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Widefield data were collected in 5 mice performing the [IBL task](https://pubmed.ncbi.nlm.nih.gov/34011433/).
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Animals were either wildtype, or from the autism models TRE-GCaMP6s-CAMKII; NRXN KO.
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## Overview of the Data
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| Subject | Experimental Sessions | Strain |
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|:--------|----------------------:|--------:|
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| FD_14 | 3 | NRXN WT |
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| FD_21 | 4 | NRXN WT |
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| FD_24 | 4 | NRXN WT |
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| FD_28 | 3 | NRXN KO |
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| FD_36 | 3 | NRXN KO |
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| Total | 17 | - |
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## Data structure and download
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The organisation of the data follows the standard IBL data structure.
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Please see
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*[These instructions](https://int-brain-lab.github.io/iblenv/notebooks_external/data_structure.html) to download an example dataset for one session, and get familiarised with the data structure
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*[These instructions](https://int-brain-lab.github.io/iblenv/notebooks_external/data_download.html) to learn how to use the ONE-api to search and download the released datasets
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*[These instructions](https://int-brain-lab.github.io/iblenv/loading_examples.html) to get familiarised with specific data loading functions
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Note:
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* The tag associated to this release is `2025_Q3_Davatolhagh_et_al_autism`
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## How to cite this dataset
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If you are using this dataset for your research please cite _Davatolhagh, M.F., Couto, J., Melin, M., Oesch, L.T., Findling, C., Morales, P., Hong, I., International Brain Laboratory, Churchland, A.K. Altered Use of Prior Expectations Shapes Behavior and Neural Dynamics in a Mouse Model of Autism_ in preparation.
Copy file name to clipboardExpand all lines: examples/data_release/2025_data_release_autism_noel.md
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## Overview of the Data
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We have released data from 198 Neuropixel experimental sessions, with single Neuropixel recordings, referred to as probe insertions. Those were obtained with 62 genetically modified subjects performing the IBL task.
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As output of spike-sorting, there are XXX units; of which XXX are considered to be of good quality. In total, XXX brain regions were recorded in sufficient numbers for comparison with IBL’s analyses [(IBL et al. 2023)](https://doi.org/10.1101/2023.07.04.547681).
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As output of spike-sorting, there are 71,067 units; of which 12,163 are passing IBL automated quality control.
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| Model | Subject Count | Neuropixel Count |
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|----------|---------------| --- |
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| Wildtype | 15 | 51|
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| Cntnap2 | 17 | 52|
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| Shank3b | 15 | 41|
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| Fmr1 | 15 | 54|
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| Strain | Subject Count | Recording Count | Units Count | Good Units Count |
The organisation of the data follows the standard IBL data structure.
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## How to cite this dataset
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If you are using this dataset for your research please cite:
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- the paper [A common computational and neural anomaly across mouse models of autism](https://doi.org/10.1038/s41593-025-01965-8)
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- if you download the data via ONE (recommended), cite the DOI: 10.6084/m9.figshare.30024880
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- if you download the data via ONE (recommended), cite the DOI: [10.6084/m9.figshare.30024880](https://figshare.com/account/articles/30024880?file=57596791)
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- if you download the data via OSF (not recommended), please use the OSF DOI.
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## Data release notes and changelog
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### 2025-08-29: initial release
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Possible future evolutions
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Possible future evolutions:
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- Spike sorting re-run with iblsorter or newer algorithm to have better yield and better pre-processing
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- Perform the missing alignments with an automatic tool to get
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- Perfom new alignments of the brain region labels with regards to the ephys signatures using an automatic tool
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IBL aims to understand the neural basis of decision-making in the mouse by gathering a whole-brain activity map composed of electrophysiological recordings pooled from multiple laboratories.
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We have systematically recorded from nearly all major brain areas with Neuropixels probes, using a grid system for unbiased sampling and replicating each recording site in at least two laboratories.
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These data have been used to construct a brain-wide map of activity at single-spike cellular resolution during a [decision-making task]((https://elifesciences.org/articles/63711)).
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Please read the associated article [(IBL et al. 2023)](https://doi.org/10.1101/2023.07.04.547681).
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Please read the associated article [(IBL et al. 2025)](https://www.nature.com/articles/s41586-025-09235-0).
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In addition to the map, this data set contains other information gathered during the task: sensory stimuli presented to the mouse;
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mouse decisions and response times; and mouse pose information from video recordings and DeepLabCut analysis.
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Please read our accompanying [technical paper](https://doi.org/10.6084/m9.figshare.21400815) for details on the experiment and data processing pipelines.
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We have released data from 459 Neuropixel experimental sessions, which encompass 699 distinct recordings,
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referred to as probe insertions. Those were obtained with 139 subjects performing the IBL task across 12 different laboratories.
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As output of spike-sorting, there are 621,733 units; of which 75,708 are considered to be of good quality.
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In total, 241 brain regions were recorded in sufficient numbers for inclusion in IBL’s analyses [(IBL et al. 2023)](https://doi.org/10.1101/2023.07.04.547681).
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In total, 241 brain regions were recorded in sufficient numbers for inclusion in IBL’s analyses [(IBL et al. 2025)](https://doi.org/10.1101/2023.07.04.547681).
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