diff --git a/packages/rum-core/src/common/after-frame.js b/packages/rum-core/src/common/after-frame.js
index c9b545f28..f29ec7fa1 100644
--- a/packages/rum-core/src/common/after-frame.js
+++ b/packages/rum-core/src/common/after-frame.js
@@ -23,6 +23,8 @@
  *
  */
 
+import { runInOwnZone } from './utils'
+
 const RAF_TIMEOUT = 100
 
 /**
@@ -43,7 +45,7 @@ export default function afterFrame(callback) {
     cancelAnimationFrame(raf)
     setTimeout(callback)
   }
-  const timeout = setTimeout(handler, RAF_TIMEOUT)
+  const timeout = runInOwnZone(() => setTimeout(handler, RAF_TIMEOUT))
 
   const raf = requestAnimationFrame(handler)
 }
diff --git a/packages/rum-core/src/common/http/fetch.js b/packages/rum-core/src/common/http/fetch.js
index dee06aab7..ff6094de0 100644
--- a/packages/rum-core/src/common/http/fetch.js
+++ b/packages/rum-core/src/common/http/fetch.js
@@ -24,6 +24,7 @@
  */
 
 import { HTTP_REQUEST_TIMEOUT } from '../constants'
+import { runInOwnZone } from '../utils'
 import { isResponseSuccessful } from './response-status'
 
 // keepalive flag tends to limit the payload size to 64 KB
@@ -60,7 +61,7 @@ export function sendFetchRequest(
   if (typeof AbortController === 'function') {
     const controller = new AbortController()
     timeoutConfig.signal = controller.signal
-    setTimeout(() => controller.abort(), timeout)
+    runInOwnZone(() => setTimeout(() => controller.abort(), timeout))
   }
 
   let fetchResponse
diff --git a/packages/rum-core/src/common/queue.js b/packages/rum-core/src/common/queue.js
index 3843c0d07..9e917829f 100644
--- a/packages/rum-core/src/common/queue.js
+++ b/packages/rum-core/src/common/queue.js
@@ -23,6 +23,8 @@
  *
  */
 
+import { runInOwnZone } from './utils'
+
 class Queue {
   constructor(onFlush, opts = {}) {
     this.onFlush = onFlush
@@ -33,7 +35,9 @@ class Queue {
   }
 
   _setTimer() {
-    this.timeoutId = setTimeout(() => this.flush(), this.flushInterval)
+    this.timeoutId = runInOwnZone(() =>
+      setTimeout(() => this.flush(), this.flushInterval)
+    )
   }
 
   _clear() {
diff --git a/packages/rum-core/src/common/throttle.js b/packages/rum-core/src/common/throttle.js
index 5c129b2d7..d6d7c1f11 100644
--- a/packages/rum-core/src/common/throttle.js
+++ b/packages/rum-core/src/common/throttle.js
@@ -23,6 +23,8 @@
  *
  */
 
+import { runInOwnZone } from './utils'
+
 export default function throttle(fn, onThrottle, opts) {
   var context = this
   var limit = opts.limit
@@ -32,10 +34,12 @@ export default function throttle(fn, onThrottle, opts) {
   return function () {
     counter++
     if (typeof timeoutId === 'undefined') {
-      timeoutId = setTimeout(function () {
-        counter = 0
-        timeoutId = undefined
-      }, interval)
+      runInOwnZone(() => {
+        timeoutId = setTimeout(function () {
+          counter = 0
+          timeoutId = undefined
+        }, interval)
+      })
     }
     if (counter > limit && typeof onThrottle === 'function') {
       return onThrottle.apply(context, arguments)
diff --git a/packages/rum-core/src/common/utils.js b/packages/rum-core/src/common/utils.js
index bf2a7bc39..a77a002f2 100644
--- a/packages/rum-core/src/common/utils.js
+++ b/packages/rum-core/src/common/utils.js
@@ -431,6 +431,25 @@ function isBeaconInspectionEnabled() {
   return false
 }
 
+/**
+ * Run the given function in a separate zone if ZoneJs used.
+ * i.e. in Angular, where this can be used to let functions like `setTimeout` and `setInterval` not block the stabilization.
+ * (https://angular.io/api/core/ApplicationRef#isStable)
+ */
+function runInOwnZone(fn) {
+  if (typeof window.Zone === 'undefined') {
+    return fn()
+  }
+
+  if (!window.ApmZone) {
+    window.ApmZone = Zone.root.fork({
+      name: 'ApmZone'
+    })
+  }
+
+  return window.ApmZone.run(fn)
+}
+
 export {
   extend,
   merge,
@@ -470,5 +489,6 @@ export {
   isPerfTimelineSupported,
   isBrowser,
   isPerfTypeSupported,
-  isBeaconInspectionEnabled
+  isBeaconInspectionEnabled,
+  runInOwnZone
 }
diff --git a/packages/rum-core/src/index.js b/packages/rum-core/src/index.js
index 4d5efd001..18e978c69 100644
--- a/packages/rum-core/src/index.js
+++ b/packages/rum-core/src/index.js
@@ -32,7 +32,8 @@ import {
   isPlatformSupported,
   scheduleMicroTask,
   scheduleMacroTask,
-  isBrowser
+  isBrowser,
+  runInOwnZone
 } from './common/utils'
 import { patchAll, patchEventHandler } from './common/patching'
 import { observePageVisibility, observePageClicks } from './common/observers'
@@ -86,5 +87,6 @@ export {
   CLICK,
   bootstrap,
   observePageVisibility,
-  observePageClicks
+  observePageClicks,
+  runInOwnZone
 }