GenFORM: from Free Text to Operational Knowledge Rules

GenFORM: from Free Text to Operational Knowledge Rules

Core Definitions

Term	Definition
GenFORM	A generic formulary system that transforms free-text medication knowledge into fully computable Operational Knowledge Rules (OKRs).
Operational Knowledge Rule (OKR)	A fully structured, machine-interpretable and constraint-based representation of medication knowledge used for prescribing, preparation, and administration.
Dose Rule	An OKR that defines qualitative and quantitative constraints for dosing a specific generic in a defined clinical context.
Dose Limit	A set of numeric constraints defining the minimum, maximum, or normative allowable dose.
Dose	A patient-specific calculated dose value that satisfies all applicable constraints. Note that a dose can be per administration, per time unit, or rate unit and can be adjusted for patient weight or BSA.
Dose Type	The temporal category of dosing (e.g., once, timed, continuous).
Selection Constraint	A rule element used to determine which calculation constraints apply.
Calculation Constraint	A quantitative rule element used to compute dose, rate, volume, or timing.
Adjustment Unit	A patient normalization unit used to scale doses (e.g., kg for weight, m² for BSA).
Relative Adjustment	A renal or clinical adjustment expressed as a multiplier of the base dose.
Absolute Adjustment	A renal or clinical adjustment expressed as an absolute numeric replacement of a dose.
Reconstitution	The process of converting a medication into an administrable form by adding a diluent.
Expansion Volume	The increase in total volume resulting from reconstitution.
Solution	The process of further adjusting concentration and volume for safe administration.
Administration Fraction	The fraction of the prepared solution used to deliver the calculated dose.
Generic Product (GPK)	An abstract pharmaceutical product definition independent of branding.
Prescription Product (PRK)	A prescribable form of a generic product.
Trade Product (HPK)	A branded pharmaceutical product.
Consumer Product (ZInr)	A retail package variant of a trade product.

1. Objectives

The aim of GenFORM is to extract and structure expert medication-related knowledge, together with all additional operational information, so that medication can be automatically prescribed, planned, prepared, and administered (see Addendum A. The Medication Treatment Cycle).

GenFORM (Generic FORMulary) is a generic solution that produces Operational Knowledge Rules (OKRs): fully computable, constraint-based representations of all medication knowledge relevant to prescribing, preparing, and administering medication.

To create OKRs, free text or semi-structured clinical texts are transformed into a fully structured and machine-interpretable format. The resulting OKRs define explicit constraints on indications, dosing, scheduling, preparation, administration, product availability, and patient-specific parameters.

Because OKRs are expressed as constraints, they can be used by a constraint-solving engine to compute all valid options for a given clinical context. The user selects the most appropriate option, and this selection acts as an additional constraint that further narrows the solution space. Consequently, every option presented—and every option chosen—remains, by definition, within the boundaries defined by the OKRs and is therefore guaranteed to be valid.

2. Operational Knowledge Rules

OKRs should allow for:

Selecting the specific scenario determined by:
1. The indication and
2. The medication (generic naming) and
3. The route of administration and/or
4. The pharmaceutical form and
5. The type of dosing

In addition, the following context information for a specific patient and clinical situation is required:

The setting: location/department and
The patient: gender, and min/max ranges for age, weight, body surface area (BSA), gestational age, and post-menstrual age.

Together, all of the above rule items form a constraint qualifying system that determines which actual quantitative dose rule settings are applicable. These quantitative settings are:

The specific available medication product assortment that can be used
Dose schedule settings and
Dose limit settings

The dose schedule settings contain all quantitative constraints to allow calculation of the dose scheduling, the dose limit settings contain the quantitative constraints to allow calculation of the actual dose.

Finally, dose adjustment rules like renal rules can apply that are used to adjust schedule and/or dose limit settings.

3. Sources and Types of Dose Rules

Currently, dose rules are defined across multiple source documents and repositories. These rules can be categorized into two primary types:

Dose checking rules: Rules that verify whether a prescribed dose falls within acceptable margins, primarily ensuring that no over- or underdosing occurs.
Dose advice rules: Rules that specify recommended exact dose(s) within the boundaries set by the checking rules or that enable calculation of exact dose(s).

