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What happened?
The following code (mostly taken from the example you have documented aside from me adding in the grading_groups) works fine.
library(dplyr)
data <- teal_data()
data <- within(data, {
  ADSL <- tmc_ex_adsl
  .lbls_adae <- col_labels(tmc_ex_adae)
  ADAE <- tmc_ex_adae %>%
    mutate_if(is.character, as.factor) #' be certain of having factors
  col_labels(ADAE) <- .lbls_adae
})
join_keys(data) <- default_cdisc_join_keys[names(data)]
ADSL <- data[["ADSL"]]
ADAE <- data[["ADAE"]]
app <- init(
  data = data,
  modules = modules(
    tm_t_events_by_grade(
      label = "Adverse Events by Grade Table",
      dataname = "ADAE",
      arm_var = choices_selected(c("ARM", "ARMCD"), "ARM"),
      llt = choices_selected(
        choices = variable_choices(ADAE, c("AETERM", "AEDECOD")),
        selected = c("AEDECOD")
      ),
      hlt = choices_selected(
        choices = variable_choices(ADAE, c("AEBODSYS", "AESOC")),
        selected = "AEBODSYS"
      ),
      grade = choices_selected(
        choices = variable_choices(ADAE, c("AETOXGR", "AESEV")),
        selected = "AETOXGR"
      ),
      grading_groups = list(`Any Grade (%)` = c("1", "2", "3", "4", "5"), 
                            `Grade 1 (%)` = c("1"), `Grade 2 (%)` = c("2"), `Grade 3 (%)` = c("3"), `Grade 4 (%)` = c("4"), `Grade 5 (%)` = c("5"), `Grade 3-5 (%)` = c("3", "4", "5"))
    )
  )
)
if (interactive()) {
  shinyApp(app$ui, app$server)
}If you run the above code and then check the "Display grade groupings in nested columns" box, we see the desired output.
However, when i switch to use Grade >= 3 instead of Grade 3-5 and then check the "Display grade groupings in nested columns" box, the app does not run. I think it does not like the >= in some cases?
Non-working code:
library(dplyr)
data <- teal_data()
data <- within(data, {
  ADSL <- tmc_ex_adsl
  .lbls_adae <- col_labels(tmc_ex_adae)
  ADAE <- tmc_ex_adae %>%
    mutate_if(is.character, as.factor) #' be certain of having factors
  col_labels(ADAE) <- .lbls_adae
})
join_keys(data) <- default_cdisc_join_keys[names(data)]
ADSL <- data[["ADSL"]]
ADAE <- data[["ADAE"]]
app <- init(
  data = data,
  modules = modules(
    tm_t_events_by_grade(
      label = "Adverse Events by Grade Table",
      dataname = "ADAE",
      arm_var = choices_selected(c("ARM", "ARMCD"), "ARM"),
      llt = choices_selected(
        choices = variable_choices(ADAE, c("AETERM", "AEDECOD")),
        selected = c("AEDECOD")
      ),
      hlt = choices_selected(
        choices = variable_choices(ADAE, c("AEBODSYS", "AESOC")),
        selected = "AEBODSYS"
      ),
      grade = choices_selected(
        choices = variable_choices(ADAE, c("AETOXGR", "AESEV")),
        selected = "AETOXGR"
      ),
      grading_groups = list(`Any Grade (%)` = c("1", "2", "3", "4", "5"), 
                            `Grade 1 (%)` = c("1"), `Grade 2 (%)` = c("2"), `Grade 3 (%)` = c("3"), `Grade 4 (%)` = c("4"), `Grade 5 (%)` = c("5"), `Grade >=3 (%)` = c("3", "4", "5"))
    )
  )
)
if (interactive()) {
  shinyApp(app$ui, app$server)
}sessionInfo()
R version 4.4.1 (2024-06-14)
Platform: x86_64-pc-linux-gnu
Running under: Rocky Linux 8.10 (Green Obsidian)
Matrix products: default
BLAS/LAPACK: /usr/lib64/libopenblasp-r0.3.15.so;  LAPACK version 3.9.0
locale:
 [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C               LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8     LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8    LC_PAPER=en_US.UTF-8      
