diff --git a/sentry_sdk/integrations/bottle.py b/sentry_sdk/integrations/bottle.py
index 148b86852e..8a9fc41208 100644
--- a/sentry_sdk/integrations/bottle.py
+++ b/sentry_sdk/integrations/bottle.py
@@ -177,14 +177,20 @@ def _set_transaction_name_and_source(event, transaction_style, request):
     name = ""
 
     if transaction_style == "url":
-        name = request.route.rule or ""
+        try:
+            name = request.route.rule or ""
+        except RuntimeError:
+            pass
 
     elif transaction_style == "endpoint":
-        name = (
-            request.route.name
-            or transaction_from_function(request.route.callback)
-            or ""
-        )
+        try:
+            name = (
+                request.route.name
+                or transaction_from_function(request.route.callback)
+                or ""
+            )
+        except RuntimeError:
+            pass
 
     event["transaction"] = name
     event["transaction_info"] = {"source": SOURCE_FOR_STYLE[transaction_style]}