diff --git a/.github/actions/environment/action.yml b/.github/actions/environment/action.yml
index 5e4c5e836f..0ab866f67b 100644
--- a/.github/actions/environment/action.yml
+++ b/.github/actions/environment/action.yml
@@ -11,6 +11,12 @@ runs:
         echo "DOTNET_CLI_TELEMETRY_OPTOUT=1" >> $GITHUB_ENV
         echo "DOTNET_NOLOGO=1" >> $GITHUB_ENV
 
+    # Android SDK Build Tools are musl-incompatible
+    - name: Set Environment Variables for Alpine Linux
+      if: ${{ contains(matrix.container, 'alpine') }}
+      shell: bash
+      run: echo "NO_MOBILE=true" >> $GITHUB_ENV
+
     # zstd is needed for cross OS actions/cache but missing from windows-11-arm
     # https://github.com/actions/partner-runner-images/issues/99
     - name: Install zstd on Windows ARM64
@@ -26,18 +32,21 @@ runs:
 
     # Java 17 is needed for Android SDK setup step
     - name: Install Java 17
+      if: ${{ !matrix.container }}
       uses: actions/setup-java@v4
       with:
         distribution: ${{ runner.os == 'Windows' && runner.arch == 'ARM64' && 'microsoft' || 'temurin' }}
         java-version: '17'
 
     - name: Setup Android SDK
+      if: ${{ !matrix.container }}
       uses: android-actions/setup-android@07976c6290703d34c16d382cb36445f98bb43b1f # v3.2.0
       with:
         log-accepted-android-sdk-licenses: false
 
     # Java 11 is needed by .NET Android
     - name: Install Java 11
+      if: ${{ !matrix.container }}
       uses: actions/setup-java@v4
       with:
         distribution: ${{ runner.os == 'Windows' && runner.arch == 'ARM64' && 'microsoft' || 'temurin' }}
diff --git a/.github/workflows/build.yml b/.github/workflows/build.yml
index 8a85342b33..1cab070a6f 100644
--- a/.github/workflows/build.yml
+++ b/.github/workflows/build.yml
@@ -11,13 +11,17 @@ on:
 
 jobs:
   build-sentry-native:
-    name: sentry-native (${{ matrix.os }})
+    name: sentry-native (${{ matrix.container || matrix.os }})
     runs-on: ${{ matrix.os }}
+    container: ${{ matrix.container }}
     strategy:
       fail-fast: false
       matrix:
         include:
           - os: ubuntu-22.04 # Pin ubuntu to ensure mono is installed
+          - os: ubuntu-latest
+            target: Linux-musl
+            container: ghcr.io/getsentry/sentry-dotnet-alpine:3.21
           - os: macos-15 # Pin macos to get the version of Xcode that we need: https://github.com/actions/runner-images/issues/10703
           - os: windows-latest
           - os: windows-11-arm
@@ -44,10 +48,11 @@ jobs:
           enableCrossOsArchive: true
 
       - name: Remove unused applications
+        if: ${{ !matrix.container }}
         uses: ./.github/actions/freediskspace
 
       - name: Install build dependencies
-        if: steps.cache.outputs.cache-hit != 'true' && runner.os == 'Linux'
+        if: steps.cache.outputs.cache-hit != 'true' && runner.os == 'Linux' && !matrix.container
         run: |
           sudo apt update
           sudo apt install libcurl4-openssl-dev
@@ -58,14 +63,18 @@ jobs:
 
   build:
     needs: build-sentry-native
-    name: .NET (${{ matrix.os }})
+    name: .NET (${{ matrix.container || matrix.os }})
     runs-on: ${{ matrix.os }}
+    container: ${{ matrix.container }}
 
     strategy:
       fail-fast: false
       matrix:
         include:
           - os: ubuntu-22.04 # Pin ubuntu to ensure mono is installed
+          - os: ubuntu-latest
+            target: Linux-musl
+            container: ghcr.io/getsentry/sentry-dotnet-alpine:3.21
           - os: macos-15 # Pin macos to get the version of Xcode that we need: https://github.com/actions/runner-images/issues/10703
           - os: windows-latest
           - os: windows-11-arm
@@ -83,6 +92,7 @@ jobs:
           fetch-depth: 2 # default is 1 and codecov needs > 1
 
