diff --git a/.github/workflows/test-integrations-misc.yml b/.github/workflows/test-integrations-misc.yml
index 5e10dc8b6c..10cccaebac 100644
--- a/.github/workflows/test-integrations-misc.yml
+++ b/.github/workflows/test-integrations-misc.yml
@@ -74,6 +74,10 @@ jobs:
         run: |
           set -x # print commands that are executed
           ./scripts/runtox.sh "py${{ matrix.python-version }}-typer"
+      - name: Test integration_deactivation
+        run: |
+          set -x # print commands that are executed
+          ./scripts/runtox.sh "py${{ matrix.python-version }}-integration_deactivation"
       - name: Generate coverage XML (Python 3.6)
         if: ${{ !cancelled() && matrix.python-version == '3.6' }}
         run: |
diff --git a/scripts/populate_tox/package_dependencies.jsonl b/scripts/populate_tox/package_dependencies.jsonl
index d467fc125c..254f42bbe1 100644
--- a/scripts/populate_tox/package_dependencies.jsonl
+++ b/scripts/populate_tox/package_dependencies.jsonl
@@ -1,18 +1,18 @@
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diff --git a/scripts/populate_tox/populate_tox.py b/scripts/populate_tox/populate_tox.py
index 0700a82637..2d81a85ea2 100644
--- a/scripts/populate_tox/populate_tox.py
+++ b/scripts/populate_tox/populate_tox.py
@@ -64,6 +64,7 @@
     "aws_lambda",
     "cloud_resource_context",
     "common",
+    "integration_deactivation",
     "gcp",
     "gevent",
     "opentelemetry",
diff --git a/scripts/populate_tox/releases.jsonl b/scripts/populate_tox/releases.jsonl
index 9cfa4137b7..8d57c183bf 100644
--- a/scripts/populate_tox/releases.jsonl
+++ b/scripts/populate_tox/releases.jsonl
@@ -47,7 +47,7 @@
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diff --git a/scripts/populate_tox/tox.jinja b/scripts/populate_tox/tox.jinja
index 4de4d94b5f..a04087ddfd 100755
--- a/scripts/populate_tox/tox.jinja
+++ b/scripts/populate_tox/tox.jinja
@@ -23,6 +23,9 @@ envlist =
     # === Gevent ===
     {py3.6,py3.8,py3.10,py3.11,py3.12}-gevent
 
+    # === Integration Deactivation ===
+    {py3.9,py3.10,py3.11,py3.12,py3.13,py3.14}-integration_deactivation
+
     # === Integrations ===
 
     # Asgi
@@ -88,6 +91,11 @@ deps =
     {py3.10,py3.11}-gevent: zope.event<5.0.0
     {py3.10,py3.11}-gevent: zope.interface<8.0
 
+    # === Integration Deactivation ===
+    integration_deactivation: openai
+    integration_deactivation: anthropic
+    integration_deactivation: langchain
+
     # === Integrations ===
 
     # Asgi
@@ -144,6 +152,7 @@ setenv =
     # TESTPATH definitions for test suites not managed by toxgen
     common: TESTPATH=tests
     gevent: TESTPATH=tests
+    integration_deactivation: TESTPATH=tests/test_ai_integration_deactivation.py
     asgi: TESTPATH=tests/integrations/asgi
     aws_lambda: TESTPATH=tests/integrations/aws_lambda
     cloud_resource_context: TESTPATH=tests/integrations/cloud_resource_context
diff --git a/scripts/split_tox_gh_actions/split_tox_gh_actions.py b/scripts/split_tox_gh_actions/split_tox_gh_actions.py
index 9f9369d4ab..59c3473d8c 100755
--- a/scripts/split_tox_gh_actions/split_tox_gh_actions.py
+++ b/scripts/split_tox_gh_actions/split_tox_gh_actions.py
@@ -154,6 +154,7 @@
         "pure_eval",
         "trytond",
         "typer",
+        "integration_deactivation",
     ],
 }
 
diff --git a/sentry_sdk/integrations/__init__.py b/sentry_sdk/integrations/__init__.py
index af4206e208..1de0b83c06 100644
--- a/sentry_sdk/integrations/__init__.py
+++ b/sentry_sdk/integrations/__init__.py
@@ -171,6 +171,11 @@ def iter_default_integrations(with_auto_enabling_integrations):
 }
 
