diff --git a/ggml/src/ggml-cpu/arch-fallback.h b/ggml/src/ggml-cpu/arch-fallback.h
index 373408a9c0955..edfd7913903a6 100644
--- a/ggml/src/ggml-cpu/arch-fallback.h
+++ b/ggml/src/ggml-cpu/arch-fallback.h
@@ -160,7 +160,6 @@
 #define ggml_vec_dot_iq3_s_q8_K_generic ggml_vec_dot_iq3_s_q8_K
 #define ggml_vec_dot_iq1_s_q8_K_generic ggml_vec_dot_iq1_s_q8_K
 #define ggml_vec_dot_iq1_m_q8_K_generic ggml_vec_dot_iq1_m_q8_K
-#define ggml_vec_dot_mxfp4_q8_0_generic ggml_vec_dot_mxfp4_q8_0
 // repack.cpp
 #define ggml_quantize_mat_q8_0_4x4_generic ggml_quantize_mat_q8_0_4x4
 #define ggml_quantize_mat_q8_0_4x8_generic ggml_quantize_mat_q8_0_4x8
diff --git a/ggml/src/ggml-cpu/arch/s390/quants.c b/ggml/src/ggml-cpu/arch/s390/quants.c
index dc1bba3a3e272..a19ee68c13d64 100644
--- a/ggml/src/ggml-cpu/arch/s390/quants.c
+++ b/ggml/src/ggml-cpu/arch/s390/quants.c
@@ -260,6 +260,101 @@ void ggml_vec_dot_q4_1_q8_1(int n, float * GGML_RESTRICT s, size_t bs, const voi
 #endif
 }
 
+void ggml_vec_dot_mxfp4_q8_0(int n, float * GGML_RESTRICT s, size_t bs, const void * GGML_RESTRICT vx, size_t bx, const void * GGML_RESTRICT vy, size_t by, int nrc) {
+    assert(nrc == 1);
+    UNUSED(nrc);
+    UNUSED(bx);
+    UNUSED(by);
+    UNUSED(bs);
+    assert(n % QK_MXFP4 == 0);
+    static_assert(QK_MXFP4 == QK8_0, "QK_MXFP4 and QK8_0 must be the same");
+
+    const int qk = QK_MXFP4;
+    const int nb = n / qk;
+
+    const block_mxfp4 * GGML_RESTRICT x = vx;
+    const block_q8_0  * GGML_RESTRICT y = vy;
+
+    int ib = 0;
+    float sumf = 0.0f;
+
+#if defined(__VXE__) || defined(__VXE2__)
+    const int8x16_t  v_k = vec_xl(0, kvalues_mxfp4);
+    const uint8x16_t v_m = vec_splats((const uint8_t)0x0F);
+
+    float32x4_t v_acc = vec_splats(0.0f);
+
+    #pragma GCC unroll 8
+    for (; ib + 1 < nb; ib += 2) {
+        const block_mxfp4 * GGML_RESTRICT x0 = &x[ib + 0];
+        const block_mxfp4 * GGML_RESTRICT x1 = &x[ib + 1];
+        const block_q8_0  * GGML_RESTRICT y0 = &y[ib + 0];
+        const block_q8_0  * GGML_RESTRICT y1 = &y[ib + 1];
+
+        const uint8x16_t v_x0 = vec_xl(0, x0->qs);
+        const uint8x16_t v_x1 = vec_xl(0, x1->qs);
+
+        int8x16_t v_x0l = (int8x16_t)vec_and(v_x0, v_m);
+        int8x16_t v_x0h = (int8x16_t)vec_sr(v_x0, 4);
+        int8x16_t v_x1l = (int8x16_t)vec_and(v_x1, v_m);
+        int8x16_t v_x1h = (int8x16_t)vec_sr(v_x1, 4);
+
+        v_x0l = vec_perm(v_k, v_k, (uchar8x16_t)v_x0l);
+        v_x0h = vec_perm(v_k, v_k, (uchar8x16_t)v_x0h);
+        v_x1l = vec_perm(v_k, v_k, (uchar8x16_t)v_x1l);
+        v_x1h = vec_perm(v_k, v_k, (uchar8x16_t)v_x1h);
+
+        const int8x16_t v_y0l = vec_xl(0,       y0->qs);
+        const int8x16_t v_y0h = vec_xl(QK8_0/2, y0->qs);
+        const int8x16_t v_y1l = vec_xl(0,       y1->qs);
+        const int8x16_t v_y1h = vec_xl(QK8_0/2, y1->qs);
+
+        const int32x4_t v_xy0 = ggml_vec_dot(ggml_vec_dot(vec_splats(0), v_x0l, v_y0l), v_x0h, v_y0h);
+        const int32x4_t v_xy1 = ggml_vec_dot(ggml_vec_dot(vec_splats(0), v_x1l, v_y1l), v_x1h, v_y1h);
+
+        const float32x4_t v_xy0f = vec_float(v_xy0);
+        const float32x4_t v_xy1f = vec_float(v_xy1);
+
+        const float32x4_t v_d0 = vec_splats(GGML_E8M0_TO_FP32_HALF(x0->e) * GGML_CPU_FP16_TO_FP32(y0->d));
+        const float32x4_t v_d1 = vec_splats(GGML_E8M0_TO_FP32_HALF(x1->e) * GGML_CPU_FP16_TO_FP32(y1->d));
+
+        v_acc = vec_madd(v_xy0f, v_d0, v_acc);
+        v_acc = vec_madd(v_xy1f, v_d1, v_acc);
+    }
+
+    for (; ib < nb; ++ib) {
+        const block_mxfp4 * GGML_RESTRICT x0 = &x[ib + 0];
+        const block_q8_0  * GGML_RESTRICT y0 = &y[ib + 0];
+
+        const uint8x16_t v_x = vec_xl(0, x0->qs);
+
+        int8x16_t v_xl = (int8x16_t)vec_and(v_x, v_m);
+        int8x16_t v_xh = (int8x16_t)vec_sr(v_x, 4);
+
+        v_xl = vec_perm(v_k, v_k, (uchar8x16_t)v_xl);
+        v_xh = vec_perm(v_k, v_k, (uchar8x16_t)v_xh);
+
+        const int8x16_t v_yl = vec_xl(0,       y0->qs);
+        const int8x16_t v_yh = vec_xl(QK8_0/2, y0->qs);
+
+        const int32x4_t v_xy = ggml_vec_dot(ggml_vec_dot(vec_splats(0), v_xl, v_yl), v_xh, v_yh);
+        const float32x4_t v_xyf = vec_float(v_xy);
+
+        const float32x4_t v_d = vec_splats(GGML_E8M0_TO_FP32_HALF(x0->e) * GGML_CPU_FP16_TO_FP32(y0->d));
+        v_acc = vec_madd(v_xyf, v_d, v_acc);
+    }
+
+    sumf = vec_hsum_f32x4(v_acc);
+    *s = sumf;
+#else
+    UNUSED(x);
+    UNUSED(y);
+    UNUSED(ib);
+    UNUSED(sumf);
+    ggml_vec_dot_mxfp4_q8_0_generic(n, s, bs, vx, bx, vy, by, nrc);
+#endif
+}
+
 void ggml_vec_dot_q5_0_q8_0(int n, float * GGML_RESTRICT s, size_t bs, const void * GGML_RESTRICT vx, size_t bx, const void * GGML_RESTRICT vy, size_t by, int nrc) {
     const int qk = QK8_0;
     const int nb = n / qk;