       - name: Remove unused applications
+        if: ${{ !matrix.container }}
         uses: ./.github/actions/freediskspace
 
       - name: Setup Environment
@@ -94,13 +104,21 @@ jobs:
         run: echo "CI_PUBLISHING_BUILD=true" >> $GITHUB_ENV
 
       - name: Download sentry-native (Linux)
-        if: ${{ (env.CI_PUBLISHING_BUILD == 'true') || (runner.os == 'Linux') }}
+        if: ${{ (env.CI_PUBLISHING_BUILD == 'true') || (runner.os == 'Linux' && !matrix.container) }}
         uses: actions/cache/restore@v4
         with:
           path: src/Sentry/Platforms/Native/sentry-native
           key: sentry-native-Linux-${{ hashFiles('scripts/build-sentry-native.ps1') }}-${{ hashFiles('.git/modules/modules/sentry-native/HEAD') }}
           fail-on-cache-miss: true
 
+      - name: Download sentry-native (Linux musl)
+        if: ${{ (env.CI_PUBLISHING_BUILD == 'true') || (matrix.target == 'Linux-musl') }}
+        uses: actions/cache/restore@v4
+        with:
+          path: src/Sentry/Platforms/Native/sentry-native
+          key: sentry-native-Linux-musl-${{ hashFiles('scripts/build-sentry-native.ps1') }}-${{ hashFiles('.git/modules/modules/sentry-native/HEAD') }}
+          fail-on-cache-miss: true
+
       - name: Download sentry-native (macOS)
         if: ${{ (env.CI_PUBLISHING_BUILD == 'true') || (runner.os == 'macOS') }}
         uses: actions/cache/restore@v4
@@ -128,6 +146,7 @@ jobs:
           enableCrossOsArchive: true
 
       - name: Build Native Dependencies
+        if: ${{ !matrix.container }}
         uses: ./.github/actions/buildnative
 
       - name: Restore .NET Dependencies
@@ -175,14 +194,17 @@ jobs:
 
   integration-test:
     needs: build
-    name: Integration test (${{ matrix.os }})
+    name: Integration test (${{ matrix.container || matrix.os }})
     runs-on: ${{ matrix.os }}
+    container: ${{ matrix.container }}
 
     strategy:
       fail-fast: false
       matrix:
         include:
           - os: ubuntu-22.04 # Pin ubuntu to ensure mono is installed
+          - os: ubuntu-latest
+            container: ghcr.io/getsentry/sentry-dotnet-alpine:3.21
           - os: macos-15 # Pin macos to get the version of Xcode that we need: https://github.com/actions/runner-images/issues/10703
           - os: windows-latest
           - os: windows-11-arm
@@ -204,7 +226,7 @@ jobs:
           path: src
 
       - name: Install build dependencies
-        if: runner.os == 'Linux'
+        if: runner.os == 'Linux' && !matrix.container
         run: |
           sudo apt update
           sudo apt install libcurl4-openssl-dev
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 3388c89041..18ce173165 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -1,5 +1,11 @@
 # Changelog
 
+## Unreleased
+
+### Fixes
+
+- Support musl on Linux ([#4188](https://github.com/getsentry/sentry-dotnet/pull/4188))
+
 ## 5.8.0
 
