diff --git a/confection/_registry.py b/confection/_registry.py
index 49628da..1832858 100644
--- a/confection/_registry.py
+++ b/confection/_registry.py
@@ -268,7 +268,11 @@ def _make_unresolved_schema(
                 )
             elif field.annotation is None:
                 fields[name] = (Any, Field(field.default))
-            elif issubclass(field.annotation, BaseModel):
+            elif (
+                # On Python 3.10, typing.* objects were not classes
+                isinstance(field.annotation, type)
+                and issubclass(field.annotation, BaseModel)
+            ):
                 fields[name] = cls._make_unresolved_schema(
                     field.annotation, config[name]
                 )