diff --git a/.gitignore b/.gitignore
index cb9d10c0d..f550832ad 100644
--- a/.gitignore
+++ b/.gitignore
@@ -3,6 +3,7 @@ __pycache__
 node_modules
 .cache
 .DS_STORE
+deno.lock
 
 # Do not track build artifacts/generated files
 /dist
diff --git a/package.json b/package.json
index 8fd8857e6..3bea70483 100644
--- a/package.json
+++ b/package.json
@@ -82,13 +82,6 @@
     "README.md",
     "LICENSE"
   ],
-  "browser": {
-    "fs": false,
-    "path": false,
-    "url": false,
-    "sharp": false,
-    "onnxruntime-node": false
-  },
   "publishConfig": {
     "access": "public"
   },
diff --git a/src/env.js b/src/env.js
index 5e81af486..fd3924213 100644
--- a/src/env.js
+++ b/src/env.js
@@ -22,9 +22,9 @@
  * @module env
  */
 
-import fs from 'fs';
-import path from 'path';
-import url from 'url';
+import fs from 'node:fs';
+import path from 'node:path';
+import url from 'node:url';
 
 const VERSION = '3.5.2';
 
@@ -40,6 +40,10 @@ const IS_NODE_ENV = IS_PROCESS_AVAILABLE && process?.release?.name === 'node';
 const IS_FS_AVAILABLE = !isEmpty(fs);
 const IS_PATH_AVAILABLE = !isEmpty(path);
 
+// Runtime detection
+const IS_DENO_RUNTIME = typeof globalThis.Deno !== 'undefined';
+const IS_BUN_RUNTIME = typeof globalThis.Bun !== 'undefined';
+
 /**
  * A read-only object containing information about the APIs available in the current environment.
  */
@@ -62,7 +66,7 @@ export const apis = Object.freeze({
     /** Whether the Node.js process API is available */
     IS_PROCESS_AVAILABLE,
 
-    /** Whether we are running in a Node.js environment */
+    /** Whether we are running in a Node.js-like environment (node, deno, bun) */
     IS_NODE_ENV,
 
     /** Whether the filesystem API is available */
@@ -143,7 +147,7 @@ export const env = {
     useFS: IS_FS_AVAILABLE,
 
     /////////////////// Cache settings ///////////////////
-    useBrowserCache: IS_WEB_CACHE_AVAILABLE,
+    useBrowserCache: IS_WEB_CACHE_AVAILABLE && !IS_DENO_RUNTIME,
 
     useFSCache: IS_FS_AVAILABLE,
     cacheDir: DEFAULT_CACHE_DIR,
diff --git a/src/utils/audio.js b/src/utils/audio.js
index 7d915c24d..23af5dc8a 100644
--- a/src/utils/audio.js
+++ b/src/utils/audio.js
@@ -15,9 +15,8 @@ import {
     calculateReflectOffset, saveBlob,
 } from './core.js';
 import { apis } from '../env.js';
-import fs from 'fs';
 import { Tensor, matmul } from './tensor.js';
-
+import fs from 'node:fs';
 
 /**
  * Helper function to read audio from a path/URL.
diff --git a/src/utils/hub.js b/src/utils/hub.js
index 5b3bb7520..fa700a898 100755
--- a/src/utils/hub.js
+++ b/src/utils/hub.js
@@ -5,8 +5,8 @@
  * @module utils/hub
  */
 
-import fs from 'fs';
-import path from 'path';
+import fs from 'node:fs';
+import path from 'node:path';
 
 import { apis, env } from '../env.js';
 import { dispatchCallback } from './core.js';
diff --git a/tests/test_utils.js b/tests/test_utils.js
index c42c5f201..3311b9aeb 100644
--- a/tests/test_utils.js
+++ b/tests/test_utils.js
@@ -1,6 +1,6 @@
-import fs from "fs";
-import path from "path";
-import { fileURLToPath } from "url";
+import fs from "node:fs";
+import path from "node:path";
+import { fileURLToPath } from "node:url";
 
