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add link to anitbody-antigen Sofia video
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education/HADDOCK3/HADDOCK3-antibody-antigen/index.md

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layout: page
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title: "Antibody-antigen modelling tutorial using a local version of HADDOCK3"
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title: "Antibody-antigen modelling tutorial using a local version of HADDOCK3 w3griugiwuefg"
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excerpt: "A tutorial describing the use of HADDOCK3 in the low-sampling scenario to model an antibody-antigen complex"
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tags: [HADDOCK, HADDOCK3, installation, preparation, proteins, docking, analysis, workflows, sampling]
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image:
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the structure of an antibody-antigen complex using knowledge of the hypervariable loops
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on the antibody (i.e., the most basic knowledge) and epitope information identified from NMR experiments for the antigen to guide the docking.
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**Video-recording of this tutorial, captured at BioExcel Sofia May 2025 Workshop, is available [here](https://youtu.be/0pLOPev3ni0?feature=shared){:target="_blank"}.**
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An antibody is a large protein that generally works by attaching itself to an antigen,
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which is a unique site of the pathogen. The binding harnesses the immune system to directly
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attack and destroy the pathogen. Antibodies can be highly specific while showing low immunogenicity (i.e. the ability to provoke an immune response),

education/HADDOCK3/index.md

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* [**Basic docking run with HADDOCK3**](/education/HADDOCK3/HADDOCK3-antibody-antigen):
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This tutorial describes a full step-by-step process from preparing the files for the docking, to the interpretation of the results. It is a good idea to go through it to get a basic introduction to HADDOCK3. *Note that this is the basic antibody-antigen tutorial; if you've already followed it elsewhere, there's no need to repeat it.*
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This tutorial describes a full step-by-step process from preparing the files for the docking, to the interpretation of the results. Video-recording of this tutorial is available [here](https://youtu.be/0pLOPev3ni0?feature=shared){:target="_blank"}. It is a good idea to go through it to get a basic introduction to HADDOCK3. *Note that this is the basic antibody-antigen tutorial; if you've already followed it elsewhere, there's no need to repeat it.*
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