Dose checking rules are maintained in the national registry, the G-Standaard. More specific dose advice rules are available in several additional sources:

Farmacotherapeutisch Kompas: contains dose advice rules for adults and part of the pediatric population.
Kinderformularium: contains all pediatric dose advice rules.
SWAB (Stichting Werkgroep Antibiotica Beleid) guidelines: contain antibiotic-specific dose advice rules.
Oncology protocols: contain dose advice rules for oncology medications.
Local protocols: contain hospital- or specialty-specific dose advice rules.

4. Additional Information

To establish a structured and operational knowledge-rule system that supports prescribing, planning, preparation, and administration, additional information is required:

Reconstitution rules: define how medication must be reconstituted to enable administration of, for example, a powder as a liquid.
Solution rules: define requirements for the amount and/or concentration of liquid medication.
Renal rules: used to adjust the dose advice according to the renal function (GFR normal, too low or too high).
Product information: defines product availability, pharmaceutical forms, and parameters required for calculating the delivered dose.

Reconstitution and solution rules are typically summarized in parenteralia, while the corresponding information for oral medication is provided in oralia.

For renal rules specific sections are available in the Kinderformularium or specific renal reference guidelines.

All required product information can be obtained from the G-Standaard.

5. Operational Structure of a Dose Rule

In order to be available as an OKR, the dose rule needs to be structured so that:

The context can be specified so it can be narrowed down to specifically one dose rule.
The resulting dose rule needs to contain all information necessary to perform a full calculation of prescription, preparation and administration of a medication.
Every possible dosing scenario should be able to be encoded as an operational dose rule structure.

This results in the dose rule structure as shown in Appendix D. The Dose Rule Structure.

6. Selection and Calculation Constraints

All OKRs can be translated to either selection or calculation constraints. The selection constraints determine which calculation constraints are available. For every set of calculation constraints there is exactly one set of selection constraints that uniquely identifies the calculation constraints (i.e. the dose).

6.1. Selection Constraints

Dose Rule
- Source
- Generic
- Indication
- Route
- Setting
- Patient
- Dose Type
- Component
- Substance
Reconstitution Rule
- Generic
- GPK
- Form
- Route
- Setting
Solution Rule
- Generic
- Form
- Route
- Indication
- Dose Type
- Setting
- Administration Access Device (e.g., CVL/PVL)
- Patient
- Dose
- Substance
Renal Rule
- Source
- Generic
- Indication
- Patient
- Renal Function

6.2. Calculation Constraints

Dose Rule
- Schedule
- Duration
- Dose Limits
Reconstitution Rule:
- Diluent Volume
- Expansion Volume
Solution Rule:
- Volume
- Drip Rate
- Administration Fraction
- Dose
- Concentration
Renal Rule
- Schedule
- Dose Adjustment (relative or absolute)

7. Prescription Rules

Dose-, Reconstitution-, Solution- and Renal rules are combined within a patient context and specific setting into a Prescription Rule. The Prescription Rule can, therefore, be used to generate an order determining, prescription, preparation and administration of an order.

8. Related Documents

GenFORM is part of the GenPRES transformation pipeline. The following documents provide additional context:

Document	Description	Relationship
Core Domain Model	Central domain definitions and transformation pipeline	GenFORM is the Layer 1 component transforming free text to OKRs
GenORDER	Transforms OKRs to Order Scenarios	Consumes OKRs produced by GenFORM
GenSOLVER	Constraint solving engine	Provides algorithmic foundation used by GenORDER

8.1. Pipeline Position

Free Text → [GenFORM] → OKRs → [GenORDER] → Order Scenarios → [GenSOLVER] → Quantitative Solutions

GenFORM occupies the first transformation stage, responsible for:

Parsing free-text and semi-structured clinical texts
Extracting Selection Constraints and Calculation Constraints
Producing fully computable Operational Knowledge Rules (OKRs)

8.2. Patient Category vs Patient

GenFORM defines Patient Categories (also referred to as "Patient" in rule tables)—these are types of patients characterized by demographic ranges (age, weight, BSA, gestational age). A Patient Category is not a specific individual but rather a classification used to determine which rules apply.