 ### Features
diff --git a/Sentry-CI-Build-Linux-musl.slnf b/Sentry-CI-Build-Linux-musl.slnf
new file mode 100644
index 0000000000..9d305e5df8
--- /dev/null
+++ b/Sentry-CI-Build-Linux-musl.slnf
@@ -0,0 +1,73 @@
+{
+  "solution": {
+    "path": "Sentry.sln",
+    "projects": [
+      "benchmarks\\Sentry.Benchmarks\\Sentry.Benchmarks.csproj",
+      "samples\\Sentry.Samples.AspNetCore.Basic\\Sentry.Samples.AspNetCore.Basic.csproj",
+      "samples\\Sentry.Samples.AspNetCore.Blazor.Server\\Sentry.Samples.AspNetCore.Blazor.Server.csproj",
+      "samples\\Sentry.Samples.AspNetCore.Blazor.Wasm\\Sentry.Samples.AspNetCore.Blazor.Wasm.csproj",
+      "samples\\Sentry.Samples.AspNetCore.Grpc\\Sentry.Samples.AspNetCore.Grpc.csproj",
+      "samples\\Sentry.Samples.AspNetCore.Mvc\\Sentry.Samples.AspNetCore.Mvc.csproj",
+      "samples\\Sentry.Samples.AspNetCore.Serilog\\Sentry.Samples.AspNetCore.Serilog.csproj",
+      "samples\\Sentry.Samples.AspNetCore.WebAPI.Profiling\\Sentry.Samples.AspNetCore.WebAPI.Profiling.csproj",
+      "samples\\Sentry.Samples.Aws.Lambda.AspNetCoreServer\\Sentry.Samples.Aws.Lambda.AspNetCoreServer.csproj",
+      "samples\\Sentry.Samples.Azure.Functions.Worker\\Sentry.Samples.Azure.Functions.Worker.csproj",
+      "samples\\Sentry.Samples.Console.Basic\\Sentry.Samples.Console.Basic.csproj",
+      "samples\\Sentry.Samples.Console.Customized\\Sentry.Samples.Console.Customized.csproj",
+      "samples\\Sentry.Samples.Console.HeapDump\\Sentry.Samples.Console.HeapDump.csproj",
+      "samples\\Sentry.Samples.Console.Native\\Sentry.Samples.Console.Native.csproj",
+      "samples\\Sentry.Samples.Console.Profiling\\Sentry.Samples.Console.Profiling.csproj",
+      "samples\\Sentry.Samples.EntityFramework\\Sentry.Samples.EntityFramework.csproj",
+      "samples\\Sentry.Samples.GenericHost\\Sentry.Samples.GenericHost.csproj",
+      "samples\\Sentry.Samples.Google.Cloud.Functions\\Sentry.Samples.Google.Cloud.Functions.csproj",
+      "samples\\Sentry.Samples.GraphQL.Client.Http\\Sentry.Samples.GraphQL.Client.Http.csproj",
+      "samples\\Sentry.Samples.GraphQL.Server\\Sentry.Samples.GraphQL.Server.csproj",
+      "samples\\Sentry.Samples.Hangfire\\Sentry.Samples.Hangfire.csproj",
+      "samples\\Sentry.Samples.Log4Net\\Sentry.Samples.Log4Net.csproj",
+      "samples\\Sentry.Samples.ME.Logging\\Sentry.Samples.ME.Logging.csproj",
+      "samples\\Sentry.Samples.NLog\\Sentry.Samples.NLog.csproj",
+      "samples\\Sentry.Samples.OpenTelemetry.AspNetCore\\Sentry.Samples.OpenTelemetry.AspNetCore.csproj",
+      "samples\\Sentry.Samples.OpenTelemetry.Console\\Sentry.Samples.OpenTelemetry.Console.csproj",
+      "samples\\Sentry.Samples.Serilog\\Sentry.Samples.Serilog.csproj",
+      "src\\Sentry.Analyzers\\Sentry.Analyzers.csproj",
+      "src\\Sentry.AspNetCore.Blazor.WebAssembly\\Sentry.AspNetCore.Blazor.WebAssembly.csproj",
+      "src\\Sentry.AspNetCore.Grpc\\Sentry.AspNetCore.Grpc.csproj",
