If the DOTNET_SYSTEM_GLOBALIZATION_INVARIANT environment variable is set to either true or 1, the plugin will crash upon initialization. For me at least, the variable was set to 1 by default in my user session, but only in some cases (i.e. using Flatpak Lutris, it was set to 1, but using native Lutris, it was not).
You can apparently change this behavior via the project's build configuration as well, as described by the docs.
I suppose it would be safe to change this to false, but I have no idea whether or not it could introduce other problems, I just lack C#/.NET knowledge.