In contrast, GenORDER works with a specific Patient instance—an actual individual with concrete demographic values. GenORDER matches the Patient's attributes against GenFORM's Patient Categories to select the applicable OKRs.

For a specific patient, a matching property like BSA can be calculated from weight and height (e.g., Mosteller: $\mathrm{BSA}(m^2)=\sqrt{(\mathrm{height}{cm}\cdot\mathrm{weight}{kg})/3600}$).

8.3. Key Terminology Alignment

GenFORM Term	Related Term in Other Documents	Notes
Operational Knowledge Rule (OKR)	Rule (Core Domain)	Umbrella term for all computable rules
Dose Rule	Dose Rule (GenORDER)	Applied to specific patient context in GenORDER
Solution Rule	Solution Rule (GenORDER)	Formerly "DilutionRule" in some contexts
Patient (in rule tables)	Patient Category (GenORDER)	GenFORM defines categories; GenORDER matches patients
Selection Constraint	Filter Stage (GenORDER)	Determines rule applicability
Calculation Constraint	Solver Stage (GenORDER)	Provides quantitative bounds

Appendices

The below appendices provide graphical and table detailed representations of all rule related concepts.

In tables, mutually exclusive options are represented by a bar "|".

Appendix A. The Medication Treatment Cycle

Appendix B.1. GenFORM Conceptual Architecture

Free text is structured by GenFORM to operational structured knowledge rules and can be returned as human-readable text.

Appendix B.2. GenFORM Technical Architecture

Addendum B.3. GenFORM Libraries

Classification:

Free Text Sources
Utility Library
Domain Library

Libraries:

Informedica.Agents.Lib: Library using the FSharp MailboxProcessor to create message based agents.
- Capabilities:
  - Message-based agent abstraction using F# MailboxProcessor
  - Asynchronous, concurrent API execution model
  - Specific low level agent implementations
Informedica.Logging.Lib: Library with advanced printing capabilities to enable human-readable logging for analysis.
- Capabilities:
  - Human-readable logging and structured output for analysis
  - Advanced printing and formatting capabilities
  - Agent-based logging service
Informedica.NLP.Lib: Library using NLP to extract structured rules from free text.
- Capabilities:
  - Natural language processing for rule extraction
  - Conversion of free text to structured typed records
Informedica.OTS.Lib: Library to retrieve and send rules sets to the OTS server for storage and version control. Can also export and import rules sets as spreadsheets.
- Capabilities:
  - Integration with OTS server for product and rule set storage and version control
  - Rule set import/export to spreadsheet formats
  - Can log import and export
  - Can run as an agent based microservice
Informedica.GenUnits.Lib: Domain library handling complex value unit combinations and calculation.
- Capabilities:
  - Complex value-unit combinations and dimensional analysis
  - Unit conversion and validation
  - Arithmetic operations on values with units
Informedica.ZIndex.Lib: Performs first parsing of products and rules from the ZIndex registry. Products can be used by GenFORM.
- Capabilities:
  - Parsing of pharmaceutical products from ZIndex registry
  - Initial rule extraction from ZIndex data
  - Product catalog and formulary management
Informedica.ZForm.Lib: Additional processing of rules to more generic constructs. These rules can be used by GenFORM to check specific dose rules.
- Capabilities:
  - Advanced rule processing and normalization
  - Conversion of ZIndex rules to generic constructs
  - Can store and retrieve products and rules in OTS
  - Can log extraction messages
  - Can run as an agent microservice
  - Can be exposed via MCP host
Informedica.NKF.Lib: Library used to parse structured content from the Kinderformularium containing pediatric dosing rules.
- Capabilities:
  - Parsing of pediatric dosing guidelines from Kinderformularium
  - Structured pediatric dosing rules
  - Can log extraction messages
  - Can run as an agent based microservice
Informedica.FTK.Lib: Library used to parse structured content from the Farmacotherapeutisch Kompas containing pediatric dosing rules.
- Capabilities:
  - Parsing of adult dosing guidelines from Farmacotherapeutisch Kompas
  - Structured adult dosing rules
  - Can log extraction messages
  - Can run as an agent based microservice
Informedica.GenFORM.Lib: Handles all rule sets and combines those with products creating specific patient context prescription rules.
- Capabilities:
  - Unified rule set management across all sources
  - Patient-context-specific prescription rule generation
  - Product-rule combination and validation
  - Can store and retrieve products and rules in OTS
  - Can log all rule retrieval messages
  - Can run as an agent based microservice
  - Can be accessed as a MCP service
Informedica.MCP.Lib: Library enabling a MCP implementation and using LLMs.
- Capabilities:
  - Model Context Protocol (MCP) framework implementation in F#
  - LLM-powered extraction of structured typed records from free text
  - Agent-based MCP service execution
  - Can host ZForm, GenFORM, GenORDER

