In LCRS2, we ran our own script after building the output. It is run before building the actual images.
The script did this:
https://github.com/fairdk/lcrs2/blob/master/buildroot/postbuild.sh
Perhaps this is still the best and most flexible option. But it should ideally invoke python setup.py sdist to pack an actual distributed version of lcrs-embedded and then pip install it into a complete virtual environment of the host target with all dependencies?
Another option would be if there's somehow already a recipe for installing custom python packages and dependencies on a target system.