diff --git a/src/postamble_minimal.js b/src/postamble_minimal.js
index 5db4f2223c44d..8886506daf420 100644
--- a/src/postamble_minimal.js
+++ b/src/postamble_minimal.js
@@ -6,37 +6,49 @@
 
 // === Auto-generated postamble setup entry stuff ===
 #if HAS_MAIN // Only if user is exporting a C main(), we will generate a run() function that can be used to launch main.
-function run() {
-#if MEMORYPROFILER
-  emscriptenMemoryProfiler.onPreloadComplete();
-#endif
-
-  <<< ATMAINS >>>
-#if PROXY_TO_PTHREAD
-  // User requested the PROXY_TO_PTHREAD option, so call a stub main which
-  // pthread_create()s a new thread that will call the user's real main() for
-  // the application.
-  var ret = __emscripten_proxy_main();
-#else
-  var ret = _main();
 
 #if EXIT_RUNTIME
+function exitRuntime(ret) {
   <<< ATEXITS >>>
 #if PTHREADS
   PThread.terminateAllThreads();
 #endif
 
-#endif
-
-#if EXIT_RUNTIME
-
 #if ASSERTIONS
   runtimeExited = true;
 #endif
 
   _proc_exit(ret);
+
+#if STACK_OVERFLOW_CHECK
+  checkStackCookie();
 #endif
-#endif // PROXY_TO_PTHREAD
+}
+#endif
+
+function run() {
+#if MEMORYPROFILER
+  emscriptenMemoryProfiler.onPreloadComplete();
+#endif
+
+  <<< ATMAINS >>>
+
+#if PROXY_TO_PTHREAD
+  // User requested the PROXY_TO_PTHREAD option, so call a stub main which
+  // pthread_create()s a new thread that will call the user's real main() for
+  // the application.
+  __emscripten_proxy_main();
+#elif ASYNCIFY == 2 && EXIT_RUNTIME
+  // In JSPI-enabled build mode, the main() function will return a Promise,
+  // which resolves to the process exit code.
+  _main().then(exitRuntime);
+#elif EXIT_RUNTIME
+  // In regular exitRuntime mode, exit with the given return code from main().
+  exitRuntime(_main());
+#else
+  // Run a persistent (never-exiting) application starting at main().
+  _main();
+#endif 
 
 #if STACK_OVERFLOW_CHECK
   checkStackCookie();
@@ -95,6 +107,10 @@ function loadModule() {
   assignWasmImports();
 #endif
 
+#if ASYNCIFY
+Asyncify.instrumentWasmImports(wasmImports);
+#endif
+
 var imports = {
 #if MINIFY_WASM_IMPORTED_MODULES
   'a': wasmImports,
@@ -139,7 +155,7 @@ assert(Module['wasm'], 'Must load WebAssembly Module in to variable Module.wasm
 WebAssembly.instantiate(Module['wasm'], imports).then(/** @suppress {missingProperties} */ (output) => {
 #endif
 
-#if !LibraryManager.has('libexports.js')
+#if !LibraryManager.has('libexports.js') && ASYNCIFY != 1
   // If not using the emscripten_get_exported_function() API, keep the
   // `wasmExports` variable in local scope to this instantiate function to save
   // code size.  (otherwise access it without to export it to outer scope)
@@ -166,6 +182,10 @@ WebAssembly.instantiate(Module['wasm'], imports).then(/** @suppress {missingProp
   wasmExports = output.instance.exports;
 #endif
 
+#if ASYNCIFY
+  wasmExports = Asyncify.instrumentWasmExports(wasmExports);
+#endif
+
 #if MEMORY64 || CAN_ADDRESS_2GB
   wasmExports = applySignatureConversions(wasmExports);
 #endif
diff --git a/src/preamble_minimal.js b/src/preamble_minimal.js
index 6d19fcbfe2721..cc9d2fef8c578 100644
--- a/src/preamble_minimal.js
+++ b/src/preamble_minimal.js
@@ -11,8 +11,15 @@ function assert(condition, text) {
 }
 #endif
 
+#if ASYNCIFY == 1 // ASYNCIFY-mode requires checking ABORT variable to avoid operating if code has aborted during an unwind
+var ABORT = 0;
+#endif
+
 /** @param {string|number=} what */
 function abort(what) {
+#if ASYNCIFY == 1
+  ABORT = 1;
+#endif
   throw {{{ ASSERTIONS ? 'new Error(what)' : 'what' }}};
 }
 
diff --git a/test/test_browser.py b/test/test_browser.py
index 36ad411e2116c..67bd81289a135 100644
--- a/test/test_browser.py
+++ b/test/test_browser.py
@@ -3296,8 +3296,10 @@ def test_cocos2d_hello(self):
 
   @parameterized({
     'asyncify': (['-sASYNCIFY=1'],),
+    'asyncify_minimal_runtime': (['-sMINIMAL_RUNTIME', '-sASYNCIFY=1'],),
     'jspi': (['-sASYNCIFY=2', '-Wno-experimental'],),
     'jspi_wasm_bigint': (['-sASYNCIFY=2', '-sWASM_BIGINT', '-Wno-experimental'],),
+    'jspi_wasm_bigint_minimal_runtime': (['-sMINIMAL_RUNTIME', '-sASYNCIFY=2', '-sWASM_BIGINT', '-Wno-experimental'],),
   })
   def test_async(self, args):
     if is_jspi(args) and not is_chrome():