diff --git a/CHANGELOG.md b/CHANGELOG.md
index 719ce0d281..e8b9ca1f21 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -10,6 +10,7 @@
 ### Fixes
 
 - The SDK avoids redundant scope sync after transaction finish ([#4623](https://github.com/getsentry/sentry-dotnet/pull/4623))
+- sentry-native is now automatically disabled for WASM applications ([#4631](https://github.com/getsentry/sentry-dotnet/pull/4631))
 
 ## 6.0.0-preview.1
 
diff --git a/src/Sentry/Platforms/Native/buildTransitive/Sentry.Native.targets b/src/Sentry/Platforms/Native/buildTransitive/Sentry.Native.targets
index 792acfc289..7cfa67275d 100644
--- a/src/Sentry/Platforms/Native/buildTransitive/Sentry.Native.targets
+++ b/src/Sentry/Platforms/Native/buildTransitive/Sentry.Native.targets
@@ -24,6 +24,8 @@
     <FrameworkSupportsNative Condition="'$(RuntimeIdentifier)' == 'osx-x64' or '$(RuntimeIdentifier)' == 'osx-arm64'">true</FrameworkSupportsNative>
     <!-- net8.0 or greater -->
     <FrameworkSupportsNative Condition="'$(_SentryIsNet8OrGreater)' != 'true' or !('$(OutputType)' == 'Exe' or '$(OutputType)' == 'WinExe')">false</FrameworkSupportsNative>
+    <!-- WASM -->
+    <FrameworkSupportsNative Condition="'$(UsingMicrosoftNETSdkBlazorWebAssembly)' == 'true'">false</FrameworkSupportsNative>
     <!-- Make it opt-in/out -->
     <FrameworkSupportsNative Condition="'$(SentryNative)' == 'true' or '$(SentryNative)' == 'enable'">true</FrameworkSupportsNative>
     <FrameworkSupportsNative Condition="'$(SentryNative)' == 'false' or '$(SentryNative)' == 'disable'">false</FrameworkSupportsNative>
diff --git a/src/Sentry/buildTransitive/Sentry.targets b/src/Sentry/buildTransitive/Sentry.targets
index c33ed0efbf..8d24dc35b0 100644
--- a/src/Sentry/buildTransitive/Sentry.targets
+++ b/src/Sentry/buildTransitive/Sentry.targets
@@ -27,7 +27,7 @@
     <Error Text="Android projects using Sentry cannot build using AndroidEnableAssemblyCompression = false due to a Microsoft issue.  Please follow https://github.com/dotnet/android/issues/9752" />
   </Target>
 
-  <ItemGroup Condition="$([MSBuild]::IsOSPlatform('Windows'))">
+  <ItemGroup Condition="$([MSBuild]::IsOSPlatform('Windows')) AND '$(UsingMicrosoftNETSdkBlazorWebAssembly)' != 'true'">
     <!-- See: https://github.com/getsentry/sentry-dotnet/pull/4111 -->
     <LinkerArg Include="/NODEFAULTLIB:MSVCRT" />
   </ItemGroup>