Added links

Author: amjjbonvin

news/_posts/2025-03-11-MERUS-bifunctional-antibody-approved.md

@@ -20,7 +20,7 @@ The approved therapeutic, and many others in Merus’ pipeline, is based on thei
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-DEKK refers to four charged substitutions (D:Asp, E:Glu, K:Lys) that were introduced into the Fc domains of the antibody. The HADDOCK software, developed in the Bonvin group at Utrecht Univerisity, was originally used, more than 10 years ago, to design and test those substitutions. HADDOCK was used in its refinement mode, to obtain the HADDOCK scores of the various combinations. This led to a number of candidates that favored the asymmetric assemblies of the heavy chains over the symmetric ones. These were extensively characterized by a battery of biochemical and biophysical methods (including extensive mass spectrometry studies by the [Albert Heck's group](https://www.uu.nl/staff/AJRHeck){:target="_blank"} in Utrecht) leading ultimately to the patented DEKK version. The general approach and the crystal structure of the DEKK antibody Fc domains was published in 2017 in the Journal of Biological Chemistry (De Nardis et al. 2017) (PDB entry [5NSC](https://www.ebi.ac.uk/pdbe/entry/pdb/5nsc){:target="_blank"}) (a collaboration with [Piet Gros' group](https://www.uu.nl/staff/PGros){:target="_blank"} in Utrecht).
+DEKK refers to four charged substitutions (D:Asp, E:Glu, K:Lys) that were introduced into the Fc domains of the antibody. The [HADDOCK software](https://bonvinlab.org/software){:target="_blank"}, developed in the Bonvin group at Utrecht Univerisity, was originally used, more than 10 years ago, to design and test those substitutions. HADDOCK was used in its refinement mode, to obtain the HADDOCK scores of the various combinations. This led to a number of candidates that favored the asymmetric assemblies of the heavy chains over the symmetric ones. These were extensively characterized by a battery of biochemical and biophysical methods (including extensive mass spectrometry studies by the [Albert Heck's group](https://www.uu.nl/staff/AJRHeck){:target="_blank"} in Utrecht) leading ultimately to the patented DEKK version. The general approach and the crystal structure of the DEKK antibody Fc domains was published in 2017 in the Journal of Biological Chemistry (De Nardis et al. 2017) (PDB entry [5NSC](https://www.ebi.ac.uk/pdbe/entry/pdb/5nsc){:target="_blank"}) (a collaboration with [Piet Gros' group](https://www.uu.nl/staff/PGros){:target="_blank"} in Utrecht).
 
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@@ -31,7 +31,7 @@ DEKK refers to four charged substitutions (D:Asp, E:Glu, K:Lys) that were introd
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-This nicely illustrates the long term impact that molecular modelling software like HADDOCK can have. HADDOCK is a core software in the EuroHPC BioExcel Center of Excellence for Computational Biomolecular Research (bioexcel.eu)
+This nicely illustrates the long term impact that molecular modelling software like HADDOCK can have. HADDOCK is a core software in the [EuroHPC](https://eurohpc-ju.europa.eu/index_en){:target="_blank"} [BioExcel Center of Excellence for Computational Biomolecular Research](https://bioexcel.eu){:target="_blank"}.
 
 * C. De Nardis,LJ.A. Hendriks,E. Poirier, T. Arvinte, P. Gros, A.B.H. Bakker, J. de Kruif. [A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1](https://www.jbc.org/article/S0021-9258(20)34207-1/fulltext){:target="_blank"}.  _J. Biol. Chem._ *292*, 14706-14717 (2017).