diff --git a/compiler/packages/babel-plugin-react-compiler/src/Validation/ValidateNoDerivedComputationsInEffects_exp.ts b/compiler/packages/babel-plugin-react-compiler/src/Validation/ValidateNoDerivedComputationsInEffects_exp.ts
index 5cc9232ebfb..b0b680b0a9c 100644
--- a/compiler/packages/babel-plugin-react-compiler/src/Validation/ValidateNoDerivedComputationsInEffects_exp.ts
+++ b/compiler/packages/babel-plugin-react-compiler/src/Validation/ValidateNoDerivedComputationsInEffects_exp.ts
@@ -568,6 +568,26 @@ function renderTree(
   return result;
 }
 
+function getFnLocalDeps(
+  fn: FunctionExpression | undefined,
+): Set<IdentifierId> | undefined {
+  if (!fn) {
+    return undefined;
+  }
+
+  const deps: Set<IdentifierId> = new Set();
+
+  for (const [, block] of fn.loweredFunc.func.body.blocks) {
+    for (const instr of block.instructions) {
+      if (instr.value.kind === 'LoadLocal') {
+        deps.add(instr.value.place.identifier.id);
+      }
+    }
+  }
+
+  return deps;
+}
+
 function validateEffect(
   effectFunction: HIRFunction,
   context: ValidationContext,
@@ -586,8 +606,23 @@ function validateEffect(
     Set<SourceLocation>
   > = new Map();
 
+  let cleanUpFunctionDeps: Set<IdentifierId> | undefined;
+
   const globals: Set<IdentifierId> = new Set();
   for (const block of effectFunction.body.blocks.values()) {
+    /*
+     * if the block is in an effect and is of type return then its an effect's cleanup function
+     * if the cleanup function depends on a value from which effect-set state is derived then
+     * we can't validate
+     */
+    if (
+      block.terminal.kind === 'return' &&
+      block.terminal.returnVariant === 'Explicit'
+    ) {
+      cleanUpFunctionDeps = getFnLocalDeps(
+        context.functions.get(block.terminal.value.identifier.id),
+      );
+    }
     for (const pred of block.preds) {
       if (!seenBlocks.has(pred)) {
         // skip if block has a back edge
@@ -698,6 +733,12 @@ function validateEffect(
         ),
       );
 
+      for (const dep of derivedSetStateCall.sourceIds) {
+        if (cleanUpFunctionDeps !== undefined && cleanUpFunctionDeps.has(dep)) {
+          return;
+        }
+      }
+
       const propsArr = Array.from(propsSet);
       const stateArr = Array.from(stateSet);
 
diff --git a/compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/effect-derived-computations/effect-with-cleanup-function-depending-on-derived-computation-value.expect.md b/compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/effect-derived-computations/effect-with-cleanup-function-depending-on-derived-computation-value.expect.md
new file mode 100644
index 00000000000..e84031591e0
--- /dev/null
+++ b/compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/effect-derived-computations/effect-with-cleanup-function-depending-on-derived-computation-value.expect.md
@@ -0,0 +1,76 @@
+
+## Input
+
+```javascript
+// @validateNoDerivedComputationsInEffects_exp @loggerTestOnly
+
+import {useEffect, useState} from 'react';
+
+function Component(file: File) {
+  const [imageUrl, setImageUrl] = useState(null);
+
+  /*
+   * Cleaning up the variable or a source of the variable used to setState
+   * inside the effect communicates that we always need to clean up something
+   * which is a valid use case for useEffect. In which case we want to
+   * avoid an throwing
+   */
+  useEffect(() => {
+    const imageUrlPrepared = URL.createObjectURL(file);
+    setImageUrl(imageUrlPrepared);
+    return () => URL.revokeObjectURL(imageUrlPrepared);
+  }, [file]);
+
+  return <Image src={imageUrl} xstyle={styles.imageSizeLimits} />;
+}
+
+```
+
+## Code
+
+```javascript
+import { c as _c } from "react/compiler-runtime"; // @validateNoDerivedComputationsInEffects_exp @loggerTestOnly
+
+import { useEffect, useState } from "react";
+
+function Component(file) {
+  const $ = _c(5);
+  const [imageUrl, setImageUrl] = useState(null);
+  let t0;
+  let t1;
+  if ($[0] !== file) {
+    t0 = () => {
+      const imageUrlPrepared = URL.createObjectURL(file);
+      setImageUrl(imageUrlPrepared);
+      return () => URL.revokeObjectURL(imageUrlPrepared);
+    };
+    t1 = [file];
+    $[0] = file;
+    $[1] = t0;
+    $[2] = t1;
+  } else {
+    t0 = $[1];
+    t1 = $[2];
+  }
+  useEffect(t0, t1);
+  let t2;
+  if ($[3] !== imageUrl) {
+    t2 = <Image src={imageUrl} xstyle={styles.imageSizeLimits} />;
+    $[3] = imageUrl;
+    $[4] = t2;
+  } else {
+    t2 = $[4];
+  }
+  return t2;
+}
+
+```
+
+## Logs
+
+```
+{"kind":"CompileSuccess","fnLoc":{"start":{"line":5,"column":0,"index":108},"end":{"line":21,"column":1,"index":700},"filename":"effect-with-cleanup-function-depending-on-derived-computation-value.ts"},"fnName":"Component","memoSlots":5,"memoBlocks":2,"memoValues":3,"prunedMemoBlocks":0,"prunedMemoValues":0}
+```
+      
+### Eval output
+(kind: exception) Fixture not implemented
\ No newline at end of file
diff --git a/compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/effect-derived-computations/effect-with-cleanup-function-depending-on-derived-computation-value.js b/compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/effect-derived-computations/effect-with-cleanup-function-depending-on-derived-computation-value.js
new file mode 100644
index 00000000000..e419583cc6d
--- /dev/null
+++ b/compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/effect-derived-computations/effect-with-cleanup-function-depending-on-derived-computation-value.js
@@ -0,0 +1,21 @@
+// @validateNoDerivedComputationsInEffects_exp @loggerTestOnly
+
+import {useEffect, useState} from 'react';
+
+function Component(file: File) {
+  const [imageUrl, setImageUrl] = useState(null);
+
+  /*
+   * Cleaning up the variable or a source of the variable used to setState
+   * inside the effect communicates that we always need to clean up something
+   * which is a valid use case for useEffect. In which case we want to
+   * avoid an throwing
+   */
+  useEffect(() => {
+    const imageUrlPrepared = URL.createObjectURL(file);
+    setImageUrl(imageUrlPrepared);
+    return () => URL.revokeObjectURL(imageUrlPrepared);
+  }, [file]);
+
+  return <Image src={imageUrl} xstyle={styles.imageSizeLimits} />;
+}