 [8] LC_NAME=C                  LC_ADDRESS=C               LC_TELEPHONE=C             LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
time zone: Etc/UTC
tzcode source: system (glibc)
attached base packages:
[1] stats     graphics  grDevices datasets  utils     methods   base     
other attached packages:
 [1] forcats_1.0.0                   teal.widgets_0.4.3              DT_0.33                         openxlsx_4.2.8                  fs_1.6.5                       
 [6] stringr_1.5.1                   tidyr_1.3.1                     haven_2.5.4                     dplyr_1.1.4                     tibble_3.2.1                   
[11] teal.reporter_0.4.0             httr2_1.1.0                     junco_0.0.1                     tidytlg_0.1.5                   teal.modules.clinical.jnj_0.1.3
[16] teal.modules.general_0.4.0      ggmosaic_0.3.3                  ggplot2_3.5.1                   teal.modules.clinical_0.10.0    tern_0.9.7                     
[21] rtables_0.6.11                  magrittr_2.0.3                  formatters_0.5.10               teal.transform_0.6.0            teal_0.16.0                    
[26] teal.slice_0.6.0                teal.data_0.7.0                 teal.code_0.6.1                 shiny_1.10.0                   
loaded via a namespace (and not attached):
 [1] rstudioapi_0.17.1     jsonlite_1.9.0        nestcolor_0.1.3       TH.data_1.1-3         estimability_1.5.1    farver_2.1.2          rmarkdown_2.29        geepack_1.3.12       
 [9] vctrs_0.6.5           memoise_2.0.1         askpass_1.2.1         htmltools_0.5.8.1     broom_1.0.7           cellranger_1.1.0      gridGraphics_0.5-1    sass_0.4.9           
[17] huxtable_5.5.7        bslib_0.9.0           htmlwidgets_1.6.4     fontawesome_0.5.3     sandwich_3.1-1        emmeans_1.10.7        plotly_4.10.4         zoo_1.8-13           
[25] cachem_1.1.0          mime_0.12             lifecycle_1.0.4       pkgconfig_2.0.3       Matrix_1.7-1          R6_2.6.1              fastmap_1.2.0         rbibutils_2.3        
[33] digest_0.6.37         colorspace_2.1-1      patchwork_1.3.0       shinycssloaders_1.1.0 crosstalk_1.2.1       httr_1.4.7            compiler_4.4.1        withr_3.0.2          
[41] backports_1.5.0       logger_0.4.0          MASS_7.3-61           rappdirs_0.3.3        tools_4.4.1           zip_2.3.2             httpuv_1.6.15         shinyvalidate_0.1.3  
[49] glue_1.8.0            nlme_3.1-166          promises_1.3.2        grid_4.4.1            checkmate_2.3.2       generics_0.1.3        gtable_0.3.6          tzdb_0.4.0           
[57] data.table_1.17.0     hms_1.1.3             ggrepel_0.9.6         pillar_1.10.1         yulab.utils_0.2.0     later_1.4.1           splines_4.4.1         tern.gee_0.1.5       
[65] lattice_0.22-6        renv_1.0.7            survival_3.7-0        tidyselect_1.2.1      knitr_1.49            teal.logger_0.3.2     xfun_0.51             stringi_1.8.4        
[73] lazyeval_0.2.2        yaml_2.3.10           shinyWidgets_0.9.0    evaluate_1.0.3        codetools_0.2-20      ggplotify_0.1.2       cli_3.6.4             xtable_1.8-4         
[81] Rdpack_2.6.2          munsell_0.5.1         jquerylib_0.1.4       Rcpp_1.0.14           readxl_1.4.3          png_0.1-8             readr_2.1.5           assertthat_0.2.1     
[89] viridisLite_0.4.2     mvtnorm_1.3-3         scales_1.3.0          purrr_1.0.4           crayon_1.5.3          rlang_1.1.5           cowplot_1.1.3         multcomp_1.4-28      
[97] shinyjs_2.1.0Relevant log output
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bugSomething isn't workingSomething isn't working