diff --git a/dev-packages/node-integration-tests/suites/tracing/openai/scenario-azure-openai.mjs b/dev-packages/node-integration-tests/suites/tracing/openai/scenario-azure-openai.mjs
new file mode 100644
index 000000000000..6d519ae8b313
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/tracing/openai/scenario-azure-openai.mjs
@@ -0,0 +1,64 @@
+import express from 'express';
+import { AzureOpenAI } from 'openai';
+
+function startMockOpenAiServer() {
+  const app = express();
+  app.use(express.json());
+
+  app.post('/azureopenai/deployments/:model/chat/completions', (req, res) => {
+    res.send({
+      id: 'chatcmpl-mock123',
+      object: 'chat.completion',
+      created: 1677652288,
+      model: req.body.model,
+      system_fingerprint: 'fp_44709d6fcb',
+      choices: [
+        {
+          index: 0,
+          message: {
+            role: 'assistant',
+            content: 'Hello from OpenAI mock!',
+          },
+          finish_reason: 'stop',
+        },
+      ],
+      usage: {
+        prompt_tokens: 10,
+        completion_tokens: 15,
+        total_tokens: 25,
+      },
+    });
+  });
+  return new Promise(resolve => {
+    const server = app.listen(0, () => {
+      resolve(server);
+    });
+  });
+}
+
+async function run() {
+  const server = await startMockOpenAiServer();
+
+  const client = new AzureOpenAI({
+    baseURL: `http://localhost:${server.address().port}/azureopenai`,
+    apiKey: 'mock-api-key',
+    apiVersion: '2024-02-15-preview',
+  });
+
+  const response = await client.chat.completions.create({
+    model: 'gpt-3.5-turbo',
+    messages: [
+      { role: 'system', content: 'You are a helpful assistant.' },
+      { role: 'user', content: 'What is the capital of France?' },
+    ],
+    temperature: 0.7,
+    max_tokens: 100,
+  });
+
+  // eslint-disable-next-line no-console
+  console.log(JSON.stringify(response));
+
+  server.close();
+}
+
+run();
diff --git a/dev-packages/node-integration-tests/suites/tracing/openai/test.ts b/dev-packages/node-integration-tests/suites/tracing/openai/test.ts
index 116c3a6208fa..a0436d9e5a8b 100644
--- a/dev-packages/node-integration-tests/suites/tracing/openai/test.ts
+++ b/dev-packages/node-integration-tests/suites/tracing/openai/test.ts
@@ -501,6 +501,53 @@ describe('OpenAI integration', () => {
     });
   });
 
+  createEsmAndCjsTests(__dirname, 'scenario-azure-openai.mjs', 'instrument.mjs', (createRunner, test) => {
+    test('it works with Azure OpenAI', async () => {
+      await createRunner()
+        // First the span that our mock express server is emitting, unrelated to this test
+        .expect({
+          transaction: {
+            transaction: 'POST /azureopenai/deployments/:model/chat/completions',
+          },
+        })
+        .expect({
+          transaction: {
+            transaction: 'chat gpt-3.5-turbo',
+            contexts: {
+              trace: {
+                span_id: expect.any(String),
+                trace_id: expect.any(String),
+                data: {
+                  'gen_ai.operation.name': 'chat',
+                  'sentry.op': 'gen_ai.chat',
+                  'sentry.origin': 'auto.ai.openai',
+                  'gen_ai.system': 'openai',
+                  'gen_ai.request.model': 'gpt-3.5-turbo',
+                  'gen_ai.request.temperature': 0.7,
+                  'gen_ai.response.model': 'gpt-3.5-turbo',
+                  'gen_ai.response.id': 'chatcmpl-mock123',
+                  'gen_ai.response.finish_reasons': '["stop"]',
+                  'gen_ai.usage.input_tokens': 10,
+                  'gen_ai.usage.output_tokens': 15,
+                  'gen_ai.usage.total_tokens': 25,