 
+_INTEGRATION_DEACTIVATES = {
+    "langchain": {"openai", "anthropic"},
+}
+
+
 def setup_integrations(
     integrations,  # type: Sequence[Integration]
     with_defaults=True,  # type: bool
@@ -187,6 +192,15 @@ def setup_integrations(
 
     `disabled_integrations` takes precedence over `with_defaults` and
     `with_auto_enabling_integrations`.
+
+    Some integrations are designed to automatically deactivate other integrations
+    in order to avoid conflicts and prevent duplicate telemetry from being collected.
+    For example, enabling the `langchain` integration will auto-deactivate both the
+    `openai` and `anthropic` integrations.
+
+    Users can override this behavior by:
+      - Explicitly providing an integration in the `integrations=[]` list, or
+      - Disabling the higher-level integration via the `disabled_integrations` option.
     """
     integrations = dict(
         (integration.identifier, integration) for integration in integrations or ()
@@ -194,6 +208,8 @@ def setup_integrations(
 
     logger.debug("Setting up integrations (with default = %s)", with_defaults)
 
+    user_provided_integrations = set(integrations.keys())
+
     # Integrations that will not be enabled
     disabled_integrations = [
         integration if isinstance(integration, type) else type(integration)
@@ -212,6 +228,27 @@ def setup_integrations(
                 integrations[instance.identifier] = instance
                 used_as_default_integration.add(instance.identifier)
 
