diff --git a/.changelog/44500.txt b/.changelog/44500.txt
new file mode 100644
index 000000000000..6a9032562630
--- /dev/null
+++ b/.changelog/44500.txt
@@ -0,0 +1,3 @@
+```release-note:bug
+resource/aws_lb_target_group: Suppress diff for `stickiness`, `target_failover`, and `target_group_health` attributes when `target_type` is `lambda`
+```
\ No newline at end of file
diff --git a/internal/service/elbv2/target_group.go b/internal/service/elbv2/target_group.go
index d5b051f0e2d5..ba77fb7546f8 100644
--- a/internal/service/elbv2/target_group.go
+++ b/internal/service/elbv2/target_group.go
@@ -258,10 +258,11 @@ func resourceTargetGroup() *schema.Resource {
 				),
 			},
 			"stickiness": {
-				Type:     schema.TypeList,
-				Optional: true,
-				Computed: true,
-				MaxItems: 1,
+				Type:             schema.TypeList,
+				Optional:         true,
+				Computed:         true,
+				MaxItems:         1,
+				DiffSuppressFunc: suppressIfTargetType(awstypes.TargetTypeEnumLambda),
 				Elem: &schema.Resource{
 					Schema: map[string]*schema.Schema{
 						"cookie_duration": {
@@ -297,9 +298,10 @@ func resourceTargetGroup() *schema.Resource {
 			names.AttrTags:    tftags.TagsSchema(),
 			names.AttrTagsAll: tftags.TagsSchemaComputed(),
 			"target_failover": {
-				Type:     schema.TypeList,
-				Optional: true,
-				Computed: true,
+				Type:             schema.TypeList,
+				Optional:         true,
+				Computed:         true,
+				DiffSuppressFunc: suppressIfTargetType(awstypes.TargetTypeEnumLambda),
 				Elem: &schema.Resource{
 					Schema: map[string]*schema.Schema{
 						"on_deregistration": {
@@ -316,10 +318,11 @@ func resourceTargetGroup() *schema.Resource {
 				},
 			},
 			"target_group_health": {
-				Type:     schema.TypeList,
-				Optional: true,
-				Computed: true,
-				MaxItems: 1,
+				Type:             schema.TypeList,
+				Optional:         true,
+				Computed:         true,
+				MaxItems:         1,
+				DiffSuppressFunc: suppressIfTargetType(awstypes.TargetTypeEnumLambda),
 				Elem: &schema.Resource{
 					Schema: map[string]*schema.Schema{
 						"dns_failover": {