+                  'openai.response.id': 'chatcmpl-mock123',
+                  'openai.response.model': 'gpt-3.5-turbo',
+                  'openai.response.timestamp': '2023-03-01T06:31:28.000Z',
+                  'openai.usage.completion_tokens': 15,
+                  'openai.usage.prompt_tokens': 10,
+                },
+                op: 'gen_ai.chat',
+                origin: 'auto.ai.openai',
+                status: 'ok',
+              },
+            },
+          },
+        })
+        .start()
+        .completed();
+    });
+  });
+
   createEsmAndCjsTests(
     __dirname,
     'truncation/scenario-message-truncation-completions.mjs',
diff --git a/dev-packages/node-integration-tests/suites/tracing/openai/v6/scenario-azure-openai.mjs b/dev-packages/node-integration-tests/suites/tracing/openai/v6/scenario-azure-openai.mjs
new file mode 100644
index 000000000000..6d519ae8b313
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/tracing/openai/v6/scenario-azure-openai.mjs
@@ -0,0 +1,64 @@
+import express from 'express';
+import { AzureOpenAI } from 'openai';
+
+function startMockOpenAiServer() {
+  const app = express();
+  app.use(express.json());
+
+  app.post('/azureopenai/deployments/:model/chat/completions', (req, res) => {
+    res.send({
+      id: 'chatcmpl-mock123',
+      object: 'chat.completion',
+      created: 1677652288,
+      model: req.body.model,
+      system_fingerprint: 'fp_44709d6fcb',
+      choices: [
+        {
+          index: 0,
+          message: {
+            role: 'assistant',
+            content: 'Hello from OpenAI mock!',
+          },
+          finish_reason: 'stop',
+        },
+      ],
+      usage: {
+        prompt_tokens: 10,
+        completion_tokens: 15,
+        total_tokens: 25,
+      },
+    });
+  });
+  return new Promise(resolve => {
+    const server = app.listen(0, () => {
+      resolve(server);
+    });
+  });
+}
+
+async function run() {
+  const server = await startMockOpenAiServer();
+
+  const client = new AzureOpenAI({
+    baseURL: `http://localhost:${server.address().port}/azureopenai`,
+    apiKey: 'mock-api-key',
+    apiVersion: '2024-02-15-preview',
+  });
+
+  const response = await client.chat.completions.create({
+    model: 'gpt-3.5-turbo',
+    messages: [
+      { role: 'system', content: 'You are a helpful assistant.' },
+      { role: 'user', content: 'What is the capital of France?' },
+    ],
+    temperature: 0.7,
+    max_tokens: 100,
+  });
+
+  // eslint-disable-next-line no-console
+  console.log(JSON.stringify(response));
+
+  server.close();
+}
+
+run();
diff --git a/dev-packages/node-integration-tests/suites/tracing/openai/v6/test.ts b/dev-packages/node-integration-tests/suites/tracing/openai/v6/test.ts
index 053f3066a1b0..4929325c6790 100644
--- a/dev-packages/node-integration-tests/suites/tracing/openai/v6/test.ts
+++ b/dev-packages/node-integration-tests/suites/tracing/openai/v6/test.ts
@@ -562,4 +562,62 @@ describe('OpenAI integration (V6)', () => {
       },
     },
   );
+
+  createEsmAndCjsTests(
+    __dirname,
+    'scenario-azure-openai.mjs',
+    'instrument.mjs',
+    (createRunner, test) => {
+      test('it works with Azure OpenAI (v6)', async () => {
+        await createRunner()
+          // First the span that our mock express server is emitting, unrelated to this test
+          .expect({
+            transaction: {
+              transaction: 'POST /azureopenai/deployments/:model/chat/completions',
+            },
+          })
+          .expect({
+            transaction: {
+              transaction: 'chat gpt-3.5-turbo',
+              contexts: {
+                trace: {
+                  span_id: expect.any(String),
+                  trace_id: expect.any(String),