Appendix C.1. Dose Rule Model Figure

Addendum C.2. Dose Rule Model Table

Object	Variable	Type	Unit	Key	Description
Source	Name	text		yes	The source of the dose rule
Source	Text	text		yes	The source dose description
Generic	Name	text		yes	The generic name
Generic	Form	text		yes	Pharmaceutical form to narrow down the dose rule
Generic	Brand	text		yes	A brand to narrow down the dose rule
Generic	GPKs	text list			A list of GPKs to narrow down the dose rule
Indication	Indication	text		yes	The indication (label) for the dose rule
Route	Route	text		yes	The route
Setting	Location	text			Hospital/institute/organization
Setting	Department	text		yes	The department
Patient	Gender	male / female		yes	The gender
Patient	MinAge	int	day	yes	The minimum age
Patient	MaxAge	int	day	yes	The maximum age
Patient	MinWeight	int	gram	yes	The minimum weight (in gram)
Patient	MaxWeight	int	gram	yes	The maximum weight
Patient	MinBSA	float	m2	yes	The minimum bsa
Patient	MaxBSA	float	m2	yes	The maximum bsa
Patient	MinGestAge	int	day	yes	The minimum gestational age
Patient	MaxGestAge	int	day	yes	The maximum gestational age
Patient	MinPMAge	int	day	yes	The minimum post-menstrual age
Patient	MaxPMAge	int	day	yes	The maximum post-menstrual age
DoseType	DoseType	once / onceTimed / discontinuous / timed / continuous		yes	The dose type of the dose rule
DoseType	DoseText	text			A label for a dose type
Schedule	Freqs	int list	count_unit / freq_unit		The possible frequencies
Schedule	FreqUnit	text			The freq unit
Schedule	MinTime	float	time_unit		The minimum time for infusion of a dose
Schedule	MaxTime	float	time_unit		The maximum time for infusion of a dose
Schedule	TimeUnit	text			The time unit to measure the infusion
Schedule	MinInt	float	int_unit		The minimum interval between two doses
Schedule	MaxInt	float	int_unit		The maximum interval between two doses
Schedule	IntUnit	text			The interval unit
Schedule	MinDur	float	dur_unit		The minimum duration of the dose rule
Schedule	MaxDur	float	dur_unit		The maximum duration of the dose rule
Schedule	DurUnit	text			The duration time unit
Component	Component	text			The component the substance belongs to
Substance	Substance	text			The substance used for the below fields
DoseLimit	DoseUnit	text			The dose unit
DoseLimit	AdjustUnit	kg / m2			The adjust unit
DoseLimit	RateUnit	text			The rate unit
DoseLimit	MinQty	float	dose_unit		The minimum dose quantity
DoseLimit	MaxQty	float	dose_unit		The maximum dose quantity
DoseLimit	MinQtyAdj	float	dose_unit / adjust_unit		The minimum adjusted dose quantity
DoseLimit	MaxQtyAdj	float	dose_unit / adjust_unit		The maximum patient-adjusted dose quantity
DoseLimit	MinPerTime	float	dose_unit / freq_unit		The minimum dose quantity per time
DoseLimit	MaxPerTime	float	dose_unit / freq_unit		The maximum dose quantity per time
DoseLimit	MinPerTimeAdj	float	dose_unit / adjust_unit / freq_unit		The minimum patient-adjusted dose quantity per time
DoseLimit	MaxPerTimeAdj	float	dose_unit / adjust_unit / freq_unit		The maximum dose adjusted quantity per time
DoseLimit	MinRate	float	dose_unit / rate_unit		The minimum dose rate
DoseLimit	MaxRate	float	dose_unit / rate_unit		The maximum dose rate
DoseLimit	MinRateAdj	float	dose_unit / adjust_unit / rate_unit		The minimum patient-adjusted dose rate
DoseLimit	MaxRateAdj	float	dose_unit / adjust_unit / rate_unit		The maximum patient-adjusted dose rate

