diff --git a/requirements-testing.txt b/requirements-testing.txt
index 503ab5de68..cbc515eec2 100644
--- a/requirements-testing.txt
+++ b/requirements-testing.txt
@@ -14,4 +14,4 @@ socksio
 httpcore[http2]
 setuptools
 Brotli
-docker
\ No newline at end of file
+docker
diff --git a/scripts/populate_tox/tox.jinja b/scripts/populate_tox/tox.jinja
index 9da986a35a..5f1a26ac5e 100644
--- a/scripts/populate_tox/tox.jinja
+++ b/scripts/populate_tox/tox.jinja
@@ -384,6 +384,7 @@ deps =
     # Quart
     quart: quart-auth
     quart: pytest-asyncio
+    quart-{v0.19,latest}: quart-flask-patch
     quart-v0.16: blinker<1.6
     quart-v0.16: jinja2<3.1.0
     quart-v0.16: Werkzeug<2.1.0
diff --git a/sentry_sdk/integrations/flask.py b/sentry_sdk/integrations/flask.py
index 45b4f0b2b1..f45ec6db20 100644
--- a/sentry_sdk/integrations/flask.py
+++ b/sentry_sdk/integrations/flask.py
@@ -72,6 +72,18 @@ def __init__(
     @staticmethod
     def setup_once():
         # type: () -> None
+        try:
+            from quart import Quart  # type: ignore
+
+            if Flask == Quart:
+                # This is Quart masquerading as Flask, don't enable the Flask
+                # integration. See https://github.com/getsentry/sentry-python/issues/2709
+                raise DidNotEnable(
+                    "This is not a Flask app but rather Quart pretending to be Flask"
+                )
+        except ImportError:
+            pass
+
         version = package_version("flask")
         _check_minimum_version(FlaskIntegration, version)
 
diff --git a/tests/integrations/quart/test_quart.py b/tests/integrations/quart/test_quart.py
index f15b968ac5..100642d245 100644
--- a/tests/integrations/quart/test_quart.py
+++ b/tests/integrations/quart/test_quart.py
@@ -1,3 +1,4 @@
+import importlib
 import json
 import threading
 from unittest import mock
@@ -13,22 +14,22 @@
 from sentry_sdk.integrations.logging import LoggingIntegration
 import sentry_sdk.integrations.quart as quart_sentry
 
-from quart import Quart, Response, abort, stream_with_context
-from quart.views import View
 
-from quart_auth import AuthUser, login_user
-
-try:
-    from quart_auth import QuartAuth
+def quart_app_factory():
+    # These imports are inlined because the `test_quart_flask_patch` testcase
+    # tests behavior that is triggered by importing a package before any Quart
+    # imports happen, so we can't have these on the module level
+    from quart import Quart
 
-    auth_manager = QuartAuth()
-except ImportError:
-    from quart_auth import AuthManager
+    try:
+        from quart_auth import QuartAuth
 
-    auth_manager = AuthManager()
+        auth_manager = QuartAuth()
+    except ImportError:
+        from quart_auth import AuthManager
 
+        auth_manager = AuthManager()
 
-def quart_app_factory():
     app = Quart(__name__)
     app.debug = False
     app.config["TESTING"] = False
@@ -71,6 +72,42 @@ def integration_enabled_params(request):
         raise ValueError(request.param)
 
 
+@pytest.mark.asyncio
+@pytest.mark.forked
+@pytest.mark.skipif(
+    not importlib.util.find_spec("quart_flask_patch"),
+    reason="requires quart_flask_patch",
+)
+async def test_quart_flask_patch(sentry_init, capture_events, reset_integrations):
+    # This testcase is forked because `import quart_flask_patch` needs to run
+    # before anything else Quart-related is imported (since it monkeypatches
+    # some things) and we don't want this to affect other testcases.
+    #
+    # It's also important this testcase be run before any other testcase
+    # that uses `quart_app_factory`.
+    import quart_flask_patch  # noqa: F401
+
+    app = quart_app_factory()
+    sentry_init(
+        integrations=[quart_sentry.QuartIntegration()],
+    )
+
+    @app.route("/")
+    async def index():
+        1 / 0
+
+    events = capture_events()
+
+    client = app.test_client()
+    try:
+        await client.get("/")
+    except ZeroDivisionError:
+        pass
+
+    (event,) = events
+    assert event["exception"]["values"][0]["mechanism"]["type"] == "quart"
+
+
 @pytest.mark.asyncio
 async def test_has_context(sentry_init, capture_events):
     sentry_init(integrations=[quart_sentry.QuartIntegration()])
@@ -213,6 +250,8 @@ async def test_quart_auth_configured(
     monkeypatch,
     integration_enabled_params,
 ):
+    from quart_auth import AuthUser, login_user
+
     sentry_init(send_default_pii=send_default_pii, **integration_enabled_params)
     app = quart_app_factory()
 
@@ -368,6 +407,8 @@ async def error_handler(err):
 
 @pytest.mark.asyncio
 async def test_bad_request_not_captured(sentry_init, capture_events):
+    from quart import abort
+
     sentry_init(integrations=[quart_sentry.QuartIntegration()])
     app = quart_app_factory()
     events = capture_events()
@@ -385,6 +426,8 @@ async def index():
 
 @pytest.mark.asyncio
 async def test_does_not_leak_scope(sentry_init, capture_events):
+    from quart import Response, stream_with_context
+
     sentry_init(integrations=[quart_sentry.QuartIntegration()])
     app = quart_app_factory()
     events = capture_events()
@@ -514,6 +557,8 @@ async def error():
 
 @pytest.mark.asyncio
 async def test_class_based_views(sentry_init, capture_events):
+    from quart.views import View
+
     sentry_init(integrations=[quart_sentry.QuartIntegration()])
     app = quart_app_factory()
     events = capture_events()
diff --git a/tox.ini b/tox.ini
index 932ef256ab..2294fcc00b 100644
--- a/tox.ini
+++ b/tox.ini
@@ -501,6 +501,7 @@ deps =
     # Quart
     quart: quart-auth
     quart: pytest-asyncio
+    quart-{v0.19,latest}: quart-flask-patch
     quart-v0.16: blinker<1.6
     quart-v0.16: jinja2<3.1.0
     quart-v0.16: Werkzeug<2.1.0