+      "src\\Sentry.AspNetCore\\Sentry.AspNetCore.csproj",
+      "src\\Sentry.Azure.Functions.Worker\\Sentry.Azure.Functions.Worker.csproj",
+      "src\\Sentry.DiagnosticSource\\Sentry.DiagnosticSource.csproj",
+      "src\\Sentry.EntityFramework\\Sentry.EntityFramework.csproj",
+      "src\\Sentry.Extensions.Logging\\Sentry.Extensions.Logging.csproj",
+      "src\\Sentry.Google.Cloud.Functions\\Sentry.Google.Cloud.Functions.csproj",
+      "src\\Sentry.Hangfire\\Sentry.Hangfire.csproj",
+      "src\\Sentry.Log4Net\\Sentry.Log4Net.csproj",
+      "src\\Sentry.NLog\\Sentry.NLog.csproj",
+      "src\\Sentry.OpenTelemetry\\Sentry.OpenTelemetry.csproj",
+      "src\\Sentry.Profiling\\Sentry.Profiling.csproj",
+      "src\\Sentry.Serilog\\Sentry.Serilog.csproj",
+      "src\\Sentry.SourceGenerators\\Sentry.SourceGenerators.csproj",
+      "src\\Sentry\\Sentry.csproj",
+      "test\\Sentry.Analyzers.Tests\\Sentry.Analyzers.Tests.csproj",
+      "test\\Sentry.AspNet.Tests\\Sentry.AspNet.Tests.csproj",
+      "test\\Sentry.AspNetCore.Grpc.Tests\\Sentry.AspNetCore.Grpc.Tests.csproj",
+      "test\\Sentry.AspNetCore.Tests\\Sentry.AspNetCore.Tests.csproj",
+      "test\\Sentry.AspNetCore.TestUtils\\Sentry.AspNetCore.TestUtils.csproj",
+      "test\\Sentry.Azure.Functions.Worker.Tests\\Sentry.Azure.Functions.Worker.Tests.csproj",
+      "test\\Sentry.DiagnosticSource.IntegrationTests\\Sentry.DiagnosticSource.IntegrationTests.csproj",
+      "test\\Sentry.DiagnosticSource.Tests\\Sentry.DiagnosticSource.Tests.csproj",
+      "test\\Sentry.EntityFramework.Tests\\Sentry.EntityFramework.Tests.csproj",
+      "test\\Sentry.Extensions.Logging.Tests\\Sentry.Extensions.Logging.Tests.csproj",
+      "test\\Sentry.Google.Cloud.Functions.Tests\\Sentry.Google.Cloud.Functions.Tests.csproj",
+      "test\\Sentry.Hangfire.Tests\\Sentry.Hangfire.Tests.csproj",
+      "test\\Sentry.Log4Net.Tests\\Sentry.Log4Net.Tests.csproj",
+      "test\\Sentry.NLog.Tests\\Sentry.NLog.Tests.csproj",
+      "test\\Sentry.OpenTelemetry.Tests\\Sentry.OpenTelemetry.Tests.csproj",
+      "test\\Sentry.Profiling.Tests\\Sentry.Profiling.Tests.csproj",
+      "test\\Sentry.Serilog.Tests\\Sentry.Serilog.Tests.csproj",
+      "test\\Sentry.SourceGenerators.Tests\\Sentry.SourceGenerators.Tests.csproj",
+      "test\\Sentry.Testing.CrashableApp\\Sentry.Testing.CrashableApp.csproj",
+      "test\\Sentry.Testing\\Sentry.Testing.csproj",
+      "test\\Sentry.Tests\\Sentry.Tests.csproj",
+      "test\\SingleFileTestApp\\SingleFileTestApp.csproj"
+    ]
+  }
+}
diff --git a/integration-test/cli.Tests.ps1 b/integration-test/cli.Tests.ps1
index 5875adc44a..d5ce17efdc 100644
--- a/integration-test/cli.Tests.ps1
+++ b/integration-test/cli.Tests.ps1
@@ -2,6 +2,7 @@
 Set-StrictMode -Version Latest
 $ErrorActionPreference = 'Stop'
 . $PSScriptRoot/common.ps1
+$IsLinuxMusl = $IsLinux -and (ldd --version 2>&1) -match 'musl'
 
