diff --git a/sentry_sdk/integrations/clickhouse_driver.py b/sentry_sdk/integrations/clickhouse_driver.py
index 2561bfad04..bbaaaeec8e 100644
--- a/sentry_sdk/integrations/clickhouse_driver.py
+++ b/sentry_sdk/integrations/clickhouse_driver.py
@@ -11,7 +11,8 @@
 # without introducing a hard dependency on `typing_extensions`
 # from: https://stackoverflow.com/a/71944042/300572
 if TYPE_CHECKING:
-    from typing import ParamSpec, Callable
+    from collections.abc import Iterator
+    from typing import Any, ParamSpec, Callable
 else:
     # Fake ParamSpec
     class ParamSpec:
@@ -49,9 +50,7 @@ def setup_once() -> None:
         )
 
         # If the query contains parameters then the send_data function is used to send those parameters to clickhouse
-        clickhouse_driver.client.Client.send_data = _wrap_send_data(
-            clickhouse_driver.client.Client.send_data
-        )
+        _wrap_send_data()
 
         # Every query ends either with the Client's `receive_end_of_query` (no result expected)
         # or its `receive_result` (result expected)
@@ -128,23 +127,44 @@ def _inner_end(*args: P.args, **kwargs: P.kwargs) -> T:
     return _inner_end
 
 
-def _wrap_send_data(f: Callable[P, T]) -> Callable[P, T]:
-    def _inner_send_data(*args: P.args, **kwargs: P.kwargs) -> T:
-        instance = args[0]  # type: clickhouse_driver.client.Client
-        data = args[2]
-        span = getattr(instance.connection, "_sentry_span", None)
+def _wrap_send_data() -> None:
+    original_send_data = clickhouse_driver.client.Client.send_data
+
+    def _inner_send_data(  # type: ignore[no-untyped-def] # clickhouse-driver does not type send_data
+        self, sample_block, data, types_check=False, columnar=False, *args, **kwargs
+    ):
+        span = getattr(self.connection, "_sentry_span", None)
 
         if span is not None:
-            _set_db_data(span, instance.connection)
+            _set_db_data(span, self.connection)
 
             if should_send_default_pii():
                 db_params = span._data.get("db.params", [])
-                db_params.extend(data)
+
+                if isinstance(data, (list, tuple)):
+                    db_params.extend(data)
+
+                else:  # data is a generic iterator
+                    orig_data = data
+
+                    # Wrap the generator to add items to db.params as they are yielded.
+                    # This allows us to send the params to Sentry without needing to allocate
+                    # memory for the entire generator at once.
+                    def wrapped_generator() -> "Iterator[Any]":
+                        for item in orig_data:
+                            db_params.append(item)
+                            yield item
+
+                    # Replace the original iterator with the wrapped one.
+                    data = wrapped_generator()
+
                 span.set_data("db.params", db_params)
 
-        return f(*args, **kwargs)
+        return original_send_data(
+            self, sample_block, data, types_check, columnar, *args, **kwargs
+        )
 
-    return _inner_send_data
+    clickhouse_driver.client.Client.send_data = _inner_send_data
 
 
 def _set_db_data(
diff --git a/tests/integrations/clickhouse_driver/test_clickhouse_driver.py b/tests/integrations/clickhouse_driver/test_clickhouse_driver.py
index 0675ad9ff5..635f9334c4 100644
--- a/tests/integrations/clickhouse_driver/test_clickhouse_driver.py
+++ b/tests/integrations/clickhouse_driver/test_clickhouse_driver.py
@@ -342,6 +342,38 @@ def test_clickhouse_client_spans(
     assert event["spans"] == expected_spans
 
 
+def test_clickhouse_spans_with_generator(sentry_init, capture_events):
+    sentry_init(
+        integrations=[ClickhouseDriverIntegration()],
+        send_default_pii=True,
+        traces_sample_rate=1.0,
+    )
+    events = capture_events()
+
+    # Use a generator to test that the integration obtains values from the generator,
+    # without consuming the generator.
+    values = ({"x": i} for i in range(3))
+
+    with start_transaction(name="test_clickhouse_transaction"):
+        client = Client("localhost")
+        client.execute("DROP TABLE IF EXISTS test")
+        client.execute("CREATE TABLE test (x Int32) ENGINE = Memory")
+        client.execute("INSERT INTO test (x) VALUES", values)
+        res = client.execute("SELECT x FROM test")
+
+    # Verify that the integration did not consume the generator
+    assert res == [(0,), (1,), (2,)]
+
+    (event,) = events
+    spans = event["spans"]
+
+    [span] = [
+        span for span in spans if span["description"] == "INSERT INTO test (x) VALUES"
+    ]
+
+    assert span["data"]["db.params"] == [{"x": 0}, {"x": 1}, {"x": 2}]
+
+
 def test_clickhouse_client_spans_with_pii(
     sentry_init, capture_events, capture_envelopes
 ) -> None: