.com/duckdblabs/duckdb-internal/issues/5151
         /utf-8 # treat source files as UTF-8 encoded
     )
   elseif(CMAKE_SYSTEM_NAME STREQUAL "Darwin")