Addendum C.1. Reconstitution and Solution Rule Model Figure

Addendum C.2. Reconstitution Rule Model Table

Object	Property	Type	Unit	Key	Description
Generic	GPK	text		yes	The unique Generic Product Identifier
Generic	Generic	text			The generic medication name
Generic	Form	text			The pharmaceutical form of the generic medication
Route	Route	text		yes	The route
Setting	Location	text		yes	Hospital / institute / organization
Setting	Department	text		yes	The department
Solution	DiluentVol	float	mL		The volume of the diluent
Solution	ExpansionVol	float	mL		The expansion volume
Solution	Diluents	text list			The possible diluents that can be used

Addendum C.3. Solution Rule Model Table

Object	Property	Type	Unit	Key	Description
Generic	Generic	text		yes	The generic name
Generic	Form	text		yes	The pharmaceutical form name of the generic medication
Route	Route	text		yes	The route
Indication	Indication	text		yes	The corresponding matching dose rule indication
DoseType	DoseType	once / onceTimed / discontinuous / timed / continuous		yes	The dosetype
Administration Access Device	CVL	boolean		yes	Central Venous Line
Administration Access Device	PVL	boolean		yes	Peripheral Venous Line
Setting	Location	text		yes	Hospital / institute / organization
Setting	Department	text		yes	The department
Patient	MinAge	int	day	yes	The minimum age
Patient	MaxAge	int	day	yes	The maximum age
Patient	MinWeight	int	gram	yes	The minimum weight
Patient	MaxWeight	int	gram	yes	The maximum weight
SolutionRule	MinDose	float	unit	yes	The minimum dose
SolutionRule	MaxDose	float	unit	yes	The maximum dose
SolutionRule	Solutions	text list			The possible solutions that can be used
SolutionRule	Volumes	float list	mL		The possible volume quantities that can be used
SolutionRule	MinVol	float	mL		The minimum volume
SolutionRule	MaxVol	float	mL		The maximum volume
SolutionRule	MinVolAdj	float	mL / kg		The minimum allowed solution volume
SolutionRule	MaxVolAdj	float	mL / kg		The maximum allowed solution volume
SolutionRule	MinDrip	float	mL / hour		The minimum allowed infusion rate
SolutionRule	MaxDrip	float	mL / hour		The maximum allowed infusion rate
SolutionRule	MinPerc	float	perc		The minimum percentage of the solution to use for the DoseQuantity
SolutionRule	MaxPerc	float	perc		The maximum percentage of the solution to use for the DoseQuantity
SolutionLimit	Substance	text			The substance used for the below fields
SolutionLimit	SubstUnit	text			The unit to measure the substance
SolutionLimit	Quantities	float list	subst_unit		The substance quantities that can be used
SolutionLimit	MinQty	float	subst_unit		The minimum substance quantity
SolutionLimit	MaxQty	float	subst_unit		The maximum substance quantity
SolutionLimit	MinConc	float	subst_unit / mL		The minimum substance concentration
SolutionLimit	MaxConc	float	subst_unit / mL		The maximum substance concentration