+    disabled_integration_identifiers = {
+        integration.identifier for integration in disabled_integrations
+    }
+
+    for integration, targets_to_deactivate in _INTEGRATION_DEACTIVATES.items():
+        if (
+            integration in integrations
+            and integration not in disabled_integration_identifiers
+        ):
+            for target in targets_to_deactivate:
+                if target not in user_provided_integrations:
+                    for cls in iter_default_integrations(True):
+                        if cls.identifier == target:
+                            if cls not in disabled_integrations:
+                                disabled_integrations.append(cls)
+                                logger.debug(
+                                    "Auto-deactivating %s integration because %s integration is active",
+                                    target,
+                                    integration,
+                                )
+
     for identifier, integration in integrations.items():
         with _installer_lock:
             if identifier not in _processed_integrations:
diff --git a/tests/test_ai_integration_deactivation.py b/tests/test_ai_integration_deactivation.py
new file mode 100644
index 0000000000..71ac4f70a9
--- /dev/null
+++ b/tests/test_ai_integration_deactivation.py
@@ -0,0 +1,222 @@
+import pytest
+
+from sentry_sdk import get_client
+from sentry_sdk.integrations import _INTEGRATION_DEACTIVATES
+
+
+try:
+    from sentry_sdk.integrations.langchain import LangchainIntegration
+
+    has_langchain = True
+except Exception:
+    has_langchain = False
+
+try:
+    from sentry_sdk.integrations.openai import OpenAIIntegration
+
+    has_openai = True
+except Exception:
+    has_openai = False
+
+try:
+    from sentry_sdk.integrations.anthropic import AnthropicIntegration
+
+    has_anthropic = True
+except Exception:
+    has_anthropic = False
+
+
+pytestmark = pytest.mark.skipif(
+    not (has_langchain and has_openai and has_anthropic),
+    reason="Requires langchain, openai, and anthropic packages to be installed",
+)
+
+
+def test_integration_deactivates_map_exists():
+    assert "langchain" in _INTEGRATION_DEACTIVATES
+    assert "openai" in _INTEGRATION_DEACTIVATES["langchain"]
+    assert "anthropic" in _INTEGRATION_DEACTIVATES["langchain"]
+
+
+def test_langchain_auto_deactivates_openai_and_anthropic(
+    sentry_init, reset_integrations
+):
+    sentry_init(
+        default_integrations=False,
+        auto_enabling_integrations=True,
+    )
+
+    client = get_client()
+    integration_types = {
+        type(integration) for integration in client.integrations.values()
+    }
+
+    if LangchainIntegration in integration_types:
+        assert OpenAIIntegration not in integration_types
+        assert AnthropicIntegration not in integration_types
+
+
+def test_user_can_override_with_explicit_openai(sentry_init, reset_integrations):
+    sentry_init(
+        default_integrations=False,
+        auto_enabling_integrations=True,
+        integrations=[OpenAIIntegration()],
+    )
+
+    client = get_client()
+    integration_types = {
+        type(integration) for integration in client.integrations.values()
+    }
+
+    assert OpenAIIntegration in integration_types
+
+
+def test_user_can_override_with_explicit_anthropic(sentry_init, reset_integrations):
+    sentry_init(
+        default_integrations=False,
+        auto_enabling_integrations=True,
+        integrations=[AnthropicIntegration()],
+    )
+
+    client = get_client()
+    integration_types = {
+        type(integration) for integration in client.integrations.values()
+    }
+
+    assert AnthropicIntegration in integration_types
+
+
+def test_user_can_override_with_both_explicit_integrations(
+    sentry_init, reset_integrations
+):
+    sentry_init(
+        default_integrations=False,
+        auto_enabling_integrations=True,
+        integrations=[OpenAIIntegration(), AnthropicIntegration()],
+    )
+
+    client = get_client()
+    integration_types = {
+        type(integration) for integration in client.integrations.values()
+    }
+
+    assert OpenAIIntegration in integration_types
+    assert AnthropicIntegration in integration_types
+
+
+def test_disabling_langchain_allows_openai_and_anthropic(
+    sentry_init, reset_integrations
+):
+    sentry_init(
+        default_integrations=False,
+        auto_enabling_integrations=True,
+        disabled_integrations=[LangchainIntegration],
+    )
+
+    client = get_client()
+    integration_types = {
+        type(integration) for integration in client.integrations.values()
+    }
+
+    assert LangchainIntegration not in integration_types
+
+
+def test_explicit_langchain_still_deactivates_others(sentry_init, reset_integrations):
+    sentry_init(
+        default_integrations=False,
+        auto_enabling_integrations=False,
+        integrations=[LangchainIntegration()],
+    )
+
+    client = get_client()
+    integration_types = {
+        type(integration) for integration in client.integrations.values()
+    }
+
+    if LangchainIntegration in integration_types:
+        assert OpenAIIntegration not in integration_types
+        assert AnthropicIntegration not in integration_types
+
+
+def test_langchain_and_openai_both_explicit_both_active(
+    sentry_init, reset_integrations
+):
+    sentry_init(
+        default_integrations=False,
+        auto_enabling_integrations=False,
+        integrations=[LangchainIntegration(), OpenAIIntegration()],
+    )
+
+    client = get_client()
+    integration_types = {
+        type(integration) for integration in client.integrations.values()
+    }
+
+    assert LangchainIntegration in integration_types
+    assert OpenAIIntegration in integration_types
+
+
+def test_no_langchain_means_openai_and_anthropic_can_auto_enable(
+    sentry_init, reset_integrations, monkeypatch
+):
+    import sys
+    import sentry_sdk.integrations
+
+    old_iter = sentry_sdk.integrations.iter_default_integrations
+
+    def filtered_iter(with_auto_enabling):
+        for cls in old_iter(with_auto_enabling):
+            if cls.identifier != "langchain":
+                yield cls
+
+    monkeypatch.setattr(
+        sentry_sdk.integrations, "iter_default_integrations", filtered_iter
+    )
+
+    sentry_init(
+        default_integrations=False,
+        auto_enabling_integrations=True,
+    )
+
+    client = get_client()
+    integration_types = {
+        type(integration) for integration in client.integrations.values()
+    }
+
+    assert LangchainIntegration not in integration_types
+
+
+def test_deactivation_with_default_integrations_enabled(
+    sentry_init, reset_integrations
+):
+    sentry_init(
+        default_integrations=True,
+        auto_enabling_integrations=True,
+    )
+
+    client = get_client()
+    integration_types = {
+        type(integration) for integration in client.integrations.values()
+    }
+
+    if LangchainIntegration in integration_types:
+        assert OpenAIIntegration not in integration_types
+        assert AnthropicIntegration not in integration_types
+
+
+def test_only_auto_enabling_integrations_without_defaults(
+    sentry_init, reset_integrations
+):
+    sentry_init(
+        default_integrations=False,
+        auto_enabling_integrations=True,
+    )
+
+    client = get_client()
+    integration_types = {
+        type(integration) for integration in client.integrations.values()
+    }
+
+    if LangchainIntegration in integration_types:
+        assert OpenAIIntegration not in integration_types
+        assert AnthropicIntegration not in integration_types
diff --git a/tox.ini b/tox.ini
index b0779ce57b..7a1fd39f03 100644
--- a/tox.ini
+++ b/tox.ini
@@ -23,6 +23,9 @@ envlist =
     # === Gevent ===
     {py3.6,py3.8,py3.10,py3.11,py3.12}-gevent
 
