diff --git a/src/sentry/api/endpoints/api_application_details.py b/src/sentry/api/endpoints/api_application_details.py
index 8b83edaff192af..52d7a79be2ad24 100644
--- a/src/sentry/api/endpoints/api_application_details.py
+++ b/src/sentry/api/endpoints/api_application_details.py
@@ -1,3 +1,5 @@
+from urllib.parse import urlparse
+
 from django.db import router, transaction
 from rest_framework import serializers
 from rest_framework.authentication import SessionAuthentication
@@ -14,9 +16,37 @@
 from sentry.models.apiapplication import ApiApplication, ApiApplicationStatus
 
 
+class CustomSchemeURLField(serializers.CharField):
+    """URLField that accepts any valid scheme, not just HTTP/HTTPS."""
+
+    default_error_messages = {
+        "invalid": "Enter a valid URL.",
+    }
+
+    def run_validation(self, data):
+        # First run the standard CharField validations
+        data = super().run_validation(data)
+
+        if data is None:
+            return data
+
+        if data == "":
+            self.fail("invalid")
+
+        # Basic URL structure validation
+        try:
+            parsed = urlparse(data)
+            if not parsed.scheme or not parsed.netloc:
+                self.fail("invalid")
+        except Exception:
+            self.fail("invalid")
+
+        return data
+
+
 class ApiApplicationSerializer(serializers.Serializer):
     name = serializers.CharField(max_length=64)
-    redirectUris = ListField(child=serializers.URLField(max_length=255), required=False)
+    redirectUris = ListField(child=CustomSchemeURLField(max_length=255), required=False)
     allowedOrigins = ListField(
         # TODO(dcramer): make this validate origins
         child=serializers.CharField(max_length=255),
diff --git a/tests/sentry/api/endpoints/test_api_application_details.py b/tests/sentry/api/endpoints/test_api_application_details.py
index 12227be9aabd9d..a549e3b700f565 100644
--- a/tests/sentry/api/endpoints/test_api_application_details.py
+++ b/tests/sentry/api/endpoints/test_api_application_details.py
@@ -32,6 +32,51 @@ def test_simple(self) -> None:
         app = ApiApplication.objects.get(id=app.id)
         assert app.name == "foobaz"
 
+    def test_redirect_uris_with_custom_schemes(self) -> None:
+        app = ApiApplication.objects.create(owner=self.user, name="a")
+
+        self.login_as(self.user)
+        url = reverse("sentry-api-0-api-application-details", args=[app.client_id])
+
+        # Test various custom schemes
+        custom_uris = [
+            "myapp://callback",
+            "custom-scheme://auth/callback",
+            "app123://redirect",
+            "http://example.com/callback",  # Standard HTTP still works
+            "https://example.com/callback",  # Standard HTTPS still works
+        ]
+
+        response = self.client.put(url, data={"redirectUris": custom_uris})
+        assert response.status_code == 200, (response.status_code, response.content)
+
+        app = ApiApplication.objects.get(id=app.id)
+        saved_uris = app.get_redirect_uris()
+        assert len(saved_uris) == 5
+        assert "myapp://callback" in saved_uris
+        assert "custom-scheme://auth/callback" in saved_uris
+        assert "app123://redirect" in saved_uris
+        assert "http://example.com/callback" in saved_uris
+        assert "https://example.com/callback" in saved_uris
+
+    def test_invalid_redirect_uris_rejected(self) -> None:
+        app = ApiApplication.objects.create(owner=self.user, name="a")
+
+        self.login_as(self.user)
+        url = reverse("sentry-api-0-api-application-details", args=[app.client_id])
+
+        # Test invalid URIs
+        invalid_uris = [
+            "not-a-url",  # No scheme or netloc
+            "://missing-scheme.com",  # No scheme
+            "scheme-only://",  # No netloc
+            "",  # Empty string should be rejected
+        ]
+
+        response = self.client.put(url, data={"redirectUris": invalid_uris})
+        assert response.status_code == 400, (response.status_code, response.content)
+        assert "redirectUris" in response.data
+
 
 @control_silo_test
 class ApiApplicationDeleteTest(APITestCase):