Addendum D.1. Renal Rule Model Figure

Addendum D.2. Renal Rule Model Table

Object	Variable	Type	Unit	Key	Description
Generic	Generic	text		yes	The generic name
Route	Route	text		yes	The route
Indication	Indication	text		yes	The corresponding matching dose rule indication
Source	Source	text		yes	The source of the renal rule
Patient	MinAge	int	day	yes	The minimum age
Patient	MaxAge	int	day	yes	The maximum age
Renal	ContDial	boolean		yes	If continuous dialysis
Renal	IntDial	boolean		yes	If discontinuous dialysis
Renal	PerDial	boolean		yes	If peritoneal dialysis
Renal	MinGFR	float	mL / min / 1.73 m2	yes	The minimum standardized GFR
Renal	MaxGFR	float	mL / min / 1.73 m2	yes	The maximum standardized GFR
DoseType	DoseType	once / onceTimed / discontinuous / timed / continuous		yes	Dose type
DoseType	DoseText	text		yes	The dose type description
Schedule	Freqs	int list	count / freq_unit	yes	The possible frequencies
Schedule	MinInt	float	int_unit		The minimum interval duration
Schedule	MaxInt	float	int_unit		The maximum interval duration
Schedule	IntUnit	text			The interval time unit
Substance	Substance	text			The matching substance for the DoseLimit
Adjustment	DoseRed	rel / abs			Whether the dose limit is relative or absolute
DoseLimit	DoseUnit	text			The dose substance dose unit
DoseLimit	AdjustUnit	text			The adjust unit (kg or m2)
Schedule	FreqUnit	text			The frequency time unit
Schedule	RateUnit	text			The rate time unit
DoseLimit	MinQty	float	count /dose_unit		The relative or absolute minimum dose quantity (renal adjustment)
DoseLimit	MaxQty	float	count /dose_unit		The relative or absolute maximum dose quantity (renal adjustment)
DoseLimit	NormQtyAdj	float	count /dose_unit / adjust_unit		The relative or absolute norm dose patient-adjusted quantity (renal adjustment)
DoseLimit	MinQtyAdj	float	count /dose_unit / adjust_unit		The relative or absolute minimum dose patient-adjusted quantity (renal adjustment)
DoseLimit	MaxQtyAdj	float	count /dose_unit / adjust_unit		The relative or absolute maximum dose patient-adjusted quantity (renal adjustment)
DoseLimit	MinPerTime	float	count /dose_unit / freq_unit		The relative or absolute minimum dose per time (renal adjustment)
DoseLimit	MaxPerTime	float	count /dose_unit / freq_unit		The relative or absolute maximum dose per time (renal adjustment)
DoseLimit	NormPerTimeAdj	float	count /dose_unit / adjust_unit / freq_unit		The relative or absolute norm dose patient-adjusted per time (renal adjustment)
DoseLimit	MinPerTimeAdj	float	count /dose_unit / adjust_unit / freq_unit		The relative or absolute minimum dose patient-adjusted per time (renal adjustment)
DoseLimit	MaxPerTimeAdj	float	count /dose_unit / adjust_unit / freq_unit		The relative or absolute maximum dose patient-adjusted per time (renal adjustment)
DoseLimit	MinRate	float	count /dose_unit / rate_unit		The relative or absolute minimum dose rate (renal adjustment)
DoseLimit	MaxRate	float	count /dose_unit / rate_unit		The relative or absolute maximum dose rate (renal adjustment)
DoseLimit	MinRateAdj	float	count /dose_unit / adjust_unit / rate_unit		The relative or absolute minimum patient-adjusted dose rate (renal adjustment)
DoseLimit	MaxRateAdj	float	count /dose_unit / adjust_unit / rate_unit		The relative or absolute minimum patient-adjusted dose rate (renal adjustment)