 export async function loadAudio(url) {
   // NOTE: Since the Web Audio API is not available in Node.js, we will need to use the `wavefile` library to obtain the raw audio data.
diff --git a/tests/utils/hub.test.js b/tests/utils/hub.test.js
index f819efc35..00fd5f196 100644
--- a/tests/utils/hub.test.js
+++ b/tests/utils/hub.test.js
@@ -1,7 +1,7 @@
 import { AutoModel, PreTrainedModel } from "../../src/models.js";
 
 import { MAX_TEST_EXECUTION_TIME, DEFAULT_MODEL_OPTIONS } from "../init.js";
-import fs from "fs";
+import fs from "node:fs";
 
 // TODO: Set cache folder to a temp directory
 
diff --git a/webpack.config.js b/webpack.config.js
index 09611f1e4..53b5ccd9d 100644
--- a/webpack.config.js
+++ b/webpack.config.js
@@ -1,10 +1,35 @@
+import { fileURLToPath } from "node:url";
+import path from "node:path";
+import fs from "node:fs";
+import webpack from "webpack";
 import TerserPlugin from "terser-webpack-plugin";
-import { fileURLToPath } from "url";
-import path from "path";
-import fs from "fs";
 
 const __dirname = path.dirname(fileURLToPath(import.meta.url));
 
+/**
+ * Plugin to strip the "node:" prefix from module requests.
+ * 
+ * This is necessary to ensure both web and node builds work correctly,
+ * otherwise we would get an error like:
+ * ```
+ * Module build failed: UnhandledSchemeError: Reading from "node:path" is not handled by plugins (Unhandled scheme).
+ * Webpack supports "data:" and "file:" URIs by default.
+ * You may need an additional plugin to handle "node:" URIs.
+ * ```
+ * 
+ * NOTE: We then do not need to use the `node:` prefix in the resolve.alias configuration.
+ */
+class StripNodePrefixPlugin extends webpack.NormalModuleReplacementPlugin {
+  constructor() {
+    super(
+      /^node:(.+)$/,
+      resource => {
+        resource.request = resource.request.replace(/^node:/, '');
+      }
+    );
+  }
+}
+
 /**
  * Plugin to post-process build files. Required to solve certain issues with ESM module output.
  * See https://github.com/webpack/webpack/issues/17121 for more information.
@@ -55,7 +80,6 @@ function buildConfig({
   plugins = [],
 } = {}) {
   const outputModule = type === "module";
-
   const alias = Object.fromEntries(
     ignoreModules.map((module) => [module, false]),
   );
@@ -137,13 +161,15 @@ const NODE_EXTERNAL_MODULES = [
   "onnxruntime-common",
   "onnxruntime-node",
   "sharp",
-  "fs",
-  "path",
-  "url",
+  "node:fs",
+  "node:path",
+  "node:url",
 ];
 
-// Do not bundle onnxruntime-node when packaging for the web.
-const WEB_IGNORE_MODULES = ["onnxruntime-node"];
+// Do not bundle node-only packages when bundling for the web.
+// NOTE: We can exclude the "node:" prefix for built-in modules here,
+// since we apply the `StripNodePrefixPlugin` to strip it.
+const WEB_IGNORE_MODULES = ["onnxruntime-node", "sharp", "fs", "path", "url"];
 
 // Do not bundle the following modules with webpack (mark as external)
 const WEB_EXTERNAL_MODULES = [
@@ -157,12 +183,19 @@ const WEB_BUILD = buildConfig({
   type: "module",
   ignoreModules: WEB_IGNORE_MODULES,
   externalModules: WEB_EXTERNAL_MODULES,
+  plugins: [
+    new StripNodePrefixPlugin()
+  ]
 });
 
 // Web-only build, bundled with onnxruntime-web
 const BUNDLE_BUILD = buildConfig({
   type: "module",
-  plugins: [new PostBuildPlugin()],
+  ignoreModules: WEB_IGNORE_MODULES,
+  plugins: [
+    new StripNodePrefixPlugin(),
+    new PostBuildPlugin(),
+  ],
 });
 
 // Node-compatible builds