+    # === Integration Deactivation ===
+    {py3.9,py3.10,py3.11,py3.12,py3.13,py3.14}-integration_deactivation
+
     # === Integrations ===
 
     # Asgi
@@ -60,7 +63,7 @@ envlist =
     {py3.9,py3.12,py3.13}-google_genai-v1.29.0
     {py3.9,py3.12,py3.13}-google_genai-v1.35.0
     {py3.9,py3.12,py3.13}-google_genai-v1.41.0
-    {py3.9,py3.13,py3.14,py3.14t}-google_genai-v1.47.0
+    {py3.10,py3.13,py3.14,py3.14t}-google_genai-v1.48.0
 
     {py3.8,py3.10,py3.11}-huggingface_hub-v0.24.7
     {py3.8,py3.12,py3.13}-huggingface_hub-v0.36.0
@@ -88,11 +91,11 @@ envlist =
 
     {py3.8,py3.11,py3.12}-openai-base-v1.0.1
     {py3.8,py3.12,py3.13}-openai-base-v1.109.1
-    {py3.9,py3.12,py3.13}-openai-base-v2.6.1
+    {py3.9,py3.12,py3.13}-openai-base-v2.7.1
 
     {py3.8,py3.11,py3.12}-openai-notiktoken-v1.0.1
     {py3.8,py3.12,py3.13}-openai-notiktoken-v1.109.1
-    {py3.9,py3.12,py3.13}-openai-notiktoken-v2.6.1
+    {py3.9,py3.12,py3.13}-openai-notiktoken-v2.7.1
 
     {py3.10,py3.11,py3.12}-openai_agents-v0.0.19
     {py3.10,py3.12,py3.13}-openai_agents-v0.1.0
@@ -102,14 +105,14 @@ envlist =
     {py3.10,py3.12,py3.13}-pydantic_ai-v1.0.18
     {py3.10,py3.12,py3.13}-pydantic_ai-v1.3.0
     {py3.10,py3.12,py3.13}-pydantic_ai-v1.6.0
-    {py3.10,py3.12,py3.13}-pydantic_ai-v1.9.1
+    {py3.10,py3.12,py3.13}-pydantic_ai-v1.10.0
 
 
     # ~~~ Cloud ~~~
     {py3.6,py3.7}-boto3-v1.12.49
     {py3.6,py3.9,py3.10}-boto3-v1.20.54
     {py3.7,py3.11,py3.12}-boto3-v1.28.85
-    {py3.9,py3.13,py3.14,py3.14t}-boto3-v1.40.64
+    {py3.9,py3.13,py3.14,py3.14t}-boto3-v1.40.65
 
