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06-knowledgebases.Rmd

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### Foundation One
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Foundation One provides tests for solid tumor as well as a liquid tumors. These tests take a tissue sample or a blood draw and search a panel of 300+ genes for cancer-relevant mutations. The tests are FDA-approved for discovery of relevant variants for targeted therapy, immunotherapy, or clinical trial options for the patient. An internal knowledgebase is curated and maintained in order to provide variant intepretations along with generated reports.
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Foundation One provides tests for solid tumor as well as a liquid tumors. These tests take a tissue sample or a blood draw and search a panel of 300+ genes for cancer-relevant mutations. The tests are FDA-approved for discovery of relevant variants for targeted therapy, immunotherapy, or clinical trial options for the patient. An internal knowledgebase is curated and maintained in order to provide variant interpretations along with generated reports.

07-civic_overview.Rmd

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## Introduction to the CIViC web interface
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The CIViC web interface provides an interactive portal for browsing and searching exising cancer variants, evidence and assertions. It also provides a sophisticated curation interface for submitting new evidence or assertions, revisions to exising content, or comments. A brief tour of the [CIViC v2](https://civicdb.org){target="_blank"} interface is available here:
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The CIViC web interface provides an interactive portal for browsing and searching existing cancer variants, evidence and assertions. It also provides a sophisticated curation interface for submitting new evidence or assertions, revisions to exising content, or comments. A brief tour of the [CIViC v2](https://civicdb.org){target="_blank"} interface is available here:
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```{r, echo=FALSE}
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knitr::include_url("https://www.youtube.com/embed/bpVkSP7qvgc")

resources/dictionary.txt

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1+
AACR
2+
ABL
3+
ACMG
4+
actionability
5+
actionablilty
6+
afatinib
7+
AKT
8+
al
9+
Albracht
10+
allelic
11+
allignment
12+
amorphic
113
AnVIL
214
ASCO
15+
BAC
16+
Barnell
17+
BCR
18+
bioinformatics
19+
biomarker
320
BIPOC
421
Bloomberg
522
Bookdown
23+
Bouk
24+
bp
25+
Catalogue
26+
CCG
627
CGC
728
CIViC
829
civicdb
930
ClinGen
1031
ClinVar
32+
CML
33+
CNLOH
34+
CNVs
35+
Coffman
36+
colorectal
37+
counterindication
1138
Coursera
1239
css
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curation
14-
Datatrail
41+
Danos
1542
DataTrail
43+
Datatrail
44+
de
45+
disregulated
1646
Dockerfile
1747
Dockerhub
1848
dropdown
49+
duplications
50+
EGFR
51+
erlotinib
52+
ESMO
53+
et
1954
favicon
55+
FFPE
56+
FGFR
57+
frameshift
2058
fyi
2159
GDSCN
2260
GenBank
61+
germline
62+
GH
2363
GitHub
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Github
25-
GH
2665
gnomAD
27-
impactful
28-
ITCR
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itcrtraining
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ITN
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knowledgebases
32-
knowledgebase
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Leanpub
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rmarkdown
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Markua
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mentorship
37-
NCI
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NHGRI
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oncogenicity
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oncoKB
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OncoKB
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ottrpal
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Pandoc
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pathogenicity
45-
UE
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UE5
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RefSeq
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reproducibility
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SOPs
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SOP
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underserved
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VICC
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www
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ACMG
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AKT
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Albracht
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BAC
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Barnell
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Bouk
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Coffman
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Danos
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EGFR
63-
FFPE
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GRC
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GRCh
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Grisdale
67-
HGVS
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Hanahan
69-
Hypomorphic
70-
Hypermorphic
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IGV
72-
KRAS
73-
Kitts
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Kiwala
75-
Krysiak
76-
Kujan
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LOF
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McMichael
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NGS
80-
Neomorphic
81-
Nissen
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Oncogenic
83-
Pema
84-
Ph
85-
PubMed
86-
Raca
87-
Rao
88-
Ritter
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SBS
90-
Sheta
91-
Sonkin
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Thibaud
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Wollam
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actionability
95-
al
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allelic
97-
bp
98-
colorectal
99-
counterindication
100-
de
101-
et
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germline
70+
heterozygosity
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hg
104-
hypomorphic
105-
kb
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kilobase
107-
kinases
108-
novo
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nucleotides
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oncogenic
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phenotypes
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segmentally
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siloed
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subtypes
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tyrosine
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vitro
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word
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ACMG
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AKT
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Albracht
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BAC
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Barnell
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Bouk
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Coffman
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Danos
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EGFR
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FFPE
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GRC
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GRCh
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Grisdale
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HGVS
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Hanahan
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Hyopmorphic
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Hypermorphic
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Hypomorphic
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hypomorphic
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ICGC
13578
IGV
136-
KRAS
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imatinib
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immunotherapy
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impactful
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Indels
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indels
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independant
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ITCR
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itcrtraining
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ITN
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kb
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kilobase
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kinases
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Kitts
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Kiwala
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KMS
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knowledgebase
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knowledgebases
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KRAS
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Krysiak
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Kujan
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Leanpub
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LOF
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Markua
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McMichael
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NGS
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mentorship
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Missense
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missense
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MSK
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MyCancerGenome
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myeloid
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NCI
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Neomorphic
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NGS
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NHGRI
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Nissen
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novo
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NTRK
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nucleotides
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Oncogenic
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oncogenic
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oncogenicity
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OncoKB
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oncoKB
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OnkoKB
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ottrpal
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Pandoc
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Parimony
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pathogenicity
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Pema
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Ph
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phenotypes
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preclinical
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Proline
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PubMed
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Raca
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Rao
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RefSeq
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reproducibility
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Ritter
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rmarkdown
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SBS
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Sheta
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Sonkin
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Thibaud
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Wollam
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actionability
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al
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allelic
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bp
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colorectal
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counterindication
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de
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et
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germline
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hg
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hypomorphic
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independant
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kb
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kilobase
172-
kinases
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novo
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nucleotides
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oncogenic
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phenotypes
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segmentally
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Sheta
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siloed
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subtypes
180-
theeffect
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tyrosine
182-
vitro
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word
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AACR
185-
ABL
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BCR
187-
CCG
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CML
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CNLOH
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CNVs
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Catalogue
192-
ESMO
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FGFR
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ICGC
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Indels
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KMS
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MSK
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Missense
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NTRK
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OnkoKB
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Parimony
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Proline
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SNVs
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Sonkin
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SOP
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SOPs
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Submitters
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submitters
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subtypes
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targetable
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TCGA
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tetramer
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TGA
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TGC
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th
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theeffect
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Thibaud
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tiering
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Translocations
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tyrosine
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UE
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UE5
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underserved
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VCEP
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VCEPs
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VCF
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VICC
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vitro
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VUS
213-
actionablilty
214-
afatinib
215-
allignment
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amorphic
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bioinformatics
218-
biomarker
219-
disregulated
220-
duplications
221-
erlotinib
222-
frameshift
223-
imatinib
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immunotherapy
225-
indels
226-
missense
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myeloid
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preclinical
229-
submitters
230-
targetable
231-
tetramer
232-
th
233-
tiering
170+
Wollam
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word
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www

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