Addendum E.1. Product Component Model Figure

Addendum E.2. Product Component Model Table

Object	Prop	Type	Unit	Key	Description
GenPRES Product	Name	text		yes	The name of the GenPRES product.
GenPRES Product	Form	text		yes	Shared pharmaceutical form for all included generic products.
GenPRES Product	Routes	text list		yes	Routes of administration associated with the GenPRES product.
GenPRES Product	PharmacologicalGroups	text list			Pharmacological groups applied to this product.
GenPRES Product	Unit	text		yes	Dose unit used at the GenPRES level (e.g., mg, mmol, IU).
GenPRES Product	Synonyms	text list			Synonyms for searching and matching.
GenPRES Product	GenericProducts	Generic Product list			Generic products belonging to this GenPRES product.
Generic Product	Id (GPK)	int		yes	Generic product identifier (GPK).
Generic Product	Name	text		yes	Full generic product name.
Generic Product	Label	text		yes	Display label for the generic product.
Generic Product	ATC	text			ATC-5 code for classification.
Generic Product	ATCName	text			ATC-5 description.
Generic Product	Form	text		yes	Pharmaceutical form.
Generic Product	Routes	text list		yes	Routes of administration.
Generic Product	Substances	ProductSubstance list		yes	Full substance composition of the generic product.
Generic Product	PrescriptionProducts	Prescription Product list			Prescription products belonging to this generic product.
Product Substance	SubstanceId	int			Identifier of the substance.
Product Substance	SortOrder	int			Ordering index for display and naming.
Product Substance	SubstanceName	text		yes	Name of the active or additional substance.
Product Substance	SubstanceQuantity	float	substance_unit	yes	Quantity of the substance.
Product Substance	SubstanceUnit	text		yes	Unit of the substance quantity.
Product Substance	GenericId	int			Identifier of the underlying generic substance.
Product Substance	GenericName	text			Name of the generic (salt) substance.
Product Substance	GenericQuantity	float	generic_unit		Quantity of the generic substance.
Product Substance	GenericUnit	text			Unit of measured generic substance.
Product Substance	FormUnit	text			Form-dependent unit (e.g., mg/mL).
Product Substance	IsAdditional	boolean			Whether substance is additional (not active).
Prescription Product	Id (PRK)	int		yes	Prescription product identifier (PRK).
Prescription Product	Name	text		yes	Full prescription product name.
Prescription Product	Label	text		yes	Display label for prescription product.
Prescription Product	Quantity	float	form_unit	yes	Pharmaceutical form quantity.
Prescription Product	Unit	text		yes	Unit corresponding to Quantity.
Prescription Product	Container	text			Container description.
Prescription Product	TradeProducts	Trade Product list			Trade products included under this prescription product.
Trade Product	Id (HPK)	int		yes	Trade product identifier (HPK).
Trade Product	Name	text		yes	Full trade product name.
Trade Product	Label	text			Display label.
Trade Product	Brand	text		yes	Brand/manufacturer’s product name.
Trade Product	Company	text			Company/marketing authorization holder.
Trade Product	Denominator	int			Strength denominator used for concentration.
Trade Product	UnitWeight	float	unit		Strength or unit weight.
Trade Product	Route	text list			Routes of administration.
Trade Product	Substances	Product Substance list			Substance composition at trade level.
Trade Product	ConsumerProducts	Consumer Product list			Consumer-level package variants.
Consumer Product	Id (ZInr)	int		yes	Consumer product identifier.
Consumer Product	Name	text			Consumer product name.
Consumer Product	Label	text			Display label.
Consumer Product	Quantity	float	container_unit	yes	Pack quantity for consumer sale.
Consumer Product	Container	text		yes	Container description.
Product Component	GPK	int			Generic product identifier.
Product Component	ATC	text			ATC classification code.
Product Component	MainGroup	text			Main pharmacological group.
Product Component	SubGroup	text			Subgroup classification.
Product Component	Generic	text			Generic name.
Product Component	UseGenericName	boolean			Whether generic name should be used for display.
Product Component	UseForm	boolean			Whether the pharmaceutical form should be included in naming.
Product Component	UseBrand	boolean			Whether brand name should be used.
Product Component	TallMan	text			Tall-Man lettering for LASA safety.
Product Component	Synonyms	text list			Search synonyms.
Product Component	Product	text			Product name generated for user-facing display.
Product Component	Label	text			Label used in UI/selection.
Product Component	Form	text			Pharmaceutical form.
Product Component	Routes	text list			Routes of administration.
Product Component	FormQuantities	float list	form_unit		List of form quantities (e.g., 5 mg, 10 mg).
Product Component	FormUnit	text			Unit corresponding to form quantities.
Product Component	RequiresReconstitution	boolean			Whether the product requires reconstitution before use.
Product Component	Reconstitution	text			Description or parameters for reconstitution.
Product Component	Divisible	int			Divisibility of the dosage form.
Product Component	Substances	Substance Item list			Substance items associated with this component.

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