     {py3.6,py3.7,py3.8}-chalice-v1.16.0
     {py3.9,py3.12,py3.13}-chalice-v1.32.0
@@ -236,7 +239,7 @@ envlist =
     {py3.6,py3.9,py3.10}-fastapi-v0.79.1
     {py3.7,py3.10,py3.11}-fastapi-v0.93.0
     {py3.8,py3.10,py3.11}-fastapi-v0.107.0
-    {py3.8,py3.13,py3.14,py3.14t}-fastapi-v0.120.4
+    {py3.8,py3.13,py3.14,py3.14t}-fastapi-v0.121.0
 
 
     # ~~~ Web 2 ~~~
@@ -325,6 +328,11 @@ deps =
     {py3.10,py3.11}-gevent: zope.event<5.0.0
     {py3.10,py3.11}-gevent: zope.interface<8.0
 
+    # === Integration Deactivation ===
+    integration_deactivation: openai
+    integration_deactivation: anthropic
+    integration_deactivation: langchain
+
     # === Integrations ===
 
     # Asgi
@@ -365,7 +373,7 @@ deps =
     google_genai-v1.29.0: google-genai==1.29.0
     google_genai-v1.35.0: google-genai==1.35.0
     google_genai-v1.41.0: google-genai==1.41.0
-    google_genai-v1.47.0: google-genai==1.47.0
+    google_genai-v1.48.0: google-genai==1.48.0
     google_genai: pytest-asyncio
 
     huggingface_hub-v0.24.7: huggingface_hub==0.24.7
@@ -408,14 +416,14 @@ deps =
 
     openai-base-v1.0.1: openai==1.0.1
     openai-base-v1.109.1: openai==1.109.1
-    openai-base-v2.6.1: openai==2.6.1
+    openai-base-v2.7.1: openai==2.7.1
     openai-base: pytest-asyncio
     openai-base: tiktoken
     openai-base-v1.0.1: httpx<0.28
 
     openai-notiktoken-v1.0.1: openai==1.0.1
     openai-notiktoken-v1.109.1: openai==1.109.1
-    openai-notiktoken-v2.6.1: openai==2.6.1
+    openai-notiktoken-v2.7.1: openai==2.7.1
     openai-notiktoken: pytest-asyncio
     openai-notiktoken-v1.0.1: httpx<0.28
 
@@ -428,7 +436,7 @@ deps =
     pydantic_ai-v1.0.18: pydantic-ai==1.0.18
     pydantic_ai-v1.3.0: pydantic-ai==1.3.0
     pydantic_ai-v1.6.0: pydantic-ai==1.6.0
-    pydantic_ai-v1.9.1: pydantic-ai==1.9.1
+    pydantic_ai-v1.10.0: pydantic-ai==1.10.0
     pydantic_ai: pytest-asyncio
 
 
@@ -436,7 +444,7 @@ deps =
     boto3-v1.12.49: boto3==1.12.49
     boto3-v1.20.54: boto3==1.20.54
     boto3-v1.28.85: boto3==1.28.85
-    boto3-v1.40.64: boto3==1.40.64
+    boto3-v1.40.65: boto3==1.40.65
     {py3.7,py3.8}-boto3: urllib3<2.0.0
 
     chalice-v1.16.0: chalice==1.16.0
@@ -640,7 +648,7 @@ deps =
     fastapi-v0.79.1: fastapi==0.79.1
     fastapi-v0.93.0: fastapi==0.93.0
     fastapi-v0.107.0: fastapi==0.107.0
-    fastapi-v0.120.4: fastapi==0.120.4
+    fastapi-v0.121.0: fastapi==0.121.0
     fastapi: httpx
     fastapi: pytest-asyncio
     fastapi: python-multipart
@@ -760,6 +768,7 @@ setenv =
     # TESTPATH definitions for test suites not managed by toxgen
     common: TESTPATH=tests
     gevent: TESTPATH=tests
+    integration_deactivation: TESTPATH=tests/test_ai_integration_deactivation.py
     asgi: TESTPATH=tests/integrations/asgi
     aws_lambda: TESTPATH=tests/integrations/aws_lambda
     cloud_resource_context: TESTPATH=tests/integrations/cloud_resource_context