 Describe 'Console apps (<framework>) - normal build' -ForEach @(
     @{ framework = "net8.0" }
@@ -107,7 +108,7 @@ Describe 'Console apps (<framework>) - native AOT publish' -ForEach @(
 
 Describe 'MAUI' -ForEach @(
     @{ framework = "net8.0" }
-) {
+) -Skip:$IsLinuxMusl {
     BeforeAll {
         RegisterLocalPackage 'Sentry.Android.AssemblyReader'
         RegisterLocalPackage 'Sentry.Bindings.Android'
diff --git a/integration-test/runtime.Tests.ps1 b/integration-test/runtime.Tests.ps1
index 81f75fe245..047b5e9594 100644
--- a/integration-test/runtime.Tests.ps1
+++ b/integration-test/runtime.Tests.ps1
@@ -58,6 +58,10 @@ internal class FakeTransport : ITransport
                     return "./console-app/bin/Release/$framework/win-x64/publish/console-app.exe"
                 }
             }
+            elseif ((ldd --version 2>&1) -match 'musl')
+            {
+                return "./console-app/bin/Release/$framework/linux-musl-x64/publish/console-app"
+            }
             else
             {
                 return "./console-app/bin/Release/$framework/linux-x64/publish/console-app"
diff --git a/scripts/build-sentry-native.ps1 b/scripts/build-sentry-native.ps1
index 901399033d..50f58439f8 100644
--- a/scripts/build-sentry-native.ps1
+++ b/scripts/build-sentry-native.ps1
@@ -37,7 +37,14 @@ try
     }
     elseif ($IsLinux)
     {
-        $outDir += '/linux-x64'
+        if ((ldd --version 2>&1) -match 'musl')
+        {
+            $outDir += '/linux-musl-x64'
+        }
+        else
+        {
+            $outDir += '/linux-x64'
+        }
     }
     else
     {
diff --git a/scripts/generate-solution-filters-config.yaml b/scripts/generate-solution-filters-config.yaml
index 750b22c095..25752d7765 100644
--- a/scripts/generate-solution-filters-config.yaml
+++ b/scripts/generate-solution-filters-config.yaml
@@ -49,6 +49,21 @@ filterConfigs:
         - "**/*DeviceTests*.csproj"
         - "**/*Maui.Device.TestApp.csproj"
 
+  - outputPath: Sentry-CI-Build-Linux-musl.slnf
+    include:
+      groups:
+        - "allProjects"
+    exclude:
+      groups:
+        - "macOnly"
+        - "windowsOnly"
+        - "artefacts"
+        - "trimTests"
+      patterns:
+        - "**/*Android*.csproj"
+        - "**/*DeviceTests*.csproj"
+        - "**/*Maui*.csproj"
+
   - outputPath: Sentry-CI-Build-macOS.slnf
     include:
       groups:
diff --git a/src/Sentry/Platforms/Native/Sentry.Native.targets b/src/Sentry/Platforms/Native/Sentry.Native.targets
index a03d405f27..a3b365ef90 100644
--- a/src/Sentry/Platforms/Native/Sentry.Native.targets
+++ b/src/Sentry/Platforms/Native/Sentry.Native.targets
@@ -13,11 +13,14 @@
     <SentryNativeOutputDirectory-win-arm64>$(SentryNativeOutputDirectory)$(NativeLibRelativePath-win-arm64)\</SentryNativeOutputDirectory-win-arm64>
     <NativeLibRelativePath-linux-x64>linux-x64</NativeLibRelativePath-linux-x64>
     <SentryNativeOutputDirectory-linux-x64>$(SentryNativeOutputDirectory)$(NativeLibRelativePath-linux-x64)\</SentryNativeOutputDirectory-linux-x64>
+    <NativeLibRelativePath-linux-musl-x64>linux-musl-x64</NativeLibRelativePath-linux-musl-x64>
+    <SentryNativeOutputDirectory-linux-musl-x64>$(SentryNativeOutputDirectory)$(NativeLibRelativePath-linux-musl-x64)\</SentryNativeOutputDirectory-linux-musl-x64>
     <NativeLibRelativePath-osx>osx</NativeLibRelativePath-osx>
     <SentryNativeOutputDirectory-osx>$(SentryNativeOutputDirectory)$(NativeLibRelativePath-osx)\</SentryNativeOutputDirectory-osx>
     <SentryNativeBuildOutputs Condition="'$(RuntimeIdentifier)' == 'win-x64'">$(SentryNativeOutputDirectory-win-x64)lib$(SentryNativeLibraryName).lib</SentryNativeBuildOutputs>
     <SentryNativeBuildOutputs Condition="'$(RuntimeIdentifier)' == 'win-arm64'">$(SentryNativeOutputDirectory-win-arm64)lib$(SentryNativeLibraryName).lib</SentryNativeBuildOutputs>
-    <SentryNativeBuildOutputs Condition="$([MSBuild]::IsOsPlatform('Linux'))">$(SentryNativeOutputDirectory-linux-x64)lib$(SentryNativeLibraryName).a</SentryNativeBuildOutputs>
+    <SentryNativeBuildOutputs Condition="'$(RuntimeIdentifier)' == 'linux-x64'">$(SentryNativeOutputDirectory-linux-x64)lib$(SentryNativeLibraryName).a</SentryNativeBuildOutputs>
+    <SentryNativeBuildOutputs Condition="'$(RuntimeIdentifier)' == 'linux-musl-x64'">$(SentryNativeOutputDirectory-linux-musl-x64)lib$(SentryNativeLibraryName).a</SentryNativeBuildOutputs>
     <SentryNativeBuildOutputs Condition="$([MSBuild]::IsOsPlatform('OSX'))">$(SentryNativeOutputDirectory-osx)lib$(SentryNativeLibraryName).a</SentryNativeBuildOutputs>
   </PropertyGroup>
 
