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examples/data_release/2025_data_release_autism_noel.md

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# 2025 - Autism
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This is the dataset associated with the publication __A common computational and neural anomaly across mouse models of autism__
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Nature Neuroscience | Volume 28 | July 2025 | 1519–1532 1519 nature neuroscience
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https://doi.org/10.1038/s41593-025-01965-8
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This is the dataset associated with the publication [A common computational and neural anomaly across mouse models of autism](https://www.nature.com/articles/s41593-025-01965-8).
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Electrophysiology, behavioral and video data were collected in mice performing the [IBL task](https://pubmed.ncbi.nlm.nih.gov/34011433/).
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Animals were either wildtype, or from one of 3 different autism models:
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- B6.129P2-Fmr1tm1Cgr/J JAX Strain #003025
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- B6.129(Cg)-Cntnap2tm2Pele/J JAX Strain #028635
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- B6.129-Shank3tm2Gfng/J JAX Strain #017688
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- _B6.129P2-Fmr1tm1Cgr/J_ JAX Strain #003025
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- _B6.129(Cg)-Cntnap2tm2Pele/J_ JAX Strain #028635
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- _B6.129-Shank3tm2Gfng/J_ JAX Strain #017688
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The following data repository contains intermediate results and code to reproduce the analysis: https://osf.io/fap2s/ and https://osf.io/fap2s/wiki/home/.
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## Overview of the Data
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We have released data from 198 Neuropixel experimental sessions, with single Neuropixel recordings, referred to as probe insertions. Those were obtained with 62 genetically modified subjects performing the IBL task.
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As output of spike-sorting, there are XXX units; of which XXX are considered to be of good quality. In total, XXX brain regions were recorded in sufficient numbers for comparison with IBL’s analysises [(IBL et al. 2023)](https://doi.org/10.1101/2023.07.04.547681).
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As output of spike-sorting, there are XXX units; of which XXX are considered to be of good quality. In total, XXX brain regions were recorded in sufficient numbers for comparison with IBL’s analyses [(IBL et al. 2023)](https://doi.org/10.1101/2023.07.04.547681).
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| Model | Subject Count | Neuropixel Count |
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|----------|---------------| --- |
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| Wildtype | 15 | 51|
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| Cntnap2 | 17 | 52|
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| shank3 | 15 | 41|
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| fmr1 | 15 | 54|
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| Shank3b | 15 | 41|
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| Fmr1 | 15 | 54|
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## Data structure and download
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The organisation of the data follows the standard IBL data structure.
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| 8e5c51e1-690d-4b50-88c4-37242d5ccb65 | 8d3b57dd-4651-4c5f-a4c3-8de8865fdca3 | CSP026 | 2021-06-10 | 001 | probe00 |
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| fab06f3a-9ff5-405d-957c-6e628c25af3d | 7b3be2f3-e11c-4352-b73f-10e7813ccec9 | CSP026 | 2021-06-11 | 001 | probe00 |
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| 8d6c9ffc-6606-4f11-89bf-cc422ce5022a | 50911ee6-732b-4b07-afe0-8c48a287c803 | NYU-49 | 2021-07-23 | 001 | probe01 |
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