diff --git a/google-cloud-spanner/src/main/java/com/google/cloud/spanner/SessionImpl.java b/google-cloud-spanner/src/main/java/com/google/cloud/spanner/SessionImpl.java
index bce8a8d375..68c37561c9 100644
--- a/google-cloud-spanner/src/main/java/com/google/cloud/spanner/SessionImpl.java
+++ b/google-cloud-spanner/src/main/java/com/google/cloud/spanner/SessionImpl.java
@@ -468,12 +468,18 @@ public AsyncTransactionManagerImpl transactionManagerAsync(TransactionOption...
 
   @Override
   public ApiFuture<Empty> asyncClose() {
+    if (getIsMultiplexed()) {
+      return com.google.api.core.ApiFutures.immediateFuture(Empty.getDefaultInstance());
+    }
     XGoogSpannerRequestId reqId = this.getRequestIdCreator().nextRequestId(this.getChannel(), 1);
     return spanner.getRpc().asyncDeleteSession(getName(), reqId.withOptions(getOptions()));
   }
 
   @Override
   public void close() {
+    if (getIsMultiplexed()) {
+      return;
+    }
     ISpan span = tracer.spanBuilder(SpannerImpl.DELETE_SESSION);
     try (IScope s = tracer.withSpan(span)) {
       XGoogSpannerRequestId reqId = this.getRequestIdCreator().nextRequestId(this.getChannel(), 1);
diff --git a/google-cloud-spanner/src/test/java/com/google/cloud/spanner/DatabaseClientImplTest.java b/google-cloud-spanner/src/test/java/com/google/cloud/spanner/DatabaseClientImplTest.java
index fa8b5c982f..fa95c55183 100644
--- a/google-cloud-spanner/src/test/java/com/google/cloud/spanner/DatabaseClientImplTest.java
+++ b/google-cloud-spanner/src/test/java/com/google/cloud/spanner/DatabaseClientImplTest.java
@@ -3601,9 +3601,16 @@ public void testBackendPartitionQueryOptions() {
       // statistics package and directed read options.
       List<AbstractMessage> requests = mockSpanner.getRequests();
       assert requests.size() >= 2 : "required to have at least 2 requests";
-      assertThat(requests.get(requests.size() - 1)).isInstanceOf(DeleteSessionRequest.class);
-      assertThat(requests.get(requests.size() - 2)).isInstanceOf(ExecuteSqlRequest.class);
-      ExecuteSqlRequest executeSqlRequest = (ExecuteSqlRequest) requests.get(requests.size() - 2);
+      if (isMultiplexedSessionsEnabled()) {
+        assertThat(requests.get(requests.size() - 1)).isInstanceOf(ExecuteSqlRequest.class);
+      } else {
+        assertThat(requests.get(requests.size() - 1)).isInstanceOf(DeleteSessionRequest.class);
+        assertThat(requests.get(requests.size() - 2)).isInstanceOf(ExecuteSqlRequest.class);
+      }
+      ExecuteSqlRequest executeSqlRequest =
+          (ExecuteSqlRequest)
+              requests.get(
+                  isMultiplexedSessionsEnabled() ? requests.size() - 1 : requests.size() - 2);
       assertThat(executeSqlRequest.getQueryOptions()).isNotNull();
       assertThat(executeSqlRequest.getQueryOptions().getOptimizerVersion()).isEqualTo("1");
       assertThat(executeSqlRequest.getQueryOptions().getOptimizerStatisticsPackage())
@@ -3651,9 +3658,16 @@ public void testBackendPartitionQueryOptions() {
       // statistics package and directed read options.
       List<AbstractMessage> requests = mockSpanner.getRequests();
       assert requests.size() >= 2 : "required to have at least 2 requests";
-      assertThat(requests.get(requests.size() - 1)).isInstanceOf(DeleteSessionRequest.class);
-      assertThat(requests.get(requests.size() - 2)).isInstanceOf(ExecuteSqlRequest.class);
-      ExecuteSqlRequest executeSqlRequest = (ExecuteSqlRequest) requests.get(requests.size() - 2);
+      if (isMultiplexedSessionsEnabled()) {
+        assertThat(requests.get(requests.size() - 1)).isInstanceOf(ExecuteSqlRequest.class);
+      } else {
+        assertThat(requests.get(requests.size() - 1)).isInstanceOf(DeleteSessionRequest.class);
+        assertThat(requests.get(requests.size() - 2)).isInstanceOf(ExecuteSqlRequest.class);
+      }
+      ExecuteSqlRequest executeSqlRequest =
+          (ExecuteSqlRequest)
+              requests.get(
+                  isMultiplexedSessionsEnabled() ? requests.size() - 1 : requests.size() - 2);
       assertThat(executeSqlRequest.getQueryOptions()).isNotNull();
       assertThat(executeSqlRequest.getQueryOptions().getOptimizerVersion()).isEqualTo("1");
       assertThat(executeSqlRequest.getQueryOptions().getOptimizerStatisticsPackage())
@@ -3697,9 +3711,16 @@ public void testBackendPartitionReadOptions() {
       // statistics package and directed read options.
       List<AbstractMessage> requests = mockSpanner.getRequests();
       assert requests.size() >= 2 : "required to have at least 2 requests";
-      assertThat(requests.get(requests.size() - 1)).isInstanceOf(DeleteSessionRequest.class);
-      assertThat(requests.get(requests.size() - 2)).isInstanceOf(ReadRequest.class);
-      ReadRequest readRequest = (ReadRequest) requests.get(requests.size() - 2);
+      if (isMultiplexedSessionsEnabled()) {
+        assertThat(requests.get(requests.size() - 1)).isInstanceOf(ReadRequest.class);
+      } else {
+        assertThat(requests.get(requests.size() - 1)).isInstanceOf(DeleteSessionRequest.class);
+        assertThat(requests.get(requests.size() - 2)).isInstanceOf(ReadRequest.class);
+      }
+      ReadRequest readRequest =
+          (ReadRequest)
+              requests.get(
+                  isMultiplexedSessionsEnabled() ? requests.size() - 1 : requests.size() - 2);
       assertThat(readRequest.getDirectedReadOptions()).isEqualTo(DIRECTED_READ_OPTIONS1);
     }
   }
@@ -3740,9 +3761,16 @@ public void testBackendPartitionReadOptions() {
       // statistics package and directed read options.
       List<AbstractMessage> requests = mockSpanner.getRequests();
       assert requests.size() >= 2 : "required to have at least 2 requests";
-      assertThat(requests.get(requests.size() - 1)).isInstanceOf(DeleteSessionRequest.class);
-      assertThat(requests.get(requests.size() - 2)).isInstanceOf(ReadRequest.class);
-      ReadRequest readRequest = (ReadRequest) requests.get(requests.size() - 2);
+      if (isMultiplexedSessionsEnabled()) {
+        assertThat(requests.get(requests.size() - 1)).isInstanceOf(ReadRequest.class);
+      } else {
+        assertThat(requests.get(requests.size() - 1)).isInstanceOf(DeleteSessionRequest.class);
+        assertThat(requests.get(requests.size() - 2)).isInstanceOf(ReadRequest.class);
+      }
+      ReadRequest readRequest =
+          (ReadRequest)
+              requests.get(
+                  isMultiplexedSessionsEnabled() ? requests.size() - 1 : requests.size() - 2);
       assertThat(readRequest.getDirectedReadOptions()).isEqualTo(DIRECTED_READ_OPTIONS2);
     }
   }