@@ -42,13 +45,20 @@
     </None>
   </ItemGroup>
 
-  <ItemGroup Condition="'$(CI_PUBLISHING_BUILD)' == 'true' or $([MSBuild]::IsOsPlatform('Linux'))">
+  <ItemGroup Condition="'$(CI_PUBLISHING_BUILD)' == 'true' or '$(RuntimeIdentifier)' == 'linux-x64'">
     <None Include="$(SentryNativeOutputDirectory-linux-x64)lib$(SentryNativeLibraryName).a">
       <Pack>true</Pack>
       <PackagePath>\sentry-native\$(NativeLibRelativePath-linux-x64)</PackagePath>
     </None>
   </ItemGroup>
 
+  <ItemGroup Condition="'$(CI_PUBLISHING_BUILD)' == 'true' or '$(RuntimeIdentifier)' == 'linux-musl-x64'">
+    <None Include="$(SentryNativeOutputDirectory-linux-musl-x64)lib$(SentryNativeLibraryName).a">
+      <Pack>true</Pack>
+      <PackagePath>\sentry-native\$(NativeLibRelativePath-linux-musl-x64)</PackagePath>
+    </None>
+  </ItemGroup>
+
   <ItemGroup Condition="'$(CI_PUBLISHING_BUILD)' == 'true' or $([MSBuild]::IsOsPlatform('OSX'))">
     <None Include="$(SentryNativeOutputDirectory-osx)lib$(SentryNativeLibraryName).a">
       <Pack>true</Pack>
diff --git a/src/Sentry/Platforms/Native/buildTransitive/Sentry.Native.targets b/src/Sentry/Platforms/Native/buildTransitive/Sentry.Native.targets
index 7b3e800790..3e08ba467f 100644
--- a/src/Sentry/Platforms/Native/buildTransitive/Sentry.Native.targets
+++ b/src/Sentry/Platforms/Native/buildTransitive/Sentry.Native.targets
@@ -40,6 +40,16 @@
     <NativeSystemLibrary Include="curl" />
   </ItemGroup>
 
+  <ItemGroup Condition="'$(FrameworkSupportsNative)' == 'true' and '$(RuntimeIdentifier)' == 'linux-musl-x64'">
+    <DirectPInvoke Include="sentry-native" />
+    <!-- When musl is detected, static sentry-native links to static libunwind -->
+    <LinkerArg Include="-Wl,-Bstatic -Wl,--whole-archive -lunwind -Wl,--no-whole-archive -Wl,-Bdynamic" />
+    <NativeSystemLibrary Include="lzma" />
+    <NativeLibrary Include="$(MSBuildThisFileDirectory)..\sentry-native\linux-musl-x64\libsentry-native.a" />
+    <!-- See: https://github.com/dotnet/runtime/issues/97414 -->
+    <NativeSystemLibrary Include="curl" />
+  </ItemGroup>
+
   <ItemGroup Condition="'$(FrameworkSupportsNative)' == 'true' and ('$(RuntimeIdentifier)' == 'osx-x64' or '$(RuntimeIdentifier)' == 'osx-arm64')">
     <DirectPInvoke Include="sentry-native" />
     <NativeLibrary Include="$(MSBuildThisFileDirectory)..\sentry-native\osx\libsentry-native.a" />