-Lossy compression of raw nanopore signal data can be a great way to save disk space without significantly impacting basecalling and modification calling accuracy. This makes it particularly suitable for archiving, especially if you are running short of available disk space. For instance, we were running out of disk space in our in-house storage systems at Garvan Institute long read sequencing service. So we lossy compressed all our historical datasets, the original BLOW5 files that consumed X TB, reduced to Y after compressed to BLOW5s with lossy compression.
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