diff --git a/dev-packages/browser-integration-tests/suites/integrations/globalHandlers/dataUrls/subject.js b/dev-packages/browser-integration-tests/suites/integrations/globalHandlers/dataUrls/subject.js
new file mode 100644
index 000000000000..0c22e79964df
--- /dev/null
+++ b/dev-packages/browser-integration-tests/suites/integrations/globalHandlers/dataUrls/subject.js
@@ -0,0 +1,11 @@
+const workerCode = `
+  self.addEventListener('message', (event) => {
+    if (event.data.type === 'error') {
+      throw new Error('Error thrown in worker');
+    }
+  });
+`;
+
+const worker = new Worker(`data:text/javascript;base64,${btoa(workerCode)}`);
+
+worker.postMessage({ type: 'error' });
diff --git a/dev-packages/browser-integration-tests/suites/integrations/globalHandlers/dataUrls/test.ts b/dev-packages/browser-integration-tests/suites/integrations/globalHandlers/dataUrls/test.ts
new file mode 100644
index 000000000000..e890ea128069
--- /dev/null
+++ b/dev-packages/browser-integration-tests/suites/integrations/globalHandlers/dataUrls/test.ts
@@ -0,0 +1,41 @@
+import { expect } from '@playwright/test';
+import { sentryTest } from '../../../../utils/fixtures';
+import { envelopeRequestParser, waitForErrorRequest } from '../../../../utils/helpers';
+
+/**
+ * Tests a special case where the `globalHandlersIntegration` itself creates a stack frame instead of using
+ * stack parsers. This is necessary because we don't always get an `error` object passed to `window.onerror`.
+ * @see `globalhandlers.ts#_enhanceEventWithInitialFrame`
+ */
+sentryTest('detects and handles data urls on first stack frame', async ({ getLocalTestUrl, page }) => {
+  const url = await getLocalTestUrl({ testDir: __dirname });
+
+  const errorEventPromise = waitForErrorRequest(page, e => {
+    return !!e.exception?.values;
+  });
+
+  await page.goto(url);
+
+  const errorEvent = envelopeRequestParser(await errorEventPromise);
+
+  expect(errorEvent?.exception?.values?.[0]).toEqual({
+    mechanism: {
+      handled: false,
+      synthetic: true,
+      type: 'auto.browser.global_handlers.onerror',
+    },
+    stacktrace: {
+      frames: [
+        {
+          colno: expect.any(Number), // webkit reports different colno than chromium
+          filename: '<data:text/javascript,base64>',
+          function: '?',
+          in_app: true,
+          lineno: 4,
+        },
+      ],
+    },
+    type: 'Error',
+    value: expect.stringMatching(/(Uncaught )?Error: Error thrown in worker/), // webikt throws without "Uncaught "
+  });
+});
diff --git a/packages/browser/src/integrations/globalhandlers.ts b/packages/browser/src/integrations/globalhandlers.ts
index ebfdff6d2f58..2aa29731a9b0 100644
--- a/packages/browser/src/integrations/globalhandlers.ts
+++ b/packages/browser/src/integrations/globalhandlers.ts
@@ -171,7 +171,7 @@ function _enhanceEventWithInitialFrame(
 
   const colno = column;
   const lineno = line;
-  const filename = isString(url) && url.length > 0 ? url : getLocationHref();
+  const filename = getFilenameFromUrl(url) ?? getLocationHref();
 
   // event.exception.values[0].stacktrace.frames
   if (ev0sf.length === 0) {
@@ -199,3 +199,20 @@ function getOptions(): { stackParser: StackParser; attachStacktrace?: boolean }
   };
   return options;
 }
+
+function getFilenameFromUrl(url: string | undefined): string | undefined {
+  if (!isString(url) || url.length === 0) {
+    return undefined;
+  }
+
+  // stack frame urls can be data urls, for example when initializing a Worker with a base64 encoded script
+  // in this case we just show the data prefix and mime type to avoid too long raw data urls
+  if (url.startsWith('data:')) {
+    const match = url.match(/^data:([^;]+)/);
+    const mimeType = match ? match[1] : 'text/javascript';
+    const isBase64 = url.includes('base64,');
+    return `<data:${mimeType}${isBase64 ? ',base64' : ''}>`;
+  }
+
+  return url.slice(0, 1024);
+}