diff --git a/godot-bindings/src/import.rs b/godot-bindings/src/import.rs
index 5b69f8fda..86940484a 100644
--- a/godot-bindings/src/import.rs
+++ b/godot-bindings/src/import.rs
@@ -63,3 +63,96 @@ pub use gdextension_api::version_4_5 as prebuilt;
 //  [line] pub use gdextension_api::version_$snakeVersion as prebuilt;
 pub use gdextension_api::version_4_5 as prebuilt;
 // ]]
+
+// Platform-specific header loading for cross-compilation support.
+// The prebuilt module is compiled for HOST (not TARGET) when used as a build-dependency,
+// so we determine the platform at runtime based on CARGO_CFG_TARGET_* environment variables.
+#[cfg(not(any(feature = "api-custom", feature = "api-custom-json")))]
+pub(crate) mod prebuilt_platform {
+    use std::borrow::Cow;
+
+    /// Load platform-specific prebuilt bindings based on the TARGET platform (not HOST).
+    ///
+    /// Since godot-bindings is a build-dependency, it's compiled for HOST, but we need bindings for TARGET.
+    /// We detect the target platform using CARGO_CFG_TARGET_* environment variables available during
+    /// build script execution, then read the corresponding file from the gdextension-api dependency.
+    pub fn load_gdextension_header_rs_for_target() -> Cow<'static, str> {
+        // Determine TARGET platform from environment variables
+        let target_family = std::env::var("CARGO_CFG_TARGET_FAMILY").ok();
+        let target_os = std::env::var("CARGO_CFG_TARGET_OS").ok();
+
+        // Select platform suffix matching gdextension-api's file naming
+        let platform = match (target_family.as_deref(), target_os.as_deref()) {
+            (Some("windows"), _) => "windows",
+            (_, Some("macos" | "ios")) => "macos",
+            _ => "linux", // Linux, Android, and other Unix-like systems
+        };
+
+        // Read the file from gdextension-api dependency in Cargo cache
+        load_platform_file_from_cache(platform)
+    }
+
+    /// Load platform-specific bindings file from the gdextension-api dependency.
+    fn load_platform_file_from_cache(platform: &str) -> Cow<'static, str> {
+        let home = std::env::var("HOME")
+            .or_else(|_| std::env::var("USERPROFILE"))
+            .expect("HOME or USERPROFILE environment variable");
+
+        // Search git checkouts (for git dependencies)
+        if let Some(contents) = try_load_from_git(&home, platform) {
+            return Cow::Owned(contents);
+        }
+
+        // Search registry (for crates.io dependencies)
+        if let Some(contents) = try_load_from_registry(&home, platform) {
+            return Cow::Owned(contents);
+        }
+
+        panic!(
+            "Failed to locate gdextension-api dependency for platform '{}'.\n\
+             The dependency should be in Cargo cache at:\n\
+             - {}/.cargo/git/checkouts/godot4-prebuilt-*\n\
+             - {}/.cargo/registry/src/*/gdextension-api-*",
+            platform, home, home
+        );
+    }
+
+    fn try_load_from_git(home: &str, platform: &str) -> Option<String> {
+        let git_dir = format!("{home}/.cargo/git/checkouts");
+        for entry in std::fs::read_dir(&git_dir).ok()?.flatten() {
+            let path = entry.path();
+            if path.file_name()?.to_str()?.starts_with("godot4-prebuilt-") {
+                // Found godot4-prebuilt checkout, look for the hash subdirectory
+                for subdir in std::fs::read_dir(&path).ok()?.flatten() {
+                    let file_path = subdir.path().join(format!(
+                        "versions/4.5/res/gdextension_interface_{}.rs",
+                        platform
+                    ));
+                    if let Ok(contents) = std::fs::read_to_string(&file_path) {
+                        return Some(contents);
+                    }
+                }
+            }
+        }
+        None
+    }
+
+    fn try_load_from_registry(home: &str, platform: &str) -> Option<String> {
+        let registry_dir = format!("{home}/.cargo/registry/src");
+        for host_entry in std::fs::read_dir(&registry_dir).ok()?.flatten() {
+            for crate_entry in std::fs::read_dir(host_entry.path()).ok()?.flatten() {
+                let path = crate_entry.path();
+                if path.file_name()?.to_str()?.starts_with("gdextension-api-") {
+                    let file_path = path.join(format!(
+                        "versions/4.5/res/gdextension_interface_{}.rs",
+                        platform
+                    ));
+                    if let Ok(contents) = std::fs::read_to_string(&file_path) {
+                        return Some(contents);
+                    }
+                }
+            }
+        }
+        None
+    }
+}
diff --git a/godot-bindings/src/lib.rs b/godot-bindings/src/lib.rs
index 5e3346010..7d4464646 100644
--- a/godot-bindings/src/lib.rs
+++ b/godot-bindings/src/lib.rs
@@ -129,7 +129,11 @@ mod depend_on_prebuilt {
             .unwrap_or_else(|e| panic!("failed to write gdextension_interface.h: {e}"));
         watch.record("write_header_h");
 
-        let rs_contents = prebuilt::load_gdextension_header_rs();
+        // CROSS-COMPILATION FIX:
+        // Since godot-bindings is a build-dependency, it and gdextension-api are compiled for the HOST platform.
+        // The #[cfg] attributes in gdextension-api::load_gdextension_header_rs() evaluate for HOST, not TARGET.
+        // We read CARGO_CFG_TARGET_* environment variables to select the correct bindings at runtime.
+        let rs_contents = crate::import::prebuilt_platform::load_gdextension_header_rs_for_target();
         std::fs::write(rs_path, rs_contents.as_ref())
             .unwrap_or_else(|e| panic!("failed to write gdextension_interface.rs: {e}"));
         watch.record("write_header_rs");