+                  data: {
+                    'gen_ai.operation.name': 'chat',
+                    'sentry.op': 'gen_ai.chat',
+                    'sentry.origin': 'auto.ai.openai',
+                    'gen_ai.system': 'openai',
+                    'gen_ai.request.model': 'gpt-3.5-turbo',
+                    'gen_ai.request.temperature': 0.7,
+                    'gen_ai.response.model': 'gpt-3.5-turbo',
+                    'gen_ai.response.id': 'chatcmpl-mock123',
+                    'gen_ai.response.finish_reasons': '["stop"]',
+                    'gen_ai.usage.input_tokens': 10,
+                    'gen_ai.usage.output_tokens': 15,
+                    'gen_ai.usage.total_tokens': 25,
+                    'openai.response.id': 'chatcmpl-mock123',
+                    'openai.response.model': 'gpt-3.5-turbo',
+                    'openai.response.timestamp': '2023-03-01T06:31:28.000Z',
+                    'openai.usage.completion_tokens': 15,
+                    'openai.usage.prompt_tokens': 10,
+                  },
+                  op: 'gen_ai.chat',
+                  origin: 'auto.ai.openai',
+                  status: 'ok',
+                },
+              },
+            },
+          })
+          .start()
+          .completed();
+      });
+    },
+    {
+      additionalDependencies: {
+        openai: '6.0.0',
+        express: 'latest',
+      },
+    },
+  );
 });
diff --git a/packages/node/src/integrations/tracing/openai/instrumentation.ts b/packages/node/src/integrations/tracing/openai/instrumentation.ts
index e0682185ff0a..b1a577f9a5f4 100644
--- a/packages/node/src/integrations/tracing/openai/instrumentation.ts
+++ b/packages/node/src/integrations/tracing/openai/instrumentation.ts
@@ -25,6 +25,7 @@ export interface OpenAiIntegration extends Integration {
 interface PatchedModuleExports {
   [key: string]: unknown;
   OpenAI: abstract new (...args: unknown[]) => OpenAiClient;
+  AzureOpenAI?: abstract new (...args: unknown[]) => OpenAiClient;
 }
 
 /**
@@ -56,10 +57,23 @@ export class SentryOpenAiInstrumentation extends InstrumentationBase<Instrumenta
   }
 
   /**
-   * Core patch logic applying instrumentation to the OpenAI client constructor.
+   * Core patch logic applying instrumentation to the OpenAI and AzureOpenAI client constructors.
    */
   private _patch(exports: PatchedModuleExports): PatchedModuleExports | void {
-    const Original = exports.OpenAI;
+    let result = exports;
+    result = this._patchClient(result, 'OpenAI');
+    result = this._patchClient(result, 'AzureOpenAI');
+    return result;
+  }
+
+  /**
+   * Patch logic applying instrumentation to the specified client constructor.
+   */
+  private _patchClient(exports: PatchedModuleExports, exportKey: 'OpenAI' | 'AzureOpenAI'): PatchedModuleExports {
+    const Original = exports[exportKey];
+    if (!Original) {
+      return exports;
+    }
 
     const WrappedOpenAI = function (this: unknown, ...args: unknown[]) {
       // Check if wrapping should be skipped (e.g., when LangChain is handling instrumentation)
@@ -97,10 +111,10 @@ export class SentryOpenAiInstrumentation extends InstrumentationBase<Instrumenta
     // Constructor replacement - handle read-only properties
     // The OpenAI property might have only a getter, so use defineProperty
     try {
-      exports.OpenAI = WrappedOpenAI;
+      exports[exportKey] = WrappedOpenAI;
     } catch (error) {
       // If direct assignment fails, override the property descriptor
-      Object.defineProperty(exports, 'OpenAI', {
+      Object.defineProperty(exports, exportKey, {
         value: WrappedOpenAI,
